To confirm this authors artificially increase Mark2 levels in mdx mice via a different route (using mice that do not have Akt protein, meaning Numb is activated to increase Mark2). This indeed improved the secondary proliferation in mdx mice and resulted in larger muscle fibers.
November 21, 2025 at 9:31 AM
To confirm this authors artificially increase Mark2 levels in mdx mice via a different route (using mice that do not have Akt protein, meaning Numb is activated to increase Mark2). This indeed improved the secondary proliferation in mdx mice and resulted in larger muscle fibers.
MARK2 is a protein involved in maintaining polarity. Dystrophin was expressed in wild type muscle, but reduced after proliferation. However, it was expressed in quiescent cells. Lacking dystrophin, mdx muscle had reduced levels of Mark2, which could be the cause of reduced secondary myogenesis.
November 21, 2025 at 9:29 AM
MARK2 is a protein involved in maintaining polarity. Dystrophin was expressed in wild type muscle, but reduced after proliferation. However, it was expressed in quiescent cells. Lacking dystrophin, mdx muscle had reduced levels of Mark2, which could be the cause of reduced secondary myogenesis.
Also the muscle fibers are smaller and there are less Pax7 and MyoG expressing cells (marker for satellite cells). Note that the differences are not that big, but there is a clear reduction. Authors performed single cell sequencing showing again reduced levels of committed muscle stem cells in mdx.
November 21, 2025 at 9:27 AM
Also the muscle fibers are smaller and there are less Pax7 and MyoG expressing cells (marker for satellite cells). Note that the differences are not that big, but there is a clear reduction. Authors performed single cell sequencing showing again reduced levels of committed muscle stem cells in mdx.
In the paper, authors analysis show that in mdx mice the development of primary myogenesis is slightly slower, but the numbers of primary myocytes are the same. However, during secondary myogenesis authors showed that in mdx mice there are less proliferating and less committed muscle stem cells
November 21, 2025 at 9:25 AM
In the paper, authors analysis show that in mdx mice the development of primary myogenesis is slightly slower, but the numbers of primary myocytes are the same. However, during secondary myogenesis authors showed that in mdx mice there are less proliferating and less committed muscle stem cells
Here they wanted to study the impact of less of dystrophin on muscle development in mouse embryos. For this they used wild type and mdx mice (no dystrophin) and a marker systems where early muscle progenitors are red and committed muscle stem cells are green.
November 21, 2025 at 9:18 AM
Here they wanted to study the impact of less of dystrophin on muscle development in mouse embryos. For this they used wild type and mdx mice (no dystrophin) and a marker systems where early muscle progenitors are red and committed muscle stem cells are green.
- Everything is good except the engine response — it feels a bit sluggish, and the QX60 would really benefit from a stronger V6. Compared with the MDX, the QX60 feels really underpowered.
VIEW VIDEO REED INFO
VIEW VIDEO REED INFO
2026 Infiniti QX60 Light Path: Exclusive Exterior Lighting Features | ShortsCars
- Everything is good except the engine response — it feels a bit sluggish, and the QX60 would really benefit from a stronger V6. Compared with the ...
shortscars.blogspot.com
November 20, 2025 at 5:45 PM
- Everything is good except the engine response — it feels a bit sluggish, and the QX60 would really benefit from a stronger V6. Compared with the MDX, the QX60 feels really underpowered.
VIEW VIDEO REED INFO
VIEW VIDEO REED INFO
AUTOSITY CU2417 Assembly Aluminum Core radiator .. • Compatible with select Acura and Honda models • AUTOSITY CU2417 Assembly Aluminum Core radiator Compatible with 2003-2004 Pilot, 2001-2002 MDX #Autos #ad
• This Radiator Replacement Boasts An Impressive 8 Out Of 5-star Rating, Based On Six Customer Reviews, Showcasing Its Exceptional Quality And Performance.
• Key features of this product include its precise fit, durable aluminum construction, and efficient cooling system performance.
kiitn.com
November 20, 2025 at 3:31 PM
AUTOSITY CU2417 Assembly Aluminum Core radiator .. • Compatible with select Acura and Honda models • AUTOSITY CU2417 Assembly Aluminum Core radiator Compatible with 2003-2004 Pilot, 2001-2002 MDX #Autos #ad
You know I'm not mad at the ZDX but the RDX and MDX are just unnecessary.
