P.S. While "protein-only" editors (like those from David Liu) are highly effective, the programmability and versatility of a true CRISPR-based mtDNA system offers huge potential benefits—if we can improve efficiency and translate it to mammalian cells.
December 10, 2025 at 4:19 PM
P.S. While "protein-only" editors (like those from David Liu) are highly effective, the programmability and versatility of a true CRISPR-based mtDNA system offers huge potential benefits—if we can improve efficiency and translate it to mammalian cells.
Advert Lucky Dip: Oct 1978: Enterprise Programmable ad from Sinclair (more at @OldUKPrintAds.bsky.social) #zxspectrum #retrogaming
(+3-Volume Program Library; Carrying Case; 240 V mains adaptor; Duracell manganese alkaline battery; Operating Manual; and Fibre-tip pen)
«£25 the lot!»
(+3-Volume Program Library; Carrying Case; 240 V mains adaptor; Duracell manganese alkaline battery; Operating Manual; and Fibre-tip pen)
«£25 the lot!»
December 6, 2025 at 12:36 PM
Advert Lucky Dip: Oct 1978: Enterprise Programmable ad from Sinclair (more at @OldUKPrintAds.bsky.social) #zxspectrum #retrogaming
(+3-Volume Program Library; Carrying Case; 240 V mains adaptor; Duracell manganese alkaline battery; Operating Manual; and Fibre-tip pen)
«£25 the lot!»
(+3-Volume Program Library; Carrying Case; 240 V mains adaptor; Duracell manganese alkaline battery; Operating Manual; and Fibre-tip pen)
«£25 the lot!»
And without even the graphing aspect. Just the programmability and built in functions make it super useful. A Swiss army knife
November 29, 2025 at 1:53 AM
And without even the graphing aspect. Just the programmability and built in functions make it super useful. A Swiss army knife
I'm just curious, is it really Turing completeness you need or just programmability? Like I guess people dont want their config scripts to not terminate, so a total language could allow for more customisation without reaching Turing completeness
November 24, 2025 at 11:50 AM
I'm just curious, is it really Turing completeness you need or just programmability? Like I guess people dont want their config scripts to not terminate, so a total language could allow for more customisation without reaching Turing completeness
I mean, the funny thing is that in a lot of ways it’s almost returning to an earlier iteration of semi-fixed-function GPU programmability, which lets you get more bang for your buck for straightforward DSP stuff because you need a lot less overhead
November 24, 2025 at 8:07 PM
I mean, the funny thing is that in a lot of ways it’s almost returning to an earlier iteration of semi-fixed-function GPU programmability, which lets you get more bang for your buck for straightforward DSP stuff because you need a lot less overhead
So I don't consider Spotlight Golf a computer game; the claim has always been hyperbolic. Doron Swade in the book "Exploring the Early Digital" agrees with that assessment.
Still, I hope their machine makes it into the hands of someone who can restore it: I would love to see it in action.
Still, I hope their machine makes it into the hands of someone who can restore it: I would love to see it in action.
November 14, 2025 at 11:19 PM
So I don't consider Spotlight Golf a computer game; the claim has always been hyperbolic. Doron Swade in the book "Exploring the Early Digital" agrees with that assessment.
Still, I hope their machine makes it into the hands of someone who can restore it: I would love to see it in action.
Still, I hope their machine makes it into the hands of someone who can restore it: I would love to see it in action.
From America, 1982: Games and Computers & Accessories from Atari
(+Defender; Centipede; Pac-Man; Juggles' Rainbow; 400 home computer; and Communicator kit)
(+Defender; Centipede; Pac-Man; Juggles' Rainbow; 400 home computer; and Communicator kit)
November 11, 2025 at 4:15 PM
From America, 1982: Games and Computers & Accessories from Atari
(+Defender; Centipede; Pac-Man; Juggles' Rainbow; 400 home computer; and Communicator kit)
(+Defender; Centipede; Pac-Man; Juggles' Rainbow; 400 home computer; and Communicator kit)
Vaccine development is in its nanotechnology era. A new Perspective, part of a Special Feature with 14 papers, explores how nanotherapeutic design and modification are enabling rapid, personalized, and powerful vaccine strategies In PNAS: https://ow.ly/3ijJ50XnOjy
November 6, 2025 at 5:02 PM
Vaccine development is in its nanotechnology era. A new Perspective, part of a Special Feature with 14 papers, explores how nanotherapeutic design and modification are enabling rapid, personalized, and powerful vaccine strategies In PNAS: https://ow.ly/3ijJ50XnOjy
I used the programmability of the ti-83 to cheat on tests, and that was arguably a more important life skill than taking the tests properly would have imparted.
