#imsky
Recompensation after HCV cure

🤔Achieved in 36.6% of patients

👍Lower risk for liver-related mortality and PVT

😐Does not change HCC risk (So keep on screening)

Let's hear it for DAA's, even in advanced liver disease

#GIsky #IMSky #Medsky
December 12, 2025 at 10:13 PM
THREAD

One Year of tracking research communication on @bsky.app

This time last year we officially added the Bluesky social platform to the places where we track research communication and article sharing.

Here are some of the most viral articles that gained traction in the last 12 months.
1/14
December 3, 2025 at 12:27 PM
Skynet, but for America’s health system?
The folks behind Medicare, CDC, and friends are wiring up one giant “robot brain” to run healthcare bureaucracy.
What could possibly go wrong?

New Unsloppable AI post (written by AI):

unsloppable.ai/2025/12/05/w...

#healthpolicy #medsky #imsky
When Skynet Gets a Healthcare Job
Imagine if the entire U.S. health bureaucracy—Medicare, NIH, CDC, FDA and friends—decided to share one giant robot brain. That is essentially what the Department of Health and Human Services (HHS) …
unsloppable.ai
December 5, 2025 at 7:23 PM
⚠️ Mild COVID, lasting damage: Long COVID w/ cognitive symptoms shows brain atrophy, iron buildup, CSF barrier changes, and injury markers (↑GFAP/NfL)—confirmed twice. Protect your brain. www.nature.com/articles/s41...
#LongCOVID #BlueSky #MedSky #NewsSky #IDSky #SciSky #NurseSky #PedsSky #IMSky
Distinct brain alterations and neurodegenerative processes in cognitive impairment associated with post-acute sequelae of COVID-19 - Nature Communications
Post-acute sequelae of SARS-CoV-2 (PASC) have been linked to brain alterations, but association with cognitive problems are not well understood. Here, the authors analyze blood proteins and brain MRI ...
www.nature.com
November 30, 2025 at 12:33 AM
Commercial payors pay PCPs lower than PCPs employed by large systems — and often below Medicare and Medicaid rates.

https://pubmed.ncbi.nlm.nih.gov/41044451/

#healthpolicy #medsky #imsky
November 30, 2025 at 4:53 PM
The truth and nothing but the truth...PEth

🤔Phosphatidylethanol (PEth) detects ETOH exposure up to 12 days after a binge, up to 4 weeks with heavy use

🤔Reported ETOH consumption may not be accurate

🤔Useful to help sort out MASLD; MetALD, ALD

See flow sheets below

#IMsky #GIsky #Medsky
November 28, 2025 at 7:21 PM
GLP-1's...GI safety better than we thought??

🤔🔼 risk of cholelithiasis by 2cases/1,000
🔼 risk of reflux by 4/1,000

😀No apparent increase in cholecystitis, cholangitis, pancreatitis, obstruction, ileus

There ain't no perfect drug, but this one has real benefits

#IMsky #Medsky #GIsky
November 27, 2025 at 1:22 PM
A reminder: Early CCY after ERCP

🤔Although guidelines rec: Early CCY (same admission), only done about half the time

🤔Study: ACG Scientific Meeting

😒Biliary comps in 23% delayed, vs 0.8% early ccy

🔑: Risk NOT mitigated by sphincterotomy or stenting.

Carpe Diem:

#gisky #medsky #imsky
November 25, 2025 at 11:29 PM
Steatotic liver disease: worldwide problem

🤔Global incidence 37.5%; Mostly MASLD; MedALD 4%; ALD 2.2%

🤔Highest in Region of the Americas (56%)

🤔While high in T2Dm (70%); T1DM only 29.6%

It is out there...we just have to hunt it down.

#Imsky; #Medsky
November 24, 2025 at 2:33 PM
Arguments with Neph. Rectal NSAIDS and AKI

🤔Rectal NSAIDS decrease ERCP Pancreatitis

🤔Study with stage 1-3b CKD >7,000 pts each group

👍NO difference in aki and group with NSAIDS less post-ERCP pancreatitis. (Abstract at ACG)

Once got trashed for doing this.😟

#GIsky #IMsky #MEDsky
November 8, 2025 at 11:33 PM
The "little blue pill" returns...Exercise induced colon ischemia

🤔Seen in distance runners
🤔Likely due to vasoconstriction
🤔Difficult to prevent at times

👍Novel use of sildenafil and fludrocortisone worked.

Nice review and discussion of workup.

#IMsky #Medsky #GISky
October 30, 2025 at 11:18 AM
Eosinophilic Esophagitis. Patient handout

🤔Had posted on EoE days ago

👍Perhaps useful with your patients: ACG handout on EoE.

