How do pleiotropic TFs generate organized diversity in developing tissues? @spinalorga.bsky.social shows that PAX3 & PAX7 organize #SpinalCord by acting as both repressors & pioneer activators, regulated by #morphogens to ensure precise neural subtype specification @plosbiology.org 🧪 plos.io/4qumsla
October 27, 2025 at 5:25 PM
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How do pleiotropic TFs generate organized diversity in developing tissues? @spinalorga.bsky.social shows that PAX3 & PAX7 organize #SpinalCord by acting as both repressors & pioneer activators, regulated by #morphogens to ensure precise neural subtype specification @plosbiology.org 🧪 plos.io/4qumsla
October 27, 2025 at 1:58 PM
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How do pleiotropic TFs generate organized diversity in developing tissues? @spinalorga.bsky.social shows that PAX3 & PAX7 organize #SpinalCord by acting as both repressors & pioneer activators, regulated by #morphogens to ensure precise neural subtype specification @plosbiology.org 🧪 plos.io/4qumsla
October 27, 2025 at 9:55 AM
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Very exciting study! Given the role of th Golgi in exocytosis, this has possibly key implications on the establishement of mechanochemical feedback loops with secreted ligands such as morphogens or growth factors! Congratulations @felixmendu.bsky.social and to all authors 👏😀!!
September 30, 2025 at 8:03 AM
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Interested in morphogens and how they can robustly specifiy different cell types with single-cell resolution?
Check out this preprint combining experiments and modelling by our colleagues and partners in crime @ucl-cdb.bsky.social:
www.biorxiv.org/content/10.1...
Check out this preprint combining experiments and modelling by our colleagues and partners in crime @ucl-cdb.bsky.social:
www.biorxiv.org/content/10.1...
Morphogen and juxtacrine signalling dynamically integrate to specify cell fates with single-cell resolution
Morphogen gradients guide tissue patterning but do not act in isolation. How they integrate with other signalling modalities, like juxtacrine signalling, and how these integrations influence pattern r...
www.biorxiv.org
September 25, 2025 at 2:27 PM
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So juxtacrine and temporally dynamic signals can themselves carry and refine positional information, augmenting that provided by morphogens to enable robust, fine-grained patterning.
September 22, 2025 at 9:14 PM
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This is a great system to explore how morphogens drive patterns at high resolution: a Hh gradient specifies neuronal fate at the single cell resolution repeatedly in the Drosophila lamina. Or does it?
September 22, 2025 at 9:14 PM
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🚨New Preprint🚨
How do morphogens integrate dynamically with other modes of signalling+what can this do for pattern precision and robustness?
We used the Drosophila visual system as our muse to dive into this question with the amazing Vil Fernandes @ucl.ac.uk 🧠🪰 👇
www.biorxiv.org/content/10.1...
How do morphogens integrate dynamically with other modes of signalling+what can this do for pattern precision and robustness?
We used the Drosophila visual system as our muse to dive into this question with the amazing Vil Fernandes @ucl.ac.uk 🧠🪰 👇
www.biorxiv.org/content/10.1...
www.biorxiv.org
September 22, 2025 at 10:35 AM
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#Morphogens cooperate to guide development of the #cochlea. This Primer explores a @plosbiology.org study showing how #PlanarCellPolarity of individual cells is integrated across distinct regional compartments to ensure proper organ #morphogenesis. Paper: plos.io/4nmD8IW Primer: plos.io/3IjPkLR
September 11, 2025 at 1:34 PM
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#Morphogens cooperate to guide development of the #cochlea. This Primer explores a @plosbiology.org study showing how #PlanarCellPolarity of individual cells is integrated across distinct regional compartments to ensure proper organ #morphogenesis. Paper: plos.io/4nmD8IW Primer: plos.io/3IjPkLR
September 11, 2025 at 8:31 AM
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i- The size and geometry of extracellular space;
ii- Interactions of morphogens with cells through binding-unbinding or endo-/exocytosis;
iii- Mechano-osmotic effects associated with cell volume regulation and intercellular fluid flows.
ii- Interactions of morphogens with cells through binding-unbinding or endo-/exocytosis;
iii- Mechano-osmotic effects associated with cell volume regulation and intercellular fluid flows.
August 26, 2025 at 10:33 AM
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A few years ago, we introduced a new theoretical framework that treats tissues as biphasic poroelastic media. Through simulations, we demonstrated that the effective diffusion coefficient of morphogens essentially depends on:
August 26, 2025 at 10:31 AM
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Temporal coordination of tissue transformation, olfactory sensory neural development and central axon projections through morphogens https://www.biorxiv.org/content/10.1101/2025.07.21.666031v1
July 22, 2025 at 6:31 PM
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Temporal coordination of tissue transformation, olfactory sensory neural development and central axon projections through morphogens https://www.biorxiv.org/content/10.1101/2025.07.21.666031v1
July 22, 2025 at 6:31 PM
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I was interviewed recently by @stemcellpodcast.com
I witter on about morphogens, notochord, @dev-journal.bsky.social & how biology is becoming a data science
Thanks @stemcellpodcast.com for talking to me
stemcellpodcast.com/ep-299-spina...
