ORIGIN phase 3 trial: In an interim analysis of a clinical trial, atacicept, a fusion protein that binds and inhibits two cytokines thought to be central to the pathophysiology of IgA nephropathy, significantly reduced proteinuria. nej.md/3JEq8QL
@asnkidney.bsky.social | #KidneyWk
@asnkidney.bsky.social | #KidneyWk
November 6, 2025 at 2:55 PM
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🆕 Peripartum cardiomyopathy is now the leading cause of maternal death in many parts of the world.
A Seminar summarises current knowledge of peripartum cardiomyopathy genetics, pathophysiology, diagnostic approaches, medical management, and outcome: tinyurl.com/4pf365hh
A Seminar summarises current knowledge of peripartum cardiomyopathy genetics, pathophysiology, diagnostic approaches, medical management, and outcome: tinyurl.com/4pf365hh
November 3, 2025 at 12:02 PM
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PXD062941 🚨
Proteomic Discoveries in Hypermobile Ehlers Danlos Syndrome Reveals Insights into Disease Pathophysiology
🚨 New dataset alert! 🚨
Proteomic Discoveries in Hypermobile Ehlers Danlos Syndrome Reveals Insights into Disease Pathophysiology
🚨 New dataset alert! 🚨
November 3, 2025 at 11:00 PM
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What Post Exertional Malaise #PEM actually means - the delayed worsening of symptoms after exceeding a pathologically reduced energy threshold -
is now reframed as simple “fatigue after exertion” or a “drop in performance.”
The “Post” is stripped from PEM - and the pathophysiology along with it.
is now reframed as simple “fatigue after exertion” or a “drop in performance.”
The “Post” is stripped from PEM - and the pathophysiology along with it.
November 2, 2025 at 11:25 AM
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New review in The Nurse Practitioner Journal raises awareness of #SARS-Cov-2 persistence in Long COVID! ✨
LC patients are ALL too familiar with the experience of seeking out help from medical professionals - only to be met with confusion and doubt over what this disease is.
1/
LC patients are ALL too familiar with the experience of seeking out help from medical professionals - only to be met with confusion and doubt over what this disease is.
1/
November 1, 2025 at 5:29 PM
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A 1-week-old full-term baby boy was brought back to the hospital with discharge from his navel. Physical examination showed pink tissue at the umbilicus that seeped yellow liquid. Abdominal ultrasonography was performed. What is the underlying pathophysiology? nej.md/IC10302025
#MedSky
#MedSky
October 31, 2025 at 7:02 PM
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Altered Naᵥ1.9 channel activity in two Tyr66Ser variant carriers with small fiber dysfunction. new study from Noortje van den Braak, Maike Dohrn and colleagues @rwth.bsky.social: rupress.org/jgp/article/...
#Pathophysiology #MolecularPhysiology #Nerve
#Pathophysiology #MolecularPhysiology #Nerve
October 31, 2025 at 1:45 PM
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Summarizing the pathophysiology underlying #VascularAging & #ArterialStiffness, the resulting end-organ damage and methods for measuring arterial stiffness, with highlights on preventive & therapeutic strategies and future directions. #medsky
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
October 31, 2025 at 7:03 AM
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Interesting study & technology.
Hopefully it becomes widely available for clinical practice.
Blood Flow to the Head in a Person With Myalgic Encephalomyelitis Experiencing Postexertional Malaise: A Case Report
journals.lww.com/cptj/abstrac...
#MyalgicEncephalomyelitis #PwME #MEcfs #CFS
Hopefully it becomes widely available for clinical practice.
Blood Flow to the Head in a Person With Myalgic Encephalomyelitis Experiencing Postexertional Malaise: A Case Report
journals.lww.com/cptj/abstrac...
#MyalgicEncephalomyelitis #PwME #MEcfs #CFS
October 30, 2025 at 1:46 AM
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🏥 Early postoperative orthostatic intolerance: pathophysiology and clinical implications
🗨️Complex and multifactorial; advantages of early postoperative mobilization; awareness to reduce falls and delayed recovery. - Johanne Gormsen
➡️ buff.ly/fPoewrB
@bjsurgery.bsky.social #medsky #surgsky
🗨️Complex and multifactorial; advantages of early postoperative mobilization; awareness to reduce falls and delayed recovery. - Johanne Gormsen
➡️ buff.ly/fPoewrB
@bjsurgery.bsky.social #medsky #surgsky
BJS Academy
Joshi GP, Lobo DN, Kehlet H. BJS 2025; 112: znaf109.
www.bjsacademy.com
October 29, 2025 at 5:20 PM
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Proteomic discoveries in hypermobile Ehlers–Danlos syndrome reveal insights into disease pathophysiology October 2025 Griggs, Daylor, Petrucci et al
academic.oup.com/immunohorizo...