#medsky #IMsky #GIsky
October 29, 2025 at 11:13 PM
Is Shorter better? Esophageal variceal bleed
due to portal hypertension

🤔Always wondered about value of 5 days of Octreotide after successfully banding varices

😀Study: 1 vs 5 days Rx: No difference in 5 day re-bleeding or 6 week re bleeding and all cause mortality

#GIsky #IMsky #medsky
October 28, 2025 at 11:08 AM
Unusual case in Gastro:

16yo: obstipation, 🔼 lfts, ileus, 🔼calcium

Athlete on Ayurvedic supplements (Bhasmas) from incineration of metals and minerals,and Shilajit resin from mountain rocks

All available on Amazon

Lead level 🔼

Resolved with chelation

#IMsky #Medsky #GIsky
October 20, 2025 at 11:14 PM
Delta Hep: 3 articles/one editorial CinGastro&Hep

🤔Only testing 4.9% meeting AASLD Criteria

🤔HDV associated with markedly 🔼 HCC

🤔Can use PAGE-8 score (or FIB-4) to predict HCC
(On Medscape Reach-B score)

Identifying D important with new meds coming out, and interferon

#IMsky #GISky #Medsky
October 18, 2025 at 1:00 PM
The Renal Tubular Acidosis simplified table from UpToDate 🤩 #IMsky
November 21, 2024 at 5:34 AM
Hey #IMsky #primarycaresky #familymedicinesky #pediatricssky

What he 👇👇 said

The happiness of foundational primary care docs is a prime (indivisible!) determinant in anything calling itself a #healthcare system

There remain accelerants to our dwindling which MUST be addressed
Really really hard to run a health system without primary care clinicians - collective empowerment for better working conditions and more autonomy to respond to patients. @aafp.bsky.social
Hey #primarycaresky #internalmedicinesky #IMsky #medsky

Couldn’t be #IMProud -er of our @acpimphysicians.bsky.social .

Really happy/hopeful w this policy stance re options for IM physician organization in interest of patient access/care/our #wellness !!

www.acpjournals.org/doi/10.7326/...
May 2, 2025 at 5:04 PM
CRC Screening...remains a quandry

🤔Multitarget Stool DNA (Cologuard) at U.Pitt

😟Only 54.7% completed the test

Previous studies 87%-72% of positives undergo Colonoscopy
(Also disappointing)

Best approach to CRC screening remains a puzzle

#IMsky #GIsky #Medsky
October 5, 2025 at 7:32 PM
Large R Pleural Effusion

Cirrhosis but no evid of Portal Hypertension
Hx CHF (stable)

Alb gradient 1.6 🔼
+Tc-99m peritoneal cavity scintigraphy

Hepatic Hydrothorax can occur in absence of ascites, but also in absence of other signs of portal hypertension.

Rx challenging

#GIsky #IMsky #Medsky
September 30, 2025 at 10:26 PM
🩸 Polycythemia workup algorithm #hemesky #MedSky #IMsky #polycythemia
November 29, 2024 at 1:14 PM
E. coli, Klebsiella spp, Enterococcus spp, S. pneumo, and Coagulase-negative staph were the most prevalent infections.

Pseudomonas, Enterobacter, Serratia, Citrobacter, Strep anginosus were among the least prevalent (3-6 patients each).

Looking forward to future studies! #MedSky #IMsky #IDsky
November 24, 2024 at 1:20 AM
Lesson from this past week:

Isolated elevation of anticardiolipin IgM does not meet laboratory criteria for antiphospholipid syndrome! According to EULAR 2023 guidelines below. #medsky #IMsky #rheumsky #hemesky #antiphospholipid #thrombosis
August 6, 2025 at 3:34 AM
January 21, 2025 at 1:34 PM
At the SEMI VTE meeting, management of VTE in trans persons has been discussed.
Hormonal therapy may pose a challenge when facing anticoagulation.
What is your usual practice in these cases?

An interesting paper that has been mentioned:
tinyurl.com/VTEtran

#VTESky #thrombosis #HemeSky #IMSky #VTE
Thrombophilia and hormonal therapy in transgender persons: A literature review and case series
Background: Venous thromboembolism (VTE) is a rare side effect of hormonal therapy in transgender persons. Prothrombotic genetic variants can increase this risk. For this reason, previous VTE and/or g...
tinyurl.com
November 22, 2024 at 8:36 AM
A colleague just told me he couldn’t even respond to an email about a career forum because of the zero-communication policy of the administration. Physicians need to be organizing and advocating.

#imsky #medsky
January 31, 2025 at 1:59 AM