🔥Hot Off the Press | GRAPE: #DirectedEvolution in #Plants
A #Science study shows GRAPE enables fast, versatile directed evolution in planta. Evolved NLR NRC3 escapes nematode inhibition; rice NLR Pikm-1 recognizes 6 AVR-Pik alleles. Boosts plant breeding.
ow.ly/ZlMQ50XyUek

GRAPE is a new platform for in planta directed evolution. For this, it uses geminivirus rolling circle replication achieving high-throughput selection for desired gene activities.🌱

doi.org/10.1126/scie...

#iGEM2026#SynBio#directedevolution

✨Scientists are *evolving* genes in the lab! 🧬 Mimicking nature's power to create & refine proteins.🤯 What will they engineer next? #DirectedEvolution

Source: https://phys.org/news/2025-10-rapid-scalable-platform-enables-evolution.html

Our new paper on AI-generated TrpBs with @anima-anandkumar.bsky.social. GenSLM generated very useful promiscuous TrpB #enzymes, bypassing a lot of #directedevolution! great work by the whole team, especially Theophile Lambert. www.biorxiv.org/content/10.1...

📅July 7-11
The 2025 Onassis Lectures in Biology and Chemistry will be held @forth-ite.bsky.social, Heraklion, Crete. This year’s Lectures are devoted to the advances, challenges, and future prospects of #Re-engineeringBiology through #DirectedEvolution and #Synthetic cellular pathways.

Join us! We are looking for a new team member (PhD student) with strong background in organic chemistry.
🙏 RETWEET (We want to recruit internationally)

Organic chemistry meets #DirectedEvolution
Highly interdisciplinary & passionate research group

uni-bielefeld.hr4you.org/job/view/433...

Ammonia is key to fertilizers and essential to feed the world.🌍Its industrial production consumes ~2% of the global energy.
In this fully funded PhD project, you'll combine #enzymedesign and #directedevolution to turn nitrogen into ammonia.💡🌱

A huge thanks to my past and present group members, mentors, and collaborators who have supported this journey!

#Biocatalysis #EnzymeEngineering #Photoenzymes #SustainableChemistry #DirectedEvolution #ComputationalBiology #ProteinDesign #Hiring #PhDPositions

🌍 Exciting news! This summer, my group joins @mpimicrobiomarburg.bsky.social l to create photoenzymes for solar energy conversion & carbon capture. With #ProteinDesign 🖥️ & #DirectedEvolution 🧬, we’ll push enzyme design to new limits for a sustainable future!

#Hiring www.mpg.de/24336572/phd...

Check out our new review we wrote with @shaunmckinnie.bsky.social @robbieshepherd.bsky.social pubs.rsc.org/en/content/a... looking at the interface of MS for screening large mutant libraries like those associated with #directedevolution @ucscscicomm.bsky.social

Yeah, like this!

Very relevant to #DirectedEvolution and what transition vs. transversion mutations do if they happen at the 2nd base.

New paper from our lab @elife.bsky.social . We show how #DirectedEvolution reshaped #CRISPR for expanding DNA recongition.
This is work by Kazi Hossain, an incredibly talented student visiting my lab from the Czub lab, now in Orozco's lab & Lukasz Nierzwicki.
doi.org/10.7554/eLif...

We have a great PhD program across many disciplines, including #proteinengineering, #directedevolution, #machinelearning, #biocatalysis, #enzymes, and much more.

This is a very good, succinct description of the problem! I gave it to my group to read. #directedevolution #enzymes #AI4proteins