#CellStemCell
Early results from our Luxa Biotech-sponsored and #NEIfunded #ClinicalTrial are out in #CellStemCell. The trial uses an adult RPE stem cell therapy for dry age-related #MacularDegeneration.

Beautiful cover art by Dr. Yangzi Isabel Tian.

Full Text | zurl.co/gQ2bq
@cellpress.bsky.social
#NIHfunded
November 7, 2025 at 3:53 AM
Our new paper in Cell Stem Cell introduces human heart–macrophage assembloids — the first, highly sophisticated organoid model of immune–cardiac interactions.

#NAMs #Organoids #CardiacResearch #CellStemCell #AFib #NIH #MSU

Link to the paper: www.cell.com/cell-stem-ce...
Human heart-macrophage assembloids mimic immune-cardiac interactions and enable arrhythmia disease modeling
O’Hern et al. present a novel human heart-macrophage assembloid platform generated by integrating hPSC-derived embryonic monocytes into heart organoids. These tissue-resident macrophages regulate card...
www.cell.com
October 27, 2025 at 6:29 PM
🧠✨My new cover for @CellStemCell!

My artwork for the paper illustrates an #organ_chip model of the human #spinal_cord designed to study #amyotrophic_lateral_sclerosis (ALS), neurodegenerative disorder with no cure that causes the loss of motor neurons controlling voluntary movement.
October 5, 2025 at 10:45 AM
#TissueEngineeredBloodVessel

Decellularized 👤umbilical cord artery
Seeded: #hiPSC #EndothelialCell
Bioreactor trained: pulsatile unidirec flow 15➡️5 dyn/cm2

Rat #InferiorVenaCava graft▶️
0️⃣Thrombosis
Complete repop by host EC 2 wk SMC 2 mo

#CellStemCell 2025
www.sciencedirect.com/science/arti...
October 1, 2025 at 7:56 PM
@rohanpaul_ai https://x.com/rohanpaul_ai/status/1941227610475831617 #x-rohanpaul_ai

Quote: https://x.com/CellStemCell/status/1940885399012102270

📢 Big anit-aging research just came out.

A single molecule jolts aged muscles back into repair mode.

Old muscles heal like young after...
July 4, 2025 at 8:30 PM
New #CellStemCell paper from Helen Blau and colleagues: Multiomic profiling reveals that prostaglandin E2 reverses aged muscle stem cell dysfunction, leading to increased regeneration and strength. #Myoblue tinyurl.com/yvf4cdch
Multiomic profiling reveals that prostaglandin E2 reverses aged muscle stem cell dysfunction, leading to increased regeneration and strength
Wang et al. uncover that aged muscle stem cells have blunted PGE2-EP4 signaling that is critical for their regenerative function. Treatment with exogenous PGE2 reverses age-related defects in muscle s...
tinyurl.com
June 12, 2025 at 4:10 PM
Scientists program stem cells to mimic first days of embryonic development
L: https://news.ucsc.edu/2025/03/shariati-cellstemcell-25.html
C: https://news.ycombinator.com/item?id=43431057
posted on 2025.03.20 at 21:45:19 (c=3, p=6)
March 23, 2025 at 11:09 AM
Beyond excited to say my first PhD paper is out today in @CellStemCell 📷. Here, we explored the role of epigenetic heterogeneity on malignant expansion, using a new approach called STRACK
www.cell.com/cell-stem-ce...
Pre-existing stem cell heterogeneity dictates clonal responses to the acquisition of leukemic driver mutations
Singh, Fernandez-Perez, et al. use hematopoietic stem cell barcoding to study clones with and without activation of cancer driver mutations, identifying that pre-existing stem cell states can dictate ...
www.cell.com
February 27, 2025 at 1:48 AM
🧬 BREAKTHROUGH: Scientists leap forward with bi-paternal offspring!🐭 Surviving to adulthood, this genetic advance could reshape research & medicine overcoming developmental challenges. 🚀 #Science #Genetics #CellStemCell #trends #PhDlife #innovation #ScienceBreakthrough

www.cell.com/cell-stem-ce...
Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals
Li and colleagues successfully generated bi-paternal mice that developed to adulthood by targeting 20 key imprinted loci. This study underscores imprinting gene abnormalities as the primary barrier to...
www.cell.com
February 8, 2025 at 8:26 AM
🎉 Happy New Year from #DrawImpacts Studio! 🎨
We’re thrilled to kick off 2025 with exciting news: our first cover of the year has been selected for #CellStemCell 's first issue of 2025!! To another year of impactful collaborations, science, and creativity—we can’t wait to see what this year brings! 🌟
January 2, 2025 at 8:06 PM
Delighted to have our work led by #RichardVoit
from our group featured on the cover of #CellStemCell
today. Artwork by the amazing
@drawimpacts.bsky.social:

www.cell.com/cell-stem-ce...

