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paperposterbot.bsky.social
arXiv📈🤖
Confidence intervals for maximum unseen probabilities, with application to sequential sampling design
By Colombi, Beraha, Painsky et al
Discovery problems often require deciding whether additional sampling is needed to detect all categories whose prevalence exceeds a prespecified threshold. We study this question under a Bernoulli product (incidence) model, where categories are observed only through presence--absence across sampling units. Our inferential target is the \emph{maximum unseen probability}, the largest prevalence among categories not yet observed. We develop nonasymptotic, distribution-free upper confidence bounds for this quantity in two regimes: bounded alphabets (finite and known number of categories) and unbounded alphabets (countably infinite under a mild summability condition). We characterise the limits of data-independent worst-case bounds, showing that in the unbounded regime no nontrivial data-independent procedure can be uniformly valid. We then propose data-dependent bounds in both regimes and establish matching lower bounds demonstrating their near-optimality. We compare empirically the resulting procedures in both simulated and real datasets. Finally, we use these bounds to construct sequential stopping rules with finite-sample guarantees, and demonstrate robustness to contamination that introduces spurious low-prevalence categories.
January 29, 2026 at 7:33 PM
statme-bot.bsky.social
Alessandro Colombi, Mario Beraha, Amichai Painsky, Stefano Favaro: Confidence intervals for maximum unseen probabilities, with application to sequential sampling design https://arxiv.org/abs/2601.20320 https://arxiv.org/pdf/2601.20320 https://arxiv.org/html/2601.20320
January 29, 2026 at 6:53 AM
anaesjournal.bsky.social
It's always important to look at what interventions AREN'T recommended..

Here's a list of what interventions are NOT recommended for pain management after open thoracotomy.

Do you find any of these surprising?

#AnSky #MedSky #PainSky

doi.org/10.1111/anae...
January 27, 2026 at 5:00 PM
anaesjournal.bsky.social
Pain management after open thoracotomy 2025: procedure-specific postoperative pain management (PROSPECT) recommendations

#AnSky #PainSky #MedSky

doi.org/10.1111/anae...
January 27, 2026 at 4:00 PM
anaesjournal.bsky.social
After open thoracotomy adequate postoperative pain control is crucial for rehabilitation.

Recommendation: thoracic epidural analgesia or paravertebral blockade as a first-line intervention.

#AnSky #PainSky #MedSky

doi.org/10.1111/anae...
doi.org
January 27, 2026 at 3:28 PM
anaesjournal.bsky.social
First choice treatments to control pain after thoracotomy:
• thoracic epidural analgesia - delivers medicine near the spinal cord to block pain
• paravertebral blockade - numbs the nerves next to the spine that send pain signals from the chest

#AnSky #MedSky #PainSky

doi.org/10.1111/anae...
doi.org
January 20, 2026 at 4:09 PM
lincolnbohn.bsky.social
www.naatp.org/advocacy/pub...

Keep fighting! #AddictionSky #AddictionSci #PainSky #MedSky
Advocacy Causes Administration to Reverse Cuts
As we reported yesterday, the Administration had arbitrarily cut nearly two billion dollars from mental health and substance use disorder treatment programs that had been approved on a bi-partisan bas...
www.naatp.org
January 15, 2026 at 9:09 PM
anaesjournal.bsky.social
Chronic pain after day-case surgery: the next challenge in the prevention of chronic post-surgical pain

#PainSky #AnSky #MedSky

doi.org/10.1111/anae...
January 12, 2026 at 1:00 PM
rajlb.bsky.social
I have made a great medical discovery that many British healthcare professionals will be unaware of.

Whilst watching a US TV show, I bothered to look up what "Advil" was and it turns out it's ibuprofen.

Can I get this published?

#MedSky #PainSky #AnSky
January 11, 2026 at 5:15 PM
anaesjournal.bsky.social
Many patients are still in pain 3 months after their surgery.

Certain procedures have much higher rates of chronic pain after 3 months, including orthopaedic (35%), breast (15%) & gynaecological (11%).

#AnSky #PainSky

doi.org/10.1111/anae...
January 8, 2026 at 4:00 PM
anaesjournal.bsky.social
The estimated prevalence of chronic post-surgical pain was 7.2% - 1 in 14 patients!