I suspect I ended up a programmer because I could learn to program on my TI-83 while zoning out in class, and couldn't learn any other career that way.
October 28, 2025 at 11:07 AM
I used the programmability of the ti-83 to cheat on tests, and that was arguably a more important life skill than taking the tests properly would have imparted.
Dear Santa Elon,
I’ve been very good this year. Yup! Umm Santa Elon, you kinda wanna rule the world. Rite? Ok can u figure out how to pivot Germany’s overcapacity to produce vehicles, into producing an alt to your Tesla‘s.Idk…maybe a car, with >combo programmability for i& combustion, driver control
I’ve been very good this year. Yup! Umm Santa Elon, you kinda wanna rule the world. Rite? Ok can u figure out how to pivot Germany’s overcapacity to produce vehicles, into producing an alt to your Tesla‘s.Idk…maybe a car, with >combo programmability for i& combustion, driver control
December 16, 2024 at 9:37 PM
Dear Santa Elon,
I’ve been very good this year. Yup! Umm Santa Elon, you kinda wanna rule the world. Rite? Ok can u figure out how to pivot Germany’s overcapacity to produce vehicles, into producing an alt to your Tesla‘s.Idk…maybe a car, with >combo programmability for i& combustion, driver control
I’ve been very good this year. Yup! Umm Santa Elon, you kinda wanna rule the world. Rite? Ok can u figure out how to pivot Germany’s overcapacity to produce vehicles, into producing an alt to your Tesla‘s.Idk…maybe a car, with >combo programmability for i& combustion, driver control
Decentralized AI is inevitable, but not here yet. 🔷 AI's potential is throttled by current blockchain limits. 🔷 True AI-blockchain talk requires an infrastructural revolution. 🔷 Scalability, programmability, reliability vital for autonomous agents.
December 21, 2024 at 4:44 PM
Decentralized AI is inevitable, but not here yet. 🔷 AI's potential is throttled by current blockchain limits. 🔷 True AI-blockchain talk requires an infrastructural revolution. 🔷 Scalability, programmability, reliability vital for autonomous agents.
It's day 22 of #QuantAdvent 2024 and behind today's window we look at how we enable organisations to tokenise deposits and add #programmability to money.
Read the full story here: quant.network/use-cases/pr...
View the calendar: quant.network/quant-advent...
Read the full story here: quant.network/use-cases/pr...
View the calendar: quant.network/quant-advent...
December 22, 2024 at 10:37 AM
It's day 22 of #QuantAdvent 2024 and behind today's window we look at how we enable organisations to tokenise deposits and add #programmability to money.
Read the full story here: quant.network/use-cases/pr...
View the calendar: quant.network/quant-advent...
Read the full story here: quant.network/use-cases/pr...
View the calendar: quant.network/quant-advent...
Makers with built-in programmability have saved my ass this entire century. But I do kinda miss that small-level-higher bliss of a lovingly prepared pot.
January 25, 2024 at 6:27 PM
Makers with built-in programmability have saved my ass this entire century. But I do kinda miss that small-level-higher bliss of a lovingly prepared pot.
RippleXDev Proposes WASM for XRPL Smart Contracts: Unlocking New Programmability Potential
RippleX conducted a two-phase analysis of various virtual machines (VMs) like EVM, Soroban, and Move to identify the best fit for XRPL. The team selected WASM due to its versatility, security, and…
RippleX conducted a two-phase analysis of various virtual machines (VMs) like EVM, Soroban, and Move to identify the best fit for XRPL. The team selected WASM due to its versatility, security, and…
RippleXDev Proposes WASM for XRPL Smart Contracts: Unlocking New Programmability Potential
RippleX conducted a two-phase analysis of various virtual machines (VMs) like EVM, Soroban, and Move to identify the best fit for XRPL. The team selected WASM due to its versatility, security, and compatibility with XRPL’s architecture. RippleX developers recently suggested the integration of WebAssembly (WASM) for smart contracts on the XRP Ledger (XRPL), which will bring the system much closer to achieving enhanced programmability.
