Rentosertib, A generative AI-discovered TNIK inhibitor for idiopathic #pulmonaryfibrosis: a randomized phase 2a trial
Interesting if consistently confirmed effective, seems to have a relatively small rate of GI side effects.
www.nature.com/articles/s41...
Interesting if consistently confirmed effective, seems to have a relatively small rate of GI side effects.
www.nature.com/articles/s41...
June 9, 2025 at 1:57 PM
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The EU-PFF Patient Advocacy Forum #PFForum25 gathered advocates, experts & partners in Frankfurt from 24–27 April to strengthen the patient voice in #PulmonaryFibrosis. Patvocates is proud to have supported the forum which focused on collaboration & advocacy. #PatientAdvocacy #LungHealth #EUPFF
May 2, 2025 at 12:28 PM
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On my deep dive into #metabolichealth I observed that its disruption underpins several chronic degenerative diseases, (MASLD, ASCVD, cancers, dementias)
Reflecting on #pulmonaryfibrosis, an age-associated disease—I wonder: Could a global disturbance in metabolic health be a driving factor behind it?
Reflecting on #pulmonaryfibrosis, an age-associated disease—I wonder: Could a global disturbance in metabolic health be a driving factor behind it?
March 5, 2025 at 10:43 AM
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PULMONARY FIBROSIS (França) presenta nou Split: "Pulmonary Fibrosis / Apopathodiaphulatophobia"#PulmonaryFibrosiss#Goregrindd#Noisegrindd#BrutalDeathMetall#Grindcoree#Maig20255#França�#NouSpliti#Metalll#Metala#MúsicaMetalt#MetalMusicsic
May 20, 2025 at 11:56 AM
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From Birth to Breathless: The Confluence of Early-Life Tobacco Exposure and Genetics in Idiopathic Pulmonary Fibrosis
@atscommunity.bsky.social #PulmonaryFibrosis #Tabacco #TabaccoFree
🔓Open Access
www.atsjournals.org/doi/abs/10.1...
@atscommunity.bsky.social #PulmonaryFibrosis #Tabacco #TabaccoFree
🔓Open Access
www.atsjournals.org/doi/abs/10.1...
June 12, 2025 at 3:00 PM
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Diagnosing #LungFibrosis isn't always straightforward but timely and accurate testing helps.
Combining diagnostic tools and evaluation methods give clinicians a clearer picture, and a clearer picture means better care.
#LFAwarenessMonth.
#PFAwareness #EveryBreathMatters #PulmonaryFibrosis
Combining diagnostic tools and evaluation methods give clinicians a clearer picture, and a clearer picture means better care.
#LFAwarenessMonth.
#PFAwareness #EveryBreathMatters #PulmonaryFibrosis
September 15, 2025 at 7:54 AM
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This study shows that inhibition of S1pr3 ameliorates #Bleomycin-induced pulmonary fibrosis by suppressing #Macrophage #M2Polarization via the #PI3K/Akt-Stat3 pathway, suggesting S1pr3 as a #therapeutic target for #PulmonaryFibrosis. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
#OpenAccess: www.sciencedirect.com/science/arti...
October 25, 2025 at 4:15 PM
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interstitial lung disease have different characteristics between sexes
#pulmonaryfibrosis
www.nature.com/articles/s41...
#pulmonaryfibrosis
www.nature.com/articles/s41...
Sex-specific aspects in a population of patients undergoing evaluation for interstitial lung disease with transbronchial cryobiopsy - Scientific Reports
Scientific Reports - Sex-specific aspects in a population of patients undergoing evaluation for interstitial lung disease with transbronchial cryobiopsy
www.nature.com
April 7, 2025 at 1:49 AM
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📣Our work @jci-insight.bsky.social highlights the key role of #cannabinoid receptor 1 in #AlveolarMacrophages in promoting #PulmonaryFibrosis. We propose that pulmonary delivery of #zevaquanabant as an effective and safer therapeutic approach. Details in🧵👇https://insight.jci.org/articles/view/187967
July 3, 2025 at 6:20 PM
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🫁 #PulmonaryFibrosis doesn’t always present loudly
it affects 15,000 Canadians, often progressing before a clear diagnosis is made.
This September, we emphasize early symptom recognition and equitable access to care.