November 17, 2025 at 10:53 PM
You know I'm not mad at the ZDX but the RDX and MDX are just unnecessary.
We have two Accords and an MDX. I felt attacked.
November 16, 2025 at 10:47 PM
We have two Accords and an MDX. I felt attacked.
タイトル: DBA/2N-mdxマウスにおけるデュシェンヌ型筋ジストロフィーの運動障害の発見
実験対象: DBA/2N-mdxマウス
要点1: DBA/2N-mdxマウスは運動量が有意に減少し、暗い時期における活動的期間が短縮している。
要点2: 歩行距離が短縮し、スピードが遅く、直線歩行中の体の伸展が減少している。
実験対象: DBA/2N-mdxマウス
要点1: DBA/2N-mdxマウスは運動量が有意に減少し、暗い時期における活動的期間が短縮している。
要点2: 歩行距離が短縮し、スピードが遅く、直線歩行中の体の伸展が減少している。
Uncovering motor impairments in duchenne muscular dystrophy: 24-hour automated behavioral analysis of DBA/2N-mdx mice.
【J Pharmacol Sci】<AbstractText>Duchenne muscular dystrophy (DMD) is a severe X-linked genetic disorder caused by mutations in t...
pubmed.ncbi.nlm.nih.gov
November 16, 2025 at 3:49 PM
タイトル: DBA/2N-mdxマウスにおけるデュシェンヌ型筋ジストロフィーの運動障害の発見
実験対象: DBA/2N-mdxマウス
要点1: DBA/2N-mdxマウスは運動量が有意に減少し、暗い時期における活動的期間が短縮している。
要点2: 歩行距離が短縮し、スピードが遅く、直線歩行中の体の伸展が減少している。
実験対象: DBA/2N-mdxマウス
要点1: DBA/2N-mdxマウスは運動量が有意に減少し、暗い時期における活動的期間が短縮している。
要点2: 歩行距離が短縮し、スピードが遅く、直線歩行中の体の伸展が減少している。
My real-time reaction to learning what MDX is right this very instance: "OK so what it's just Markdown but with JS? lol nah that can't just be it? is it really that stupid!? oh for fucks sake why why whyyyyyyyyyyyyyy"
November 14, 2025 at 8:27 PM
My real-time reaction to learning what MDX is right this very instance: "OK so what it's just Markdown but with JS? lol nah that can't just be it? is it really that stupid!? oh for fucks sake why why whyyyyyyyyyyyyyy"
MDX is an abomination built on the original sin of Markdown, and I'm tired of pretending this isn't a horrible experience
November 14, 2025 at 8:24 PM
MDX is an abomination built on the original sin of Markdown, and I'm tired of pretending this isn't a horrible experience
beyond that, Directus is quite ok but MDX has to be mocked (as code blocks or something like that)
and then all the usual DIY options (and I'm with @woodyrew.bsky.social re: ByteMD) bsky.app/profile/fubi...
and then all the usual DIY options (and I'm with @woodyrew.bsky.social re: ByteMD) bsky.app/profile/fubi...
November 13, 2025 at 10:39 PM
beyond that, Directus is quite ok but MDX has to be mocked (as code blocks or something like that)
and then all the usual DIY options (and I'm with @woodyrew.bsky.social re: ByteMD) bsky.app/profile/fubi...
and then all the usual DIY options (and I'm with @woodyrew.bsky.social re: ByteMD) bsky.app/profile/fubi...
I fear there are indeed not too many low-effort options.
- for MDX, TinaCMS (Git-based) works well. But I only used it with Astro. tina.io/docs/feature...
- in-Browser VSCode with Plugins is ok: docs.github.com/en/codespace...
- best writing UX is Notion (+ Notion API / notion-to-md for CMS-like DX)
- for MDX, TinaCMS (Git-based) works well. But I only used it with Astro. tina.io/docs/feature...
- in-Browser VSCode with Plugins is ok: docs.github.com/en/codespace...
- best writing UX is Notion (+ Notion API / notion-to-md for CMS-like DX)
November 13, 2025 at 10:35 PM
I fear there are indeed not too many low-effort options.
- for MDX, TinaCMS (Git-based) works well. But I only used it with Astro. tina.io/docs/feature...