Stay tuned as we work on initiating a clinical trial for this approach!
January 2, 2025 at 4:01 PM
#SpatialTranscriptomics #Visium
Human Healthy Skin Wound Healing (This is a Human Trial!🥸 N=7)
D0/1/7/30

Angiogenic niche comprising #EndothelialCell Fibroblast Mφ

Mφ secretome
D1 (inflam) IL1A/B CCL7
D7 (prolif) TGFB C1QB
D30 (remodeling) IGF1 C1QB

#CellStemCell 2024
www.cell.com/cell-stem-ce...
December 27, 2024 at 12:09 PM
hiPSC-derived venous #EndothelialCell #iVEC

Mesoderm progenitors+VEGFA+FGF2+RA+DAPT

MEF2C as a putative venous endothelial TF

Retain EphB4 venous marker in vivo

Modeling TIE2L914F #VenousMalformation
DRUG-seq #DeepLearning➡️Bosutinib

#CellStemCell 2024
www.sciencedirect.com/science/arti...
December 24, 2024 at 1:07 PM
#WeekendRead! #MomIsAlwaysMom! Dang, Kundu &co show @ CellStemCell that maternal #microbiota imprints the neural and intestinal stem cell compartments of their offsprings via mTOR signaling, leading to long lasting reprogramming of brain & gut functions! Doi.org/10.1016/j.stem.2024.10.003
Redirecting
Doi.org
December 14, 2024 at 4:35 PM
Chronic autoimmunity rewires metabolism in progenitors, correlating with innate immune memory formation in macrophages that increases antibacterial activity but might also aggravate autoimmune diseases?
shorturl.at/SZ1Ww

#CellStemCell
November 15, 2024 at 10:46 PM
First post on this platform!
Check out our review on"
"Early human development and stem cell-based human embryo models"
@CellStemCell
www.cell.com/cell-stem-ce...
Early human development and stem cell-based human embryo models
Stem cell-based models of the human embryo promise to transform the study of human embryogenesis. In this review, we discuss our current knowledge of the first 2 weeks of human embryo development and ...
www.cell.com
November 11, 2024 at 9:52 PM
MedSky🧪#IDSky #Publichealth #Neuroimmunology #NeuroCovid #LongCovid Monitor #COVID19 patients for Parkinson’s symptoms, scientists say . The Virus infects dopaminergic neurons in brain, study finds, stopping cell division… @CellStemCell

www.cell.com/cell-stem-ce... www.cell.com/cms/attachme...
February 7, 2024 at 4:47 PM
🔬 Exciting Update! 🌐 Thrilled for #CSOrganoids2024 with speakers like @JimWellsLab from @CincyChildrens – a standout from last year's✨ #ASCBcourse #ScienceConference #stemcell #organoids @LabExRevive @PasteurEdu

x.com/CellStemCell/s…
February 10, 2025 at 5:56 PM
Study findings, 'published in @CellStemCell on 17 Jan 2024, show that dopamine neurons infected with #SARSCoV2 stop working and send out chemical signals that cause inflammation.' @WeillCornell @ChenShuibing @WCMSurgery @ScienceDaily
www.sciencedaily.com/releases/202...
SARS-CoV-2 can infect dopamine neurons causing senescence
A new study reported that SARS-CoV-2, the virus that causes COVID, can infect dopamine neurons in the brain and trigger senescence -- when a cell loses the ability to grow and divide. The researchers ...
www.sciencedaily.com
January 21, 2024 at 9:50 PM
MedSky🧪#IDSky #NeuroCovid Do we have an explanation for #COVID19 #brainfog and lethargy? Study in @CellStemCell shows the #SARSCoV2 virus triggers #senescence when it infects dopamine neurons; the neurons stop working, inflammation ensues. @BuckInstitute

www.cell.com/cell-stem-ce...
January 21, 2024 at 4:33 AM
Our Preview on cervical organoids in @CellStemCell is out!
This was fun to write, and only possible thanks to @SaraSartini26 who got us through to the finish line in record time

https://authors.elsevier.com/a/1dX3j6tu0CeS~l#.YQwKDcsq81Q.twitter
ScienceDirect
authors.elsevier.com
November 26, 2024 at 8:43 PM
The study is the result of a great synergy between two research groups at the IBMB-CSIC combining their knowledge in Developmental and Structural Biology.
In addition to having technical assistance at the IBMB facility @IbmbMip https://twitter.com/CellStemCell/status/1323652389803622403
November 18, 2024 at 8:08 AM
Really thankful to @CellStemCell for amplifying the voices of early career scientists, honored to be included! https://www.sciencedirect.com/science/article/pii/S1934590920304628?via%3Dihub
ScienceDirect
www.sciencedirect.com
November 27, 2024 at 3:02 AM
New study in @CellStemCell suggests elevated Myc drives many of the phenotypes of #FanconiAnemia in bone marrow and cancer
https://www.sciencedirect.com/science/article/pii/S1934590920304501
November 23, 2024 at 10:45 AM