📊 Source: Canadian Lung Association
it affects 15,000 Canadians, often progressing before a clear diagnosis is made.
This September, we emphasize early symptom recognition and equitable access to care.
📊 Source: Canadian Lung Association
September 8, 2025 at 1:39 PM
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PureTech Health’s Phase IIb data show deupirfenidone (LYT-100) may stabilize lung function in #IPF patients with good tolerability—potentially a new standard of care. PureTech's Camilla Graham talks IPF landscape and drug development. #ERS2025 #PulmonaryFibrosis #ClinicalTrials #Biotech
PureTech’s deupirfenidone: Overcoming the efficacy paradigm in IPF
PureTech’s Camilla Graham talks about the IPF landscape, barriers to antifibrotic use, and the development of deupirfenidone.
druganddeviceworld.com
October 1, 2025 at 9:30 AM
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Andy’s a support group co-ordinator at #ActionforPulmonaryFibrosis following his #lungtransplant, & he talks about his journey with #pulmonaryfibrosis & how he’s made it his life mission to support others alongside his team members who assisted him with this piece.
www.facebook.com/share/p/1Jf3...
www.facebook.com/share/p/1Jf3...
November 20, 2024 at 7:29 AM
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Do ground glass opacities really predict inflammation and favorable response to therapy in ILD?
Think again #pulmonaryfibrosis
thorax.bmj.com/content/earl...
Think again #pulmonaryfibrosis
thorax.bmj.com/content/earl...
Impact of quantitative radiological features of interstitial lung disease on immunomodulatory treatment response in three autoimmune interstitial lung disease cohorts
Background The defining radiological features of autoimmune interstitial lung disease (ILD) are ground glass opacification (GGO) and fibrosis. The associations between these features and physiological...
thorax.bmj.com
April 25, 2025 at 7:00 AM
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Lung #Pericyte #Fibrosis
Tuj1/βIIITub+ Pericyte expands in #Bleomyin-induced mouse #PulmonaryFibrosis
A potential anti-fibrotic #Pericrine CXCL10
Not Collagen-depositing
Tubb3 KO🐭➡️exacerbated fibrosis
#SciArt
Yoh-suke Mukouyama lab bioRxiv 2025
www.biorxiv.org/content/10.1...
Tuj1/βIIITub+ Pericyte expands in #Bleomyin-induced mouse #PulmonaryFibrosis
A potential anti-fibrotic #Pericrine CXCL10
Not Collagen-depositing
Tubb3 KO🐭➡️exacerbated fibrosis
#SciArt
Yoh-suke Mukouyama lab bioRxiv 2025
www.biorxiv.org/content/10.1...
May 6, 2025 at 6:57 PM
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🔬 New pooled Phase III data show Boehringer Ingelheim's nerandomilast may cut death risk in IPF & PPF by up to 59%.
#News #ERS2025 #PulmonaryFibrosis #IPF #PPF #ClinicalTrials #RespiratoryHealth
#News #ERS2025 #PulmonaryFibrosis #IPF #PPF #ClinicalTrials #RespiratoryHealth
ERS 2025: Boehringer shared additional data for lung fibrosis therapy
Pooled Phase III data show nerandomilast may reduce death risk in idiopathic pulmonary fibrosis (IPF) and progressive pulmonary fibrosis (PPF).
druganddeviceworld.com
October 2, 2025 at 11:10 AM
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An @atscommunity.bsky.social podcast on environmental factors contributing to interstitial lung disease #pulmonaryfibrosis #fibroticILD
castbox.fm/app/castbox/...
castbox.fm/app/castbox/...
Impact of Environmental Exposures on the Development and Progression of Fibrotic Interstitial Lung Disease
<p>Dr. Mohleen Kang chats with Dr. Kerri Johannson and Dr. Tamera Corte about their article, "<a rel="nofollow"href="https://www.ats...
castbox.fm
June 10, 2025 at 6:36 AM
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#Senescence #Fibrosis
p21 controls collagen #ExtraCellularMatrix deposition in Both Senescent & Proliferating cells in #PulmonaryFibrosis
p21 KO or shRNA⬇️bleomycin-induced lung fibrosis
⏬DNA damage
⏬Senescence
Cdk4-Rb modifies TGFβ/SMAD3 signaling!