- in-Browser VSCode with Plugins is ok: docs.github.com/en/codespace...
- best writing UX is Notion (+ Notion API / notion-to-md for CMS-like DX)
- for MDX, TinaCMS (Git-based) works well. But I only used it with Astro. tina.io/docs/feature...
- in-Browser VSCode with Plugins is ok: docs.github.com/en/codespace...
- best writing UX is Notion (+ Notion API / notion-to-md for CMS-like DX)
Just shipped a new mini personal site template. No MDX, just a simple way to showcase your projects, bookmarks, and favorite music. Hope you like it.
design.intentui.com/products/sim...
design.intentui.com/products/sim...
Simple personal website template
A clean personal website template built with Next.js 16, perfect for sharing what you are into right now.
design.intentui.com
November 13, 2025 at 12:06 PM
Just shipped a new mini personal site template. No MDX, just a simple way to showcase your projects, bookmarks, and favorite music. Hope you like it.
design.intentui.com/products/sim...
design.intentui.com/products/sim...
📌What does it mean to research responsibly in spaces of displacement & crisis?
My new blog, 'Research and Responsibility: Lessons from Lesvos', reflects on ethics, extractivism & epistemic colonialism in border research. www.mdx.ac.uk/mdx-voices/r...
My new blog, 'Research and Responsibility: Lessons from Lesvos', reflects on ethics, extractivism & epistemic colonialism in border research. www.mdx.ac.uk/mdx-voices/r...
Research and Responsibility: Lessons from Lesvos
Dr Evgenia Iliadou a Visiting Fellow at the Middlesex University Graduate School shares research about the refugee crisis in Lesvos
www.mdx.ac.uk
November 12, 2025 at 4:37 PM
📌What does it mean to research responsibly in spaces of displacement & crisis?
My new blog, 'Research and Responsibility: Lessons from Lesvos', reflects on ethics, extractivism & epistemic colonialism in border research. www.mdx.ac.uk/mdx-voices/r...
My new blog, 'Research and Responsibility: Lessons from Lesvos', reflects on ethics, extractivism & epistemic colonialism in border research. www.mdx.ac.uk/mdx-voices/r...
November 12, 2025 at 2:42 PM
shipped a new MDX Website template 📝
> Next.js 16 App Router
> Velite for type-safe content
> copy posts as markdown for the llms
> code blocks with copy button
> shadcn/ui components
> craft-ds for design system
folder structure = your URLs. no config needed.
perfect for blogs, docs, portfolios.
> Next.js 16 App Router
> Velite for type-safe content
> copy posts as markdown for the llms
> code blocks with copy button
> shadcn/ui components
> craft-ds for design system
folder structure = your URLs. no config needed.
perfect for blogs, docs, portfolios.
November 11, 2025 at 2:03 PM
shipped a new MDX Website template 📝
> Next.js 16 App Router
> Velite for type-safe content
> copy posts as markdown for the llms
> code blocks with copy button
> shadcn/ui components
> craft-ds for design system
folder structure = your URLs. no config needed.
perfect for blogs, docs, portfolios.
> Next.js 16 App Router
> Velite for type-safe content
> copy posts as markdown for the llms
> code blocks with copy button
> shadcn/ui components
> craft-ds for design system
folder structure = your URLs. no config needed.
perfect for blogs, docs, portfolios.
However, using a cardiac stress pathology in mdx mice can be used to make clear that there is already underlying pathology. Using isoproterenol authors observed less IgG uptake in BB pretreated mdx mice. A more severe stress system (handling and isoproterenol) reduced lethality.
November 11, 2025 at 7:30 AM
However, using a cardiac stress pathology in mdx mice can be used to make clear that there is already underlying pathology. Using isoproterenol authors observed less IgG uptake in BB pretreated mdx mice. A more severe stress system (handling and isoproterenol) reduced lethality.
Authors acknowledge that longer term treatments are needed. They did not observe toxicity during their initial test (no increases in liver damage markers). Authors then also tested the impact on cardiac pathology. This is difficult in young mdx mice as they do not have pathology yet.
November 11, 2025 at 7:28 AM
Authors acknowledge that longer term treatments are needed. They did not observe toxicity during their initial test (no increases in liver damage markers). Authors then also tested the impact on cardiac pathology. This is difficult in young mdx mice as they do not have pathology yet.