I witter on about morphogens, notochord, @dev-journal.bsky.social & how biology is becoming a data science
Thanks @stemcellpodcast.com for talking to me
stemcellpodcast.com/ep-299-spina...
Ep. 299: "Spinal Cord Development" Featuring Dr. James Briscoe - The Stem Cell Podcast
Dr. James Briscoe is a Group Leader at the Francis Crick Institute and Editor-In-Chief of Development. His lab uses an interdisciplinary approach, including mice, chicks, and other models, to study de...
stemcellpodcast.com
July 9, 2025 at 8:00 AM
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Not a big believer in diffusion any more, at least on morphogens. Lots of targeted handoffs there. Not much actual diffusion. Relative concentration and on off rates for TF, yes.
July 7, 2025 at 3:30 PM
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Are you looking for a home for your research on stem cell biology and/or organoids? Our Associate Editor Aryeh Warmflash handles papers on these topics.
#ISSCR2025
Reasons to submit to JCS: journals.biologists.com/jcs/pages/re...
Subject Collection: journals.biologists.com/jcs/collecti...
#ISSCR2025
Reasons to submit to JCS: journals.biologists.com/jcs/pages/re...
Subject Collection: journals.biologists.com/jcs/collecti...
June 13, 2025 at 10:33 AM
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Do tissue material properties impact morphogen transport? Yes! And morphogens know it. Thanks to @nicolettapetridou.bsky.social who got us involved and to Bernat Corominas-Murtra, and kudos to @cami-autorino.bsky.social @dianakhorom.bsky.social and all the authors! 🧵 below if you are curious 👇
🔔 Proud to share the preprint of my PhD work in the Petridou group @nicolettapetridou.bsky.social @embl.org ✨
“A closed feedback between tissue phase transitions and morphogen gradients drives patterning dynamics” 🐟 🔁 📶
🔗 www.biorxiv.org/content/10.1...
#devbio #biophysics
🧵⤵️
“A closed feedback between tissue phase transitions and morphogen gradients drives patterning dynamics” 🐟 🔁 📶
🔗 www.biorxiv.org/content/10.1...
#devbio #biophysics
🧵⤵️
June 12, 2025 at 4:23 PM
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Here our latest work on how morphogens trigger tissue phase transitions to tune their own length-scales and time-scales - An exciting collaboration with @zhvas.bsky.social @dianakhorom.bsky.social Bernat Corominas-Murtra and heroic experiments by the incredible @cami-autorino.bsky.social @embl.org
🔔 Proud to share the preprint of my PhD work in the Petridou group @nicolettapetridou.bsky.social @embl.org ✨
“A closed feedback between tissue phase transitions and morphogen gradients drives patterning dynamics” 🐟 🔁 📶
🔗 www.biorxiv.org/content/10.1...
#devbio #biophysics
🧵⤵️
“A closed feedback between tissue phase transitions and morphogen gradients drives patterning dynamics” 🐟 🔁 📶
🔗 www.biorxiv.org/content/10.1...
#devbio #biophysics
🧵⤵️
June 11, 2025 at 5:24 PM
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🧵8/ ✨✨✨ We propose a conceptual framework of how patterning and tissue physical properties interact: morphogen-driven emergent mechanics may allow morphogens to quickly shape their own length-scales, ensuring that patterning is in sync with the rapidly-changing tissue architecture ✨✨✨
June 11, 2025 at 4:47 PM
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Start Small: A Model for Tissue-wide Planar Cell Polarity without Morphogens https://www.biorxiv.org/content/10.1101/2025.05.26.655839v1
May 30, 2025 at 2:33 PM
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Start Small: A Model for Tissue-wide Planar Cell Polarity without Morphogens https://www.biorxiv.org/content/10.1101/2025.05.26.655839v1
May 30, 2025 at 2:33 PM
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[Neurosciencenews.com]Two Key Signals Shape Brain Structure Early, Varying by Person - Neuroscience News A new study has revealed how two morphogens, WNT and Sonic Hedgehog, act as molecular "traffic cops," directing early human brain development.
May 7, 2025 at 5:01 PM
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[Neurosciencenews.com]Two Key Signals Shape Brain Structure Early, Varying by Person - Neuroscience News A new study has revealed how two morphogens, WNT and Sonic Hedgehog, act as molecular "traffic cops," directing early human brain development.
May 7, 2025 at 10:30 AM
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‘How molecular traffic cops guide development of the human brain’ – Yale-led study reveals how morphogens or ‘molecular traffic cops’ regulate development of stem cells into specialised brain cells: news.yale.edu/2025/05/01/h...
Paper: doi.org/10.1016/j.st...
@yalemed.bsky.social
Paper: doi.org/10.1016/j.st...
@yalemed.bsky.social
How molecular traffic cops guide development of the human brain
A new Yale study offers new insight into how morphogens help regulate the development of stem cells into specialized brain cells.
news.yale.edu
May 6, 2025 at 10:23 PM
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