🚨PhD Opportunity Alert🚨 Join me, @suzieh.bsky.social and @walllabuoglasgow.bsky.social to investigate how environment shapes anti-phage defences & prophage–prophage conflict in Pseudomonas aeruginosa.
Apply here:
www.gla.ac.uk/postgraduate...
Apply here:
www.gla.ac.uk/postgraduate...
October 1, 2025 at 7:58 PM
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From earlier this week: A MRSA strain emerged ~2009 in Brooklyn, NY that is now a major cause of skin infections in the US.
Bo Shopsin & team discover a prophage-encoded methyltransferase that increases virulence by promoting biofilm formation in a mouse infection model:
buff.ly/g0i2DGm
Bo Shopsin & team discover a prophage-encoded methyltransferase that increases virulence by promoting biofilm formation in a mouse infection model:
buff.ly/g0i2DGm
September 27, 2025 at 12:04 PM
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www.biorxiv.org/content/10.1...
#microsky #phagesky
Among the adaptations found in wound-adapted Pseudomonas aeruginosa to compensate for other pre-engineered mutations, there’s the expanded number of Pf6 prophage copies.
#microsky #phagesky
Among the adaptations found in wound-adapted Pseudomonas aeruginosa to compensate for other pre-engineered mutations, there’s the expanded number of Pf6 prophage copies.
Pseudomonas aeruginosa biofilm-deficient mutants undergo parallel adaptation during chronic infection
Pseudomonas aeruginosa readily adapts to infection by acquiring stable and heritable mutations. Previously, we discovered that the first adaptations in a porcine wound model were rugose small-colony v...
www.biorxiv.org
September 22, 2025 at 5:28 AM
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Same strain, two genomes: Creating a consensus circular genome of Myxococcus xanthus DZ2 revealed the diversity of a large polyploid prophage region within the close-related myxobacterial strains https://www.biorxiv.org/content/10.1101/2024.12.30.630742v1
December 30, 2024 at 10:49 PM
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Ecology of prophage-like elements in Bacillus subtilis at global and local geographical scale https://www.biorxiv.org/content/10.1101/2024.07.03.601884v1
Ecology of prophage-like elements in Bacillus subtilis at global and local geographical scale https://www.biorxiv.org/content/10.1101/2024.07.03.601884v1
Prophages account for a substantial part of most bacterial genomes, but the impacts on hosts remain
www.biorxiv.org
July 4, 2024 at 5:16 AM
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The enemy from within: a prophage of Roseburia intestinalis systematically turns lytic in the mouse gut, driving bacterial adaptation by CRISPR spacer acquisition.
DOI: 10.1038/s41396-019-0566-x
https://pubmed.ncbi.nlm.nih.gov/31827247/
DOI: 10.1038/s41396-019-0566-x
https://pubmed.ncbi.nlm.nih.gov/31827247/
The enemy from within: a prophage of Roseburia intestinalis systematically turns lytic in the mouse gut, driving bacterial adaptation by CRISPR spacer acquisition - PubMed
Despite an overall temporal stability in time of the human gut microbiota at the phylum level, strong variations in species abundance have been observed. We are far from a clear understanding of what promotes or disrupts the stability of microbiome communities. Environmental factors, like food or an …
pubmed.ncbi.nlm.nih.gov
April 9, 2025 at 9:44 PM
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A prophage-encoded anti-phage defense system that prevents phage DNA packaging by targeting the terminase complex https://www.biorxiv.org/content/10.1101/2025.02.27.640495v1
February 28, 2025 at 3:20 AM
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Bacillus eDNA comes has a prophage source. Someone bet me.
December 3, 2024 at 3:46 AM
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A prophage-encoded single-stranded DNA-binding protein (SSBP) from S. aureus attenuates bacterial virulence and enhances macrophage activation via IL-6, new study reveals. SSBP boosts immune clearance and shows therapeutic potential. #MicroSky #Phage
✍️ Ahmad-Mansour & coll.
📖 shorturl.at/6yqFx
✍️ Ahmad-Mansour & coll.
