CD47 inhibits #phagocytosis through Vav dephosphorylation, say Wyatt Miller, Meghan Morrissey (@mmorrissey.bsky.social) and colleagues @ucsantabarbara.bsky.social: rupress.org/jcb/article/...
#Immunology #CellSignaling
#Immunology #CellSignaling
October 23, 2025 at 8:03 PM
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New work @jcb.org from Guanhua Bai, Hao Li, Mingjie Zhang and colleagues reveals an unexpected function of IQSEC2 as a scaffold protein and thus explains why IQSEC2 can bidirectionally regulate synaptic strengths. rupress.org/jcb/article/...
#Biochemistry #Neuroscience #CellSignaling
#Biochemistry #Neuroscience #CellSignaling
October 22, 2025 at 6:15 PM
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New work from Guanhua Bai, Hao Li, Mingjie Zhang and colleagues reveals an unexpected function of IQSEC2 as a scaffold protein and thus explains why IQSEC2 can bidirectionally regulate synaptic strengths. rupress.org/jcb/article/...
#Biochemistry #Neuroscience #CellSignaling
#Biochemistry #Neuroscience #CellSignaling
October 22, 2025 at 4:45 PM
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Immerse yourself in possibility at #ASBMB26!
Explore new ideas, present discoveries that expand our understanding & help shape the future of molecular life sciences.
• Regular deadline: Nov. 17.
• Submit your abstract: www.asbmb.org/annual-meeti....
#MakeItPossible #AI #AgingResearch #CellSignaling
Explore new ideas, present discoveries that expand our understanding & help shape the future of molecular life sciences.
• Regular deadline: Nov. 17.
• Submit your abstract: www.asbmb.org/annual-meeti....
#MakeItPossible #AI #AgingResearch #CellSignaling
October 14, 2025 at 9:50 PM
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#Nanomedicine #GPCR #PainResearch #DrugDelivery #PAR2 #CellSignaling @pazduran.bsky.social @karapedsgastrodoc.bsky.social @margolislabnyu.bsky.social @tonelloraquel.bsky.social
October 13, 2025 at 5:53 PM
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PhD — cellular signaling in photosymbiosis
Deadline: Nov 5
Apply 👉 recruitingapp-5442.de.umantis.com/Vacancies/20...
#PhDposition #CellSignaling #Symbiosis
Deadline: Nov 5
Apply 👉 recruitingapp-5442.de.umantis.com/Vacancies/20...
#PhDposition #CellSignaling #Symbiosis
PhD position in cellular signaling in photosymbiosis (f/d/m)
Layout AWI HIPP extern, englisch
recruitingapp-5442.de.umantis.com
October 6, 2025 at 12:34 PM
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Reprogrammed #metabolism + protein sugar modification = #cancer advantage. Targeting O-GlcNAcylation on EGFR & GLUT1 destabilizes their function in #BreastCancer cells. #CancerBiology #CellSignaling doi.org/10.1139/bcb-...
Canadian Science Publishing
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doi.org
September 17, 2025 at 1:27 PM
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The tyrosine #phosphatase PTPN22 functions as a scaffold protein to maintain mTORC2 complex integrity and function, independent of its phosphatase activity.
#cellsignaling
-> www.embopress.org/doi/full/10....
#cellsignaling
-> www.embopress.org/doi/full/10....
September 16, 2025 at 2:57 PM
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Reprogrammed #metabolism + protein sugar modification = #cancer advantage. Targeting O-GlcNAcylation on EGFR & GLUT1 destabilizes their function in #BreastCancer cells. #CancerBiology #CellSignaling
O-GlcNAcylation of epidermal growth factor receptor and glucose transporter 1 prevents their intrinsic down regulation in breast cancer cells
The hexosamine biosynthetic pathway (HBP) is upregulated in many cancer cell types leading to upregulation of post-translational modification of proteins by β-N-acetylglucosamine (O-GlcNAc), the…
ow.ly
September 12, 2025 at 1:26 PM
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ATG conjugation dependent/independent mechanisms underlie lysosomal stress induced TFEB regulation, say Shiori Akayama, Takayuki Shima, Shuhei Nakamura and colleagues (Nara Medical University): rupress.org/jcb/article/...
#CellSignaling #Lysosomes #autophagy
#CellSignaling #Lysosomes #autophagy
September 5, 2025 at 8:15 PM
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Submembrane liprin-α1 clusters spatially localize #insulin granule fusion, say Kylie Deng, Peter Thorn and colleagues @sydney.edu.au: rupress.org/jcb/article/...
#CellSignaling #Physiology
#CellSignaling #Physiology
September 4, 2025 at 2:30 PM
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In @jcb.org Deng, Thorn et al. @sydney.edu.au report that liprin-α1 is part of a glucose-regulated complex controlling the positioning of #insulin granule fusion, revealing a novel step in the mechanism of stimulus–secretion coupling. rupress.org/jcb/article/...
#CellSignaling #Physiology
#CellSignaling #Physiology
August 28, 2025 at 4:15 PM
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Deng, Thorn et al. @sydney.edu.au report that liprin-α1 is part of a glucose-regulated complex controlling the positioning of #insulin granule fusion, revealing a novel step in the mechanism of stimulus–secretion coupling. rupress.org/jcb/article/...
#CellSignaling #Physiology
#CellSignaling #