coinbuzzfeed.com
January 28, 2025 at 12:40 PM
RippleXDev Proposes WASM for XRPL Smart Contracts: Unlocking New Programmability Potential
RippleX conducted a two-phase analysis of various virtual machines (VMs) like EVM, Soroban, and Move to identify the best fit for XRPL. The team selected WASM due to its versatility, security, and…
RippleX conducted a two-phase analysis of various virtual machines (VMs) like EVM, Soroban, and Move to identify the best fit for XRPL. The team selected WASM due to its versatility, security, and…
Will cryptocurrencies without smart contract capabilities die? 💀
Or can you survive without programmability?
Join us and co-host Zano, as well as sponsor Edge Wallet, for episode 19 of the Crypto Quorum, live this Thursday at 5pm UTC!
#dash #crypto
x.com/Dashpay/stat...
Or can you survive without programmability?
Join us and co-host Zano, as well as sponsor Edge Wallet, for episode 19 of the Crypto Quorum, live this Thursday at 5pm UTC!
#dash #crypto
x.com/Dashpay/stat...
x.com
August 13, 2025 at 12:00 AM
Will cryptocurrencies without smart contract capabilities die? 💀
Or can you survive without programmability?
Join us and co-host Zano, as well as sponsor Edge Wallet, for episode 19 of the Crypto Quorum, live this Thursday at 5pm UTC!
#dash #crypto
x.com/Dashpay/stat...
Or can you survive without programmability?
Join us and co-host Zano, as well as sponsor Edge Wallet, for episode 19 of the Crypto Quorum, live this Thursday at 5pm UTC!
#dash #crypto
x.com/Dashpay/stat...
BRC20, a Bitcoin token standard, just got a major upgrade – BRC2.0! 🚀 It now integrates the Ethereum Virtual Machine (EVM), bringing Ethereum-like programmability & composability to the Bitcoin blockchain. Activated at block 912,690. (CoinDesk) #BRC20 #Bitcoin #EVM
#crypto #blockchain #news
#crypto #blockchain #news
September 1, 2025 at 12:41 PM
BRC20, a Bitcoin token standard, just got a major upgrade – BRC2.0! 🚀 It now integrates the Ethereum Virtual Machine (EVM), bringing Ethereum-like programmability & composability to the Bitcoin blockchain. Activated at block 912,690. (CoinDesk) #BRC20 #Bitcoin #EVM
#crypto #blockchain #news
#crypto #blockchain #news
TBC: A High-Performance UTXO Smart Contract Chain Extending Bitcoin’s Architecture – The Bitcoin ecosystem is undergoing a structural shift as developers push for programmability, higher throughput, and secure cross-chain asset flows. TBC enters this landscape as a Bitcoin hard fork engineered to pr
TBC: A High-Performance UTXO Smart Contract Chain Extending Bitcoin’s Architecture
TBC enters this landscape as a Bitcoin hard fork engineered to preserve the core security assumptions of the original chain..
tmastreet.com
December 3, 2025 at 6:09 PM
TBC: A High-Performance UTXO Smart Contract Chain Extending Bitcoin’s Architecture – The Bitcoin ecosystem is undergoing a structural shift as developers push for programmability, higher throughput, and secure cross-chain asset flows. TBC enters this landscape as a Bitcoin hard fork engineered to pr
There are energy savings to be had by trading away various aspects of programmability.
CPU : GPU :: GPU : ???
Lots of great cos. vying to be the ??? above. It remains to be seen if any rival offers (say) a 5X efficiency improvement vs. future SIMT GPUs sufficient to overcome the GPU SW moat.
CPU : GPU :: GPU : ???
Lots of great cos. vying to be the ??? above. It remains to be seen if any rival offers (say) a 5X efficiency improvement vs. future SIMT GPUs sufficient to overcome the GPU SW moat.
November 20, 2024 at 3:37 PM
There are energy savings to be had by trading away various aspects of programmability.