#EDS #hEDS #Hypermobility #HSD #Research #Science #Proteomics #Zebras #NEISvoid #Immunology
academic.oup.com/immunohorizo...
#EDS #hEDS #Hypermobility #HSD #Research #Science #Proteomics #Zebras #NEISvoid #Immunology
Proteomic discoveries in hypermobile Ehlers–Danlos syndrome reveal insights into disease pathophysiology
Abstract. Hypermobile Ehlers–Danlos Syndrome (hEDS) is a poorly understood connective tissue disorder that lacks molecular diagnostic markers. This study a
academic.oup.com
October 26, 2025 at 2:10 AM
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I was just reminded of this old video on how I think medicine's partitioning of the human body into 11 discrete organ systems is anachronistic and contributes to misunderstanding of pathophysiology & misdiagnosis of diseases that fall into the cracks between systems.
www.youtube.com/watch?v=tmSe...
www.youtube.com/watch?v=tmSe...
Organ Systems Are Dumb
YouTube video by Strong Medicine
www.youtube.com
October 24, 2025 at 6:52 PM
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Proposed contributors to Long COVID include
persistent viral infection
latent virus reactivation,
immune dysregulation
autoimmunity
gut microbiota alterations
mitochondrial dysfunction
endothelial injury and coagulation abnormalities
www.tandfonline.com/doi/full/10....
persistent viral infection
latent virus reactivation,
immune dysregulation
autoimmunity
gut microbiota alterations
mitochondrial dysfunction
endothelial injury and coagulation abnormalities
www.tandfonline.com/doi/full/10....
October 23, 2025 at 5:37 AM
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#Long-COVID, #Post-COVID und #PASC gehen häufig mit kognitiven Einschränkungen (Cog-LC) einher. Eine Studie aus Japan konnte jetzt zeigen, dass bei #Cog-LC die postsynaptische Dichte von AMPA-Rezeptoren in bestimmten Hirnregionen erhöht ist.
pubmed.ncbi.nlm.nih.gov/41036177/
doi.org/10.1093/brai...
pubmed.ncbi.nlm.nih.gov/41036177/
doi.org/10.1093/brai...
![Graphical Abstract des Papers "Systemic increase of AMPA receptors associated with cognitive impairment of long COVID" von Fujimoto et al.
Long COVID primarily presents with persistent cognitive impairment (Cog-LC), imposing a substantial and lasting global burden. Even after the pandemic, there remains a critical global need for diagnostic and therapeutic strategies targeting Cog-LC. Nevertheless, the underlying neural mechanisms remain poorly understood. Given the central role of synapses in brain function, investigation of synaptic molecular changes may provide vital insights into Cog-LC pathophysiology. In this study, we used [11C]K-2 PET to characterize the density of AMPA receptors (AMPARs) on the post-synaptic cell surface, which are crucial synaptic components in brain signalling. Statistical parametrical mapping was used to spatially normalize and apply independent t-test for a voxel-based comparison. We selected patients with Cog-LC (n = 30) based on Repeatable Battery for the Assessment of Neuropsychological Status assessed persistent cognitive impairment and healthy controls (n = 80) with no diagnosed neuropsychiatric disorders. The primary objective was to compare [11C]K-2 standardized uptake value ratio with white matter (SUVRWM) as a reference region between patients with Cog-LC and healthy controls, and to define the regional extent of differences. The secondary objective was to examine associations between [11C]K-2 SUVRWM and plasma concentrations of cytokines or chemokines. As an exploratory objective, we tested whether [11C]K-2 PET data could distinguish Cog-LC from healthy controls using a partial least squares based classification algorithm. A voxel-based comparison (P < 0.05, T > 1.66, one-tailed, false discovery rate control) and a volume of interests analysis (P < 0.05, Bonferroni multiple comparison) demonstrated that increased index of AMPAR density in large parts of the brains of patients with Cog-LC compared with that in healthy controls…](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:yxkip4xxf4mlialvuuoisc2w/bafkreiavn6zplwzhwj2f6tc6pt6drw3a5cjuhe5fesxfvz6ltx4ekqbfmi@jpeg)
October 22, 2025 at 9:57 PM
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NEW State of the Art Review: Advances in the pathophysiology, diagnosis, and management of celiac disease
www.bmj.com/content/391/...
www.bmj.com/content/391/...
October 15, 2025 at 4:43 PM
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An overview of the physiological functions of mitochondria, the molecular mechanisms driving the pathophysiology of mitochondrial diseases, recent advances in diagnostics and therapy, and future research directions in this field. #medsky
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
October 11, 2025 at 10:01 AM
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How big is too big for a street library?