#EMBOJ 2024
www.embopress.org/doi/full/10....
p21 controls collagen #ExtraCellularMatrix deposition in Both Senescent & Proliferating cells in #PulmonaryFibrosis
p21 KO or shRNA⬇️bleomycin-induced lung fibrosis
⏬DNA damage
⏬Senescence
Cdk4-Rb modifies TGFβ/SMAD3 signaling!
#EMBOJ 2024
www.embopress.org/doi/full/10....
October 23, 2024 at 12:00 PM
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Lung Function Course of Patients With #PulmonaryFibrosis After Initiation of Anti-Fibrotic Treatment: Real-World Data From the Dutch National Registry
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
April 3, 2025 at 1:30 AM
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This new study shows that inhibition of S1pr3 ameliorates bleomycin-induced #PulmonaryFibrosis (PF) by reducing #macrophage M2 polarization via the PI3K/Akt-Stat3 signaling pathway, indicating that S1pr3 may be a potential target for PF treatment.
#OpenAccess: www.sciencedirect.com/science/arti...
#OpenAccess: www.sciencedirect.com/science/arti...
March 16, 2025 at 1:30 PM
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Drs. @micrornax.bsky.social #MJSeasock, @ccoarfa.bsky.social et al identified a protein, #Let7, that keeps #pulmonaryFibrosis in check. @bcmhouston.bsky.social #BCMDeptMedicine @natcomms.nature.com #BCMGradSchool www.bcm.edu/news/let-7-i...
Let-7 is a key guardian of healthy lungs that keeps pulmonary fibrosis in check
Researchers at Baylor College of Medicine and collaborating institutions have uncovered a key molecular player that is involved in lung repair and in the...
www.bcm.edu
May 13, 2025 at 5:52 PM
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🫁 #PulmonaryFibrosis doesn’t always present loudly
it affects 15,000 Canadians, often progressing before a clear diagnosis is made.
This September, we emphasize early symptom recognition and equitable access to care.
📊 Source: Canadian Lung Association
it affects 15,000 Canadians, often progressing before a clear diagnosis is made.
This September, we emphasize early symptom recognition and equitable access to care.
📊 Source: Canadian Lung Association
September 8, 2025 at 1:40 PM
Everybody can reply
How opaque is ground glass on chest imaging?
Landmark trials in systemic sclerosis (SSc) and other subtypes of connective tissue disease-associated interstitial lung disease (CTD-ILD) have demonstrated the benefit of multiple immunosuppressants,...
thorax.bmj.com
April 25, 2025 at 7:00 AM
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#Autophagy defects (Lysosomal membrane permeability, Not autophagosome-lysosome fusion) mediates #Bleomycin-induced cellular #Senescence & Alveolar damage in🐭#PulmonaryFibrosis
A role of #ReactiveOxygenSpecies in Bleomycin-compromised autophagy
Autophagy 2024
www.tandfonline.com/doi/full/10....
A role of #ReactiveOxygenSpecies in Bleomycin-compromised autophagy
Autophagy 2024
www.tandfonline.com/doi/full/10....
ROS-mediated lysosomal membrane permeabilization and autophagy inhibition regulate bleomycin-induced cellular senescence
Bleomycin exhibits effective chemotherapeutic activity against multiple types of tumors, and also induces various side effects, such as pulmonary fibrosis and neuronal defects, which limit the clin...
www.tandfonline.com
June 9, 2024 at 12:45 AM
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Armed with positive topline results from its Phase I trial, Cereno plans to start Phase II trial for HDAC inhibitor CS014 as a treatment for idiopathic pulmonary fibrosis (IPF) in H1 2026.
#news #CerenoScientific #CS014 #FibrosisResearch #IPF #PulmonaryFibrosis #ClinicalTrials #BiotechNews
#news #CerenoScientific #CS014 #FibrosisResearch #IPF #PulmonaryFibrosis #ClinicalTrials #BiotechNews
Cereno’s IPF drug clears Phase I, paving way for Phase II
The company plans to start Phase II trial for HDAC inhibitor CS014 as a treatment for idiopathic pulmonary fibrosis (IPF) in H1 2026.
druganddeviceworld.com
July 22, 2025 at 11:28 AM
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