Emergence of antiphage functions from random sequence libraries reveals mechanisms of gene birth | PNAS
De novo gene birth—the emergence of genes from nongenic sequences—drives biological
innovation, yet its adaptive potential remains poorly understoo...
www.pnas.org
October 18, 2025 at 9:57 AM
Everybody can reply
13 reposts
27 likes
3 saves
Adsorption of phage T2 is inhibited due to inversion of cryptic prophage DNA by the serine recombinase PinQ
Abstract. Recombinases catalyze site-specific integration, excision, and inversion of DNA and are often found adjacent to anti-phage system genes clustered
academic.oup.com
October 16, 2025 at 5:11 PM
Everybody can reply
6 reposts
4 quotes
15 likes
1 saves
Now published: EnVhogDB, a large database of viral protein family HMM profiles to help functional annotation of new phage genomes - peercommunityjournal.org/articles/10....
EnVhogDB: an extended view of the viral protein families on Earth through a vast collection of HMM profiles
peercommunityjournal.org
October 18, 2025 at 7:58 AM
Everybody can reply
17 reposts
31 likes
8 saves
Very excited to share the latest work from our lab, which was published today in Nature!
nature.com/articles/s41...
PhD graduate and now post-doc Sofia Dahlman, along with co-senior author Sam Forster from The Hudson and other researchers from our lab and others.
nature.com/articles/s41...
PhD graduate and now post-doc Sofia Dahlman, along with co-senior author Sam Forster from The Hudson and other researchers from our lab and others.
Isolation, engineering and ecology of temperate phages from the human gut - Nature
Human host-associated cellular products may act as induction agents for bacteriophages.
nature.com
October 16, 2025 at 4:33 AM
Everybody can reply
10 likes
Systematic genome-wide mapping of host determinants of bacteriophage infectivity
Chitboonthavisuk et al. present PHAGEPACK, a CRISPRi-based screen that links host
gene perturbations to phage fitness via a phage packaging-based readout. Applied in
permissive and non-permissive E. c...
www.cell.com
October 16, 2025 at 6:49 AM
Everybody can reply
3 reposts
9 likes
Finished up this beanie earlier today. It's a slightly modified version of the Phage beanie. #crochet #menwhocrochet #queercrochet #woolyarn #handmade
October 17, 2025 at 6:32 PM
Everybody can reply
14 likes
Isolation, engineering and ecology of temperate phages from the human gut - Nature
Human host-associated cellular products may act as induction agents for bacteriophages.
www.nature.com
October 16, 2025 at 1:43 PM
Everybody can reply
3 reposts
7 likes
Very cool phage study from @jeremyjbarr.bsky.social's lab.
Isolation, engineering and ecology of temperate phages from the human gut
#microbiomesky #phagesky
Isolation, engineering and ecology of temperate phages from the human gut
#microbiomesky #phagesky
Isolation, engineering and ecology of temperate phages from the human gut - Nature
Human host-associated cellular products may act as induction agents for bacteriophages.
www.nature.com
October 15, 2025 at 9:26 PM
Everybody can reply
6 reposts
14 likes
Season 1 Episode 4 "The Phage."
Wife, "She's just gonna throw herself into danger every episode isnt she? Just send THE most important people to the dangerous planet."
me, "I mean... yeah. That's Star Trek." lol
Wife, "Oh no, I like Neelix, he's fun."
So much win. ☝🏻💚
Wife, "She's just gonna throw herself into danger every episode isnt she? Just send THE most important people to the dangerous planet."
me, "I mean... yeah. That's Star Trek." lol
Wife, "Oh no, I like Neelix, he's fun."
So much win. ☝🏻💚
Wife's thoughts on Voyager last night:
Is Captain Janeway supposed to be lady Captain Kirk? Cause she's a little over the top.
Are she & Chakotay gonna be a thing?
Neelix lied about being an expert so he can get on the ship didn't he?
There's a BUNCH of technobabble in this.
Is Captain Janeway supposed to be lady Captain Kirk? Cause she's a little over the top.
Are she & Chakotay gonna be a thing?
Neelix lied about being an expert so he can get on the ship didn't he?
There's a BUNCH of technobabble in this.
Continuing our Voyager watch. Episode 3 and the wife already seems to be enjoying herself more. She thinks it's cute. Am I disappointed she didnt like DS9? Sure. But plenty of Star Trek to go around.
October 17, 2025 at 4:48 AM
Everybody can reply
35 likes
Day 18, Bubble. One defence that bacteria have against phages is to produce extra cellular vesicles that act as decoys to which phages become irreversibly bound. #Drawtober #SciArt #PhageSky
October 18, 2025 at 7:50 PM
Everybody can reply
2 reposts
1 quotes
14 likes
Phages communicate across species to shape microbial ecosystems
Arbitrium is a communication system that helps bacteriophages decide between lysis and lysogeny via secreted peptides. In arbitrium, the AimP peptide binds its cognate AimR receptor to repress aimX ex...
www.biorxiv.org
October 14, 2025 at 6:52 AM
Everybody can reply
7 reposts
17 likes
3 saves
Day 17, Teeth. Phages may be able to infect and kill bacteria, but the bacteria are not defenceless and have evolved many varied phage defence systems to prevent infection, death or protect the bacterial community. #Drawtober #SciArt #PhageSky
October 17, 2025 at 4:25 PM
Everybody can reply
1 quotes
14 likes
1 saves
Amazing relatedness of telomerase with a bacterial anti-phage immunity system, from a new tree of reverse transcriptase. Group II introns are there too. Some of the most fascinating biological creatures have reverse transcriptase at their core.
