There is currently no robust #clinicaltrial data confirming ruxolitinib's effectiveness for the complexity range of symptoms associated with #LongCOVID due to
- A significant concern with #JAKinhibitors is their immunosuppressive effect,
- A significant concern with #JAKinhibitors is their immunosuppressive effect,
October 19, 2025 at 5:44 AM
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#Medsky🧪 #IDsky #pharmasky #Publichealth This IPDMA of RCTs in adults admitted to 🏥 due to #COVID, #JAKinhibitors reduced mortality across all levels of respiratory support, independent of #dexamethasone or #tocilizumab & probably decreased serious & severe adverse events vs with no JAK inhibitors.
July 11, 2025 at 7:14 AM
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#MedSky🧪#IDSky #JAKinhibitors are used to treat #COVID19 because they can prevent phosphorylation of key proteins involved in the signal transduction that leads to immune activation and inflammation (e.g cellular response to proinflammatory cytokines such as IL6)
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
A specific phosphorylation-dependent conformational switch in SARS-CoV-2 nucleocapsid protein inhibits RNA binding
Phosphorylation of SARS-CoV-2 nucleocapsid protein induces conformational changes that inhibit RNA binding and release bound RNA.
www.science.org
August 6, 2024 at 8:33 PM
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📣 New in @drugsincontext.bsky.social
Upadacitinib for the treatment of radiographic axial spondyloarthritis — case series and review of the literature
Lopalco et al.
#drugsincontext #rheumatology #JAKinhibitors #pharmacology #MedSky #PharmSky
www.drugsincontext.com/upadacitinib...
Upadacitinib for the treatment of radiographic axial spondyloarthritis — case series and review of the literature
Lopalco et al.
#drugsincontext #rheumatology #JAKinhibitors #pharmacology #MedSky #PharmSky
www.drugsincontext.com/upadacitinib...
Upadacitinib for the treatment of radiographic axial spondyloarthritis — case series and review of the literature - Drugs in Context
Four case studies described here illustrate the effectiveness of upadacitinib in a range of real-world patients with axial spondyloarthritis.
www.drugsincontext.com
May 12, 2025 at 9:18 AM
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💊 JAK inhibitors for the treatment of palmoplantar pustulosis: a narrative review
Henriques dos Santos et al.
@drugsincontext.bsky.social #dermatology #JAKinhibitors #biologics #MedSky #PharmSky
www.drugsincontext.com/jak-inhibito...
Henriques dos Santos et al.
@drugsincontext.bsky.social #dermatology #JAKinhibitors #biologics #MedSky #PharmSky
www.drugsincontext.com/jak-inhibito...
JAK inhibitors for the treatment of palmoplantar pustulosis: a narrative review - Drugs in Context
This narrative review evaluates current evidence on the efficacy and safety of JAK inhibitors in the treatment of palmoplantar pustulosis.
www.drugsincontext.com
October 22, 2025 at 10:15 AM
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Researchers uncover the potential of JAK inhibitors to treat life-threatening skin disease 🔬🧬💉 www.news-medical.net/news/2024101... #JAKInhibitors #SkinDisease #Medical #Proteomics #DrugReactions #Biotech #Research #Inflammation @natureportfolio.bsky.social
Researchers uncover the potential of JAK inhibitors to treat life-threatening skin disease
Researchers identified Janus kinase inhibitors as a promising treatment for the severe drug-induced skin condition toxic epidermal necrolysis, by analyzing patient biopsies with deep visual proteomics...
www.news-medical.net
October 18, 2024 at 3:31 AM
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#MedSky #IDSky #COVID19 #DrugDevelopment
NEW A loss-of-function variant in PTPN2 assoc w/ #autoimmune disease incl #IBD can ⬆️ expression of ACE2 receptor via ⬆️ JAK-STAT signaling, making cells more prone to #SARSCoV2 invasion. Reversible w/ JAK inhibition.
www.sciencedirect.com/science/arti...
NEW A loss-of-function variant in PTPN2 assoc w/ #autoimmune disease incl #IBD can ⬆️ expression of ACE2 receptor via ⬆️ JAK-STAT signaling, making cells more prone to #SARSCoV2 invasion. Reversible w/ JAK inhibition.
www.sciencedirect.com/science/arti...
Tofacitinib Mitigates the Increased SARS-CoV-2 Infection Susceptibility Caused by an IBD Risk Variant in the PTPN2 Gene
Coronavirus disease (COVID-19), caused by SARS-CoV-2, triggered a global pandemic with severe medical and socioeconomic consequences. While fatality r…
www.sciencedirect.com
January 15, 2025 at 2:28 PM
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In a recent episode of the Evidence Based Hair Podcast, I discussed the safety of JAK inhibitors in pregnancy. m.youtube.com/watch?v=-Zap... #alopeciaareata #jakinhibitors #ritlecitinib #baricitinib #tofacitinib
Season 8 Episode 1 Navigating JAK Inhibitors and Pregnancy: Insights and Implications
YouTube video by Donovan Medical
m.youtube.com
November 22, 2024 at 9:37 PM
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#AlopeciaAreata #HairLossTreatment #Dermatology #JAKInhibitors #SkinCareNetwork #HairRestoration #MedicalDermatology
October 24, 2025 at 7:03 AM
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Several #JAKinhibitors are available for clinical use, but only #baricitinib & #tofacitinib have been studied for the treatment of #COVID19.
www.covid19treatmentguidelines.nih.gov/therapies/im...
www.covid19treatmentguidelines.nih.gov/therapies/im...
Janus Kinase Inhibitors | COVID-19 Treatment Guidelines
Review information on the use of Janus kinase inhibitors for the treatment of COVID-19.
www.covid19treatmentguidelines.nih.gov
August 6, 2024 at 8:36 PM
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