🎉 🎉 Congratulations to all the authors on this well-deserved recognition, specially Diego García Jiménez as a SEQT member presenting the work!
🔗 Read the full article here: doi.org/10.1021/acs.jm…#MedCheme#Bioavailabilityt#Chameleonicityt#zelenana
🔗 Read the full article here: doi.org/10.1021/acs.jm…#MedCheme#Bioavailabilityt#Chameleonicityt#zelenana
https://doi.org/10.1021/acs.jm…
April 3, 2025 at 6:55 PM
🎉 🎉 Congratulations to all the authors on this well-deserved recognition, specially Diego García Jiménez as a SEQT member presenting the work!
🔗 Read the full article here: doi.org/10.1021/acs.jm…#MedCheme#Bioavailabilityt#Chameleonicityt#zelenana
🔗 Read the full article here: doi.org/10.1021/acs.jm…#MedCheme#Bioavailabilityt#Chameleonicityt#zelenana
📢 Best Publication Award 🏆
We are pleased to announce that the “Chamelogk: A Chromatographic Chameleonicity Quantifier to Design Orally Bioavailable Beyond-Rule-of‐5 Drugs” has been selected as the best publication in the 2ndEdition of the #SEQT_articles initiative.
We are pleased to announce that the “Chamelogk: A Chromatographic Chameleonicity Quantifier to Design Orally Bioavailable Beyond-Rule-of‐5 Drugs” has been selected as the best publication in the 2ndEdition of the #SEQT_articles initiative.
April 3, 2025 at 6:55 PM
📢 Best Publication Award 🏆
We are pleased to announce that the “Chamelogk: A Chromatographic Chameleonicity Quantifier to Design Orally Bioavailable Beyond-Rule-of‐5 Drugs” has been selected as the best publication in the 2ndEdition of the #SEQT_articles initiative.
We are pleased to announce that the “Chamelogk: A Chromatographic Chameleonicity Quantifier to Design Orally Bioavailable Beyond-Rule-of‐5 Drugs” has been selected as the best publication in the 2ndEdition of the #SEQT_articles initiative.
We integrated in the linker ferrocene—an organometallic structure with freely rotating cyclopentadienyl rings around a sandwiched iron metal ion. This unique “molecular hinge” introduces dynamic flexibility and chameleonicity to PROTACs. ⚙️✨ 2/5
December 21, 2024 at 11:42 PM
We integrated in the linker ferrocene—an organometallic structure with freely rotating cyclopentadienyl rings around a sandwiched iron metal ion. This unique “molecular hinge” introduces dynamic flexibility and chameleonicity to PROTACs. ⚙️✨ 2/5
Some new bRo5 stuff from AbbVie. Here they make an argument for EPSA/TPSA as a measure of chameleonicity.
Beyond Rule of Five and PROTACs in Modern Drug Discovery: Polarity Reducers, Chameleonicity, and the Evolving Physicochemical Landscape
Developing orally bioavailable drugs demands an understanding of absorption in early drug development. Traditional methods and physicochemical properties optimize absorption for rule of five (Ro5) com...
pubs.acs.org
March 19, 2024 at 11:19 PM
Some new bRo5 stuff from AbbVie. Here they make an argument for EPSA/TPSA as a measure of chameleonicity.
Very nice review from Jan Kihlberg’s group on molecular chameleonicity and techniques to interrogate it.
Molecular chameleons in drug discovery - Nature Reviews Chemistry
Molecular chameleons adapt their conformations to the properties of the environment so that polar functionalities are dynamically shielded or exposed. This allows chameleons to display both high cell ...
www.nature.com
February 12, 2024 at 12:52 PM
Very nice review from Jan Kihlberg’s group on molecular chameleonicity and techniques to interrogate it.