🦵 Just published online in JPS❣️
"ATF4 Transcriptionally Activates NUPR1 to Promote Ferroptosis in Chondrocytes and Osteoarthritis Development"
-- Chen Kuang et al.
🔗 [https://doi.org/10.1016/j.jphyss.2025.100039]
#Osteoarthritis #Ferroptosis #ATF4 #NUPR1 #NowOnline #JPhysiolSci

Glutamine transporters regulate prostate cancer radiosensitivity through NUPR1-mediated stress response https://www.biorxiv.org/content/10.1101/2025.04.22.650063v1

Glutamine transporters regulate prostate cancer radiosensitivity through NUPR1-mediated stress response https://www.biorxiv.org/content/10.1101/2025.04.22.650063v1

The ferroptosis inhibitor NUPR1 coordinates the mitochondrial response to oxidative stress and cell metabolism during COPD pathogenesis in the lung https://www.biorxiv.org/content/10.1101/2025.04.27.650854v1

The ferroptosis inhibitor NUPR1 coordinates the mitochondrial response to oxidative stress and cell metabolism during COPD pathogenesis in the lung https://www.biorxiv.org/content/10.1101/2025.04.27.650854v1

Risico op kanker neemt af op hoge leeftijd

Na het 80ste levensjaar neemt het risico op kanker af. Door meer NUPR1 eiwit in de cellen, neemt de ijzerbeschikbaarheid in de cellen af www.voedingonline.nl/page/Nieuws/... #diëtisten #artsen #apothekers

I just stumbled upon this fascinating study - turns out cancer risk drops after 80, and scientists might have figured out why. It’s all about a protein called NUPR1. It slows cell regeneration in older age, limiting both healthy growth and cancer. This could change how we treat cancer and aging.

Higher levels of a protein called NUPR1 in older mice caused cells to act as if they were deficient in iron,
which in turn limited their regeneration rates
– putting restrictions on both healthy growth and cancerous tumors […]

: higher levels of a protein called NUPR1 in the older mice caused cells to act as if they were deficient in iron, which in turn limited their regeneration rates – putting restrictions on both healthy growth and cancerous tumors.

www.sciencealert.com/the-risk-of-...

EZH2 inhibition sensitizes MYC-high medulloblastoma cancers to PARP inhibition by regulating NUPR1-mediated DNA repair https://pubmed.ncbi.nlm.nih.gov/39562655/