It was associated with:
• week 1 pain scores
• orthopaedic, breast & plastic surgery
• non-surgical site chronic pain at baseline
• deprivation
• ethnicity

#AnSky #PainSky #SurgSky
doi.org
January 8, 2026 at 3:00 PM
anaesjournal.bsky.social
Welcome to POPPY - the first large UK multicentre, prospective observational study exploring chronic post-surgical pain after day-case surgery.

Read both papers here:
👉 doi.org/10.1111/anae...
👉 doi.org/10.1111/anae...

#AnSky #PainSky #MedSky
January 8, 2026 at 1:00 PM
anaesjournal.bsky.social
In the UK, over a third of patients presenting for day-case surgery are in pain.

One in four have access to opioid medications and a little over one in 10 are using opioids daily.

#AnSky #MedSky #SurgSky #PainSky

doi.org/10.1111/anae...
January 8, 2026 at 12:08 PM
anaesjournal.bsky.social
"Topping-up an epidural that has required more than two additional boluses of local anaesthetic in labour should, in our view, be avoided."

Do you agree? What is your practice?

#AnSky #ObsAnSky #PainSky
doi.org
January 7, 2026 at 1:00 PM
cslg-bot.bsky.social
Amichai Painsky: Who is the Winning Algorithm? Rank Aggregation for Comparative Studies https://arxiv.org/abs/2601.01664 https://arxiv.org/pdf/2601.01664 https://arxiv.org/html/2601.01664
January 6, 2026 at 6:34 AM
anaesthesiareports.bsky.social
Effect of intravenous lidocaine on nociception level-directed management in robot-assisted laparoscopic radical prostatectomy: protocol for a single-centre, factorial-randomised controlled trial (VALINOR study)

#AnSky #MedSky #PainSky
doi.org
November 28, 2025 at 4:24 PM
anaesjournal.bsky.social
High neuraxial block in obstetrics: are we only seeing the tip of the iceberg?

The presence of local anaesthetic in the epidural space makes the effect of subsequent intrathecal drug administration less predictable.

#AnSky #ObSky #PainSky

doi.org/10.1111/anae...
October 27, 2025 at 7:03 AM
anaesjournal.bsky.social
Erector spinae plane block vs. opioid-based regimen: a reply

#AnSky #RASky #PainSky

doi.org/10.1111/anae...
October 17, 2025 at 2:03 PM
anaesjournal.bsky.social
A systematic review of brain health in adults with chronic pain

#AnSky #MedSky #ICUSky #PainSky

doi.org/10.1111/anae...
A systematic review of brain health in adults with chronic pain
Introduction Recent research has linked chronic pain with an increased risk of clinical dementia diagnosis. Yet structural and functional brain changes associated with chronic pain and their…
doi.org
October 15, 2025 at 12:01 PM
anaesjournal.bsky.social
Esketamine infusion for the prevention of tourniquet-induced intra-operative hypertension

Esketamine:
⬇️ the RR of tourniquet-induced hypertension by 63%
⬇️ hypotension
• infusion of 0.25 mg kg-1 h-1 for the lower limb surgeries was well tolerated

#AnSky #RASky #PainSky

doi.org/10.1111/anae...
October 14, 2025 at 12:01 PM
anaesjournal.bsky.social
Pericapsular nerve group block for intracapsular vs. extracapsular hip fracture

#AnSky #RASky #PainSky
doi.org
October 14, 2025 at 11:10 AM
anaesjournal.bsky.social
How does the analgesic effect of the PENG block compare with the infra-inguinal fascia iliaca block in the emergency department?

#AnSky #RASky #PainSky

doi.org/10.1111/anae...
October 14, 2025 at 10:02 AM
anaesjournal.bsky.social
Beyond the block: optimising analgesic strategies in laparoscopic inguinal hernia repair

#AnSky #MedSky #PainSky #RASky

doi.org/10.1111/anae...
October 3, 2025 at 6:03 AM
anaesjournal.bsky.social
Methadone vs morphine for postop pain management following cardiac surgery

Patients allocated to the methadone group:
• had lower postop morphine requirements in the 24 h after extubation and for up to 72 h
• had longer time to first morphine rescue

#AnSky #PainSky

doi.org/10.1111/anae...
August 28, 2025 at 4:00 PM
anaesjournal.bsky.social
Is the incidence of chronic postsurgical pain after caesarean delivery truly low or do we still not know how to evaluate and report it adequately?

#AnSky #ObSky #PainSky

doi.org/10.1111/anae...
August 21, 2025 at 8:06 AM