📖 shorturl.at/6yqFx
June 17, 2025 at 4:06 AM
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Back in the lab for a quick bit of prophage induction. Just look at my beauties 🦠 #PhageSky
July 16, 2025 at 9:28 AM
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Unlocking prophage potential: In silico and experimental analysis of a novel Mycobacterium fortuitum LysinB containing a peptidoglycan-binding domain https://www.biorxiv.org/content/10.1101/2024.02.15.580446v1
Unlocking prophage potential: In silico and experimental analysis of a novel Mycobacterium fortuitum LysinB containing a peptidoglycan-binding domain https://www.biorxiv.org/content/10.1101/2024.02.15.580446v1
Endolysins are highly evolved bacteriophage-encoded lytic enzymes produced to damage the bacterial c
www.biorxiv.org
February 16, 2024 at 3:19 AM
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Huge thanks to @Cerebro409 and @akshayparopkari for really cool talks in our microbial genomics seminar! Not only did we learn some fascinating computational approaches to investigating prophage and TF binding distributions, but they gave incredible career advice to our ugrads!
November 6, 2024 at 6:13 AM
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Revisiting typing systems for group B Streptococcus prophages: an application in prophage detection and classification in group B Streptococcus isolates from Argentina https://pubmed.ncbi.nlm.nih.gov/39418095/
October 18, 2024 at 8:43 AM
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Directed evolution of bacteriophages: impacts of prolific prophage https://www.biorxiv.org/content/10.1101/2024.06.28.601269v1
Directed evolution of bacteriophages: impacts of prolific prophage https://www.biorxiv.org/content/10.1101/2024.06.28.601269v1
Various directed evolution methods exist that seek to procure bacteriophages with expanded host rang
www.biorxiv.org
June 30, 2024 at 6:17 AM
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Appelmans Protocol for in vitro Klebsiella pneumoniae phage host range expansion leads to induction of the novel temperate linear plasmid prophage vB_KpnS-KpLi5.
DOI: 10.1007/s11262-024-02124-0
https://pubmed.ncbi.nlm.nih.gov/39656380/
DOI: 10.1007/s11262-024-02124-0
https://pubmed.ncbi.nlm.nih.gov/39656380/
Appelmans Protocol for in vitro Klebsiella pneumoniae phage host range expansion leads to induction of the novel temperate linear plasmid prophage vB_KpnS-KpLi5 - PubMed
Adjuvant therapy with bacteriophage (phage) cocktails in combination with antibiotics is a therapeutic approach currently considered for treatment of infections with encapsulated, biofilm forming, and multidrug-resistant Klebsiella pneumoniae (Kp). Klebsiella phage are highly selective in targeting …
pubmed.ncbi.nlm.nih.gov
December 14, 2024 at 9:38 PM
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Genomic Dissection of Metabolism, Prophage Elements, and Ecological Adaptations in Candidatus Liberibacter asiaticus https://www.biorxiv.org/content/10.1101/2025.04.04.647159v1
April 8, 2025 at 3:45 AM
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E. coli prophages’ arsenal against temperate phages:
New work isolates temperate phages from diverse E. coli strains, enabling identification of 17 conserved, prophage-encoded anti-phage defense systems that protect against other temperate phages
www.cell.com/cell-host-mi...
New work isolates temperate phages from diverse E. coli strains, enabling identification of 17 conserved, prophage-encoded anti-phage defense systems that protect against other temperate phages
www.cell.com/cell-host-mi...
E. coli prophages encode an arsenal of defense systems to protect against temperate phages
Bacteria contain an array of immune systems, with many yet to be discovered. Brenes
and Laub isolate temperate phages from diverse E. coli strains, enabling identification
of 17 conserved, prophage-en...
www.cell.com
June 19, 2025 at 7:47 PM
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#meettheteam Today our spotlight is on prophages!
.... Or at least on our prophage guy. Meet Luis Tanoeiro (@ltanoeiro.bsky.social) a PhD candidate splitting his time between our lab and Bioisi (U. of Lisbon @cienciasulisboa.bsky.social) working with Filipa Vale's team
Prophages are COOL!!!
.... Or at least on our prophage guy. Meet Luis Tanoeiro (@ltanoeiro.bsky.social) a PhD candidate splitting his time between our lab and Bioisi (U. of Lisbon @cienciasulisboa.bsky.social) working with Filipa Vale's team
Prophages are COOL!!!