CPU : GPU :: GPU : ???
Lots of great cos. vying to be the ??? above. It remains to be seen if any rival offers (say) a 5X efficiency improvement vs. future SIMT GPUs sufficient to overcome the GPU SW moat.
CPU : GPU :: GPU : ???
Lots of great cos. vying to be the ??? above. It remains to be seen if any rival offers (say) a 5X efficiency improvement vs. future SIMT GPUs sufficient to overcome the GPU SW moat.
Background from @juanbenet on how httpd -> patches -> apache, and how @ipfs is now going through this same explosion, & how composability & programmability power this next wave.
Big #IPVM shout outs!
#IPFSCamp #labweek22
Big #IPVM shout outs!
#IPFSCamp #labweek22
March 7, 2025 at 12:17 AM
Background from @juanbenet on how httpd -> patches -> apache, and how @ipfs is now going through this same explosion, & how composability & programmability power this next wave.
Big #IPVM shout outs!
#IPFSCamp #labweek22
Big #IPVM shout outs!
#IPFSCamp #labweek22
DECRYPT: Bank of England-Backed Project: CBDCs Could Enable 'Programmability' for Money: undefined
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Powered by 0xMonitor
April 15, 2023 at 4:52 PM
DECRYPT: Bank of England-Backed Project: CBDCs Could Enable 'Programmability' for Money: undefined
Powered by 0xMonitor
Powered by 0xMonitor
Bitcoin Token Protocol BRC20 Enables EVM-Style Smart Contracts With ‘BRC2.0’ Bitcoin’s evolution continues as it embraces advanced programmability with the introduction of BRC2.0. This pivotal.... @cosmicmeta.ai #BRC20
https://u2m.io/pUzCVzgA
https://u2m.io/pUzCVzgA
Bitcoin Token Protocol BRC20 Enables EVM-Style Smart Contracts With 'BRC2.0'
Discover how the BRC20 protocol brings EVM-style smart contracts to Bitcoin with BRC2.0. Explore the technology, benefits, and future of programmable assets on the Bitcoin blockchain.
cosmicmeta.ai
September 1, 2025 at 4:18 PM
Bitcoin Token Protocol BRC20 Enables EVM-Style Smart Contracts With ‘BRC2.0’ Bitcoin’s evolution continues as it embraces advanced programmability with the introduction of BRC2.0. This pivotal.... @cosmicmeta.ai #BRC20
https://u2m.io/pUzCVzgA
https://u2m.io/pUzCVzgA
After teaching a Petri dish to play Pong, researchers explore living‑neuron biocomputers as energy‑efficient AI alternatives, but programmability, longevity, and transparency challenges remain significant.
Are living brain computers the solution to AI’s biggest problem?
It’s not artificial intelligence, but actual intelligence. Living neurons can solve profound problems while being ‘one million times more energy efficient than silicon’, one researcher tells Anthony C...
www.the-independent.com
September 30, 2025 at 12:35 PM
After teaching a Petri dish to play Pong, researchers explore living‑neuron biocomputers as energy‑efficient AI alternatives, but programmability, longevity, and transparency challenges remain significant.
Pacemaker concerns aside, something ive been holding out for is temperature probe + programmability support on induction drop-in ranges.
AEG 9000 series isnt sold in the US but supposedly offers it.
Thermador/GE also have some probe options but they're both expensive or limited.
AEG 9000 series isnt sold in the US but supposedly offers it.
Thermador/GE also have some probe options but they're both expensive or limited.
November 13, 2025 at 8:20 PM
Pacemaker concerns aside, something ive been holding out for is temperature probe + programmability support on induction drop-in ranges.
AEG 9000 series isnt sold in the US but supposedly offers it.
Thermador/GE also have some probe options but they're both expensive or limited.
AEG 9000 series isnt sold in the US but supposedly offers it.
Thermador/GE also have some probe options but they're both expensive or limited.
i don't see why, you can preserve "programmability" while restricting the feature set to a fixed set of attrs, same with textures and such.
October 28, 2024 at 8:19 PM
i don't see why, you can preserve "programmability" while restricting the feature set to a fixed set of attrs, same with textures and such.