October 10, 2025 at 7:52 AM
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Just screenshotting a part of this in case someone has a line to RFK
October 10, 2025 at 5:33 AM
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"Systemic increase of AMPA receptors associated with cognitive impairment of long COVID"
doi.org/10.1093/brai...
doi.org/10.1093/brai...
![graphical abstract for paper reading, "Abstract
Long COVID primarily presents with persistent cognitive impairment (Cog-LC), imposing a substantial and lasting global burden. Even after the pandemic, there remains a critical global need for diagnostic and therapeutic strategies targeting Cog-LC. Nevertheless, the underlying neural mechanisms remain poorly understood. Given the central role of synapses in brain function, investigation of synaptic molecular changes may provide vital insights into Cog-LC pathophysiology. In this study, we used [11C]K-2 PET to characterize the density of AMPA receptors (AMPARs) on the post-synaptic cell surface, which are crucial synaptic components in brain signalling. Statistical parametrical mapping was used to spatially normalize and apply independent t-test for a voxel-based comparison. We selected patients with Cog-LC (n = 30) based on Repeatable Battery for the Assessment of Neuropsychological Status assessed persistent cognitive impairment and healthy controls (n = 80) with no diagnosed neuropsychiatric disorders. The primary objective was to compare [11C]K-2 standardized uptake value ratio with white matter (SUVRWM) as a reference region between patients with Cog-LC and healthy controls, and to define the regional extent of differences. The secondary objective was to examine associations between [11C]K-2 SUVRWM and plasma concentrations of cytokines or chemokines. As an exploratory objective, we tested whether [11C]K-2 PET data could distinguish Cog-LC from healthy controls using a partial least squares based classification algorithm. A voxel-based comparison (P < 0.05, T > 1.66, one-tailed, false discovery rate control) and a volume of interests analysis (P < 0.05, Bonferroni multiple comparison) demonstrated that increased index of AMPAR density in large parts of the brains of patients with Cog-LC compared with that in healthy controls. A voxel-based correlation analysis also showed the brain regions where [11C]K-2 SUVRWM cor…](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:65akt7cpte3w53rawcjkzrwm/bafkreiaej4lv3zmj6gelxelcjdkr5weyt7h2gc3tidwyosvecubvndo6aa@jpeg)
October 9, 2025 at 12:50 PM
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Review @cp-immunity.bsky.social Obesity, diabetes, and inflammation: Pathophysiology and clinical implications
www.cell.com/immunity/ful... @danieljdrucker.bsky.social
www.cell.com/immunity/ful... @danieljdrucker.bsky.social
October 3, 2025 at 7:40 PM
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✅ Editor's Choice: This review on ulcerative colitis summarizes its epidemiology, pathophysiology, clinical presentation, diagnosis, and management.
💾 Save it for your bibliography: ja.ma/4pSd7Dr
💾 Save it for your bibliography: ja.ma/4pSd7Dr
October 3, 2025 at 2:00 PM
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Inflammation is a key driver of the pathophysiology of cardiometabolic disorders #obesity #T2D and new metabolic medicines based on GLP-1 action exert their magic in part by reducing inflammation. A new review from Professor Donath summarizes the field www.sciencedirect.com/science/arti...?
Obesity, diabetes, and inflammation: Pathophysiology and clinical implications
Obesity and its related disorders, including type 2 diabetes and liver, kidney, and cardiovascular diseases, are now recognized as chronic inflammator…
www.sciencedirect.com
October 3, 2025 at 3:23 PM
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Dr. Liz Kiernan talks us through "Endothelium in Kidney Health and Disease," by reviewing #kidney vasculature #physiology and eGFR, structure and function of #endothelium, #pathophysiology and signaling, #biomarkers and #therapeutics. @uwmedicine.bsky.social #nephsky
Watch: youtu.be/b1Nr0QRcVeQ
Watch: youtu.be/b1Nr0QRcVeQ
Elizabeth Kiernan, MD - Endothelium in Kidney Health and Disease
YouTube video by University of Washington Division of Nephrology
youtu.be
October 2, 2025 at 6:57 PM
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But anatomy and physiology is so weird and fun. it’s wild to know some of the basics (as an EMT, your understanding of physiology and pathophysiology is decent, but verrrry practical and basic, on a systemic level). but going into the cellular and biochem level feels like entering a new universe
October 1, 2025 at 3:29 AM
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I have to by law supervise highly seasoned third year residents who are functionally attendings and can explain complex pathophysiology to patients in clear language, and this guy is unsupervised practicing #medicine on millions of people
September 26, 2025 at 3:19 PM
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