July 25, 2025 at 8:42 AM
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Daniel Maddock (@michhulin.bsky.social’s group) investigates prophage carrying a key effector protein that enables Pseudomonas bacteria to infect cherry trees.
Deleting the whole prophage reduces virulence of the bacterium on the plant (leaf and woody tissue) 🍒
#PlantHealth2025
Deleting the whole prophage reduces virulence of the bacterium on the plant (leaf and woody tissue) 🍒
#PlantHealth2025
August 5, 2025 at 12:22 AM
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🚀 Released gbdraw v0.6.0!
- Added dinucleotide skew plotting to linear mode. Fixed the bug where only GC skew could be drawn.
- Added links to relevant sections of the documentation throughout the web app help menu.
Try out:👉 gbdraw.streamlit.app
- Added dinucleotide skew plotting to linear mode. Fixed the bug where only GC skew could be drawn.
- Added links to relevant sections of the documentation throughout the web app help menu.
Try out:👉 gbdraw.streamlit.app
October 9, 2025 at 2:01 PM
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Working on phage research?
Dr. Catherine Hernandez and I are co-convening the "Phage Ecology: From Prophage Decision Making to Ecosystem Modulation" in-depth symposium at ASM Microbe 2025 and we want YOU to be part of it!
Abstract submission is now open!
More info below
🧪🦠🔬
#Phagesky
#Microsky
Dr. Catherine Hernandez and I are co-convening the "Phage Ecology: From Prophage Decision Making to Ecosystem Modulation" in-depth symposium at ASM Microbe 2025 and we want YOU to be part of it!
Abstract submission is now open!
More info below
🧪🦠🔬
#Phagesky
#Microsky
November 22, 2024 at 11:07 PM
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Prophage-DB: a comprehensive database to explore diversity, distribution, and ecology of prophages.
DOI: 10.1186/s40793-024-00659-1
https://pubmed.ncbi.nlm.nih.gov/39806487/
DOI: 10.1186/s40793-024-00659-1
https://pubmed.ncbi.nlm.nih.gov/39806487/
Prophage-DB: a comprehensive database to explore diversity, distribution, and ecology of prophages - PubMed
Given that prophages are particularly overlooked and merit increased attention due to their vital implications for microbiomes and their hosts, we created Prophage-DB to advance our understanding of prophages in microbiomes through a comprehensive characterization of prophages in publicly available …
pubmed.ncbi.nlm.nih.gov
February 8, 2025 at 5:39 AM
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Pangenomics to understand prophage dynamics in the Pectobacterium genus and the radiating lineages of P. brasiliense https://www.biorxiv.org/content/10.1101/2024.09.02.610764v1
Pangenomics to understand prophage dynamics in the Pectobacterium genus and the radiating lineages of P. brasiliense https://www.biorxiv.org/content/10.1101/2024.09.02.610764v1
Bacterial pathogens of the genus Pectobacterium are responsible for soft rot and blackleg disease in
www.biorxiv.org
September 3, 2024 at 5:46 AM
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The biology and ecological impact of #phages in the mammalian gut are poorly understood. This Primer explores a @plosbiology.org study that provides a glimpse into the disruptive biology of the #Hankyphages, parasites of the ubiquitous Bacteroidaceae. 🧪 Primer: plos.io/3RukgtJ Paper: plos.io/41Rr22S
April 2, 2025 at 4:44 PM
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Prophage intercepts pathogenic activity of infecting phage:
Antitermination during phage replication activates RemS/PokE, encoded in prophage. PokE, membrane-depolarizing protein embedded in prophage lysis cassette, disrupts phage lytic cycle
www.cell.com/cell-host-mi...
Antitermination during phage replication activates RemS/PokE, encoded in prophage. PokE, membrane-depolarizing protein embedded in prophage lysis cassette, disrupts phage lytic cycle
www.cell.com/cell-host-mi...
A prophage intercepts pathogenic activity of infecting phage for defense
Sargen and Helaine characterize how antitermination during phage replication activates
the expression of a small membrane-depolarizing protein embedded in the lysis cassette
of the prophage. This reve...
www.cell.com
October 17, 2025 at 4:17 PM
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