Great stuff for my upcoming undergrad genome lectures!
Great stuff for my upcoming undergrad genome lectures!
7/10 We teamed up with RT aficionado @pentamorfico.bsky.social from the Rafa Pinilla-Redondo lab to build a new phylogenetic tree of RTs across all domains of life.
Remarkably, this revealed that the DRT enzymes are bacterial homologs of TERT.
Remarkably, this revealed that the DRT enzymes are bacterial homologs of TERT.
October 18, 2025 at 9:02 AM
Everybody can reply
1 reposts
4 likes
1 saves
Time for phage to shine
Antimicrobial resistance is responsible for some 1.2 million deaths a year a year and contributes to millions more. Data in the new report shows that the problem is growing at an alarming rate. n.pr/3J0HVBC
Study: We're losing the war against drug-resistant infections faster than we thought
Antimicrobial resistance is responsible for some 1.2 million deaths a year a year and contributes to millions more. Data in the new report shows that the problem is growing at an alarming rate.
n.pr
October 15, 2025 at 2:19 PM
Everybody can reply
2 likes
Horror Contig(artifact?) from my students' phage genome sequencing just in time for Halloween 🧪 #microsky
October 14, 2025 at 7:29 PM
Everybody can reply
1 reposts
10 likes
1 saves
Two intensive sampling periods of oyster-associated vibrio and their phage, 4 years apart, and many surprises. Despite being washed by the Atlantic, wide tides, and vibrio (almost?) disappearing most of the year, we can find the exact same virulent phages 4 years later (down to 0 SNP)! preprint👇
October 14, 2025 at 4:08 PM
Everybody can reply
19 reposts
1 quotes
35 likes
4 saves
Open position: Doctoral Researcher: “Remodeling of protein complexes during RNA phage infection”.
#science #career #jobs #sciencejobs #job #jobsearch #phd #phdposition
www.science.hr/jobs/212065/...
#science #career #jobs #sciencejobs #job #jobsearch #phd #phdposition
www.science.hr/jobs/212065/...
October 18, 2025 at 6:31 PM
Everybody can reply
1 reposts
2 likes
#sizesky #phagepost This entire con I've been plagued with intrusive thoughts of what it would be like to be a phage caught in the middle of a particularly wild room party... An apocalypse of hot sweaty twinks on a galactic scale... Hhhhhh
October 16, 2025 at 4:39 AM
Everybody can reply
1 reposts
16 likes
Between 2018–2023, antibiotic resistance increased in over 40% of the pathogen–antibiotic combinations monitored, with an average annual rise of 5–15%.
Resistance is highest in the WHO South-East Asian & Eastern Mediterranean Regions, where 1 in 3 reported infections were resistant 👉 bit.ly/438Ta1u
Resistance is highest in the WHO South-East Asian & Eastern Mediterranean Regions, where 1 in 3 reported infections were resistant 👉 bit.ly/438Ta1u
October 15, 2025 at 9:16 AM
Everybody can reply
1 reposts
2 likes
WHO reports 1 in 6 bacterial infections worldwide are antibiotic-resistant, with resistance rising sharply since 2018. Gram-negative bacteria like E. coli and K. pneumoniae pose the biggest threat. Action on #AMR surveillance and responsible antibiotic use is needed.
www.who.int/news/item/13...
www.who.int/news/item/13...
WHO warns of widespread resistance to common antibiotics worldwide
One in six laboratory-confirmed bacterial infections causing common infections in people worldwide in 2023 were resistant to antibiotic treatments, according to a new World Health Organization (WHO) r...
www.who.int
October 13, 2025 at 11:17 AM
Everybody can reply
2 reposts
3 likes
Day 15, Comfort. Phages are safe and protected away from UV light, heat and denaturing chemicals. Maybe they just need comfort of blankets and hot drinks to survive the autumn. #Drawtober #SciArt #PhageSky
October 15, 2025 at 7:54 PM
Everybody can reply
2 reposts
1 quotes
21 likes
Day 14, Clock 4/4. The release of new cyanophages is timed with dusk. At the end of the day infected cells are now full of new phages.
October 14, 2025 at 7:00 PM
Everybody can reply
2 reposts
1 quotes
6 likes
Good morning Phage [Ph]ans! I'm so stoked to share my first preprint with the @jrpenades.bsky.social lab! We show that phages can use the arbitrium system to crosstalk and regulate lysis-lysogeny, which has huge implications in how phages shape microbial communities!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Phages communicate across species to shape microbial ecosystems
Arbitrium is a communication system that helps bacteriophages decide between lysis and lysogeny via secreted peptides. In arbitrium, the AimP peptide binds its cognate AimR receptor to repress aimX ex...
www.biorxiv.org
October 14, 2025 at 11:59 AM
Everybody can reply
4 likes
Day 13, Loss 3/4. One of the phages finds a host, while the other losses out and perishes... #Drawtober #PhageSky #SciArt
October 13, 2025 at 3:23 PM
Everybody can reply
2 reposts
1 quotes
8 likes
Looking forward to this inaugural Conference on Bacteriophages: Biology, Dynamics, and Therapeutics,
Starting tomorrow.
www.iasusa.org/bacteriophag...
#phage #phagesky
Starting tomorrow.
www.iasusa.org/bacteriophag...
#phage #phagesky
Conference on Bacteriophages: Biology, Dynamics, and Therapeutics - IAS-USA
Physical Education: Bridging Clinical Research and Patient Care
www.iasusa.org
October 12, 2025 at 3:04 AM
Everybody can reply
1 quotes
9 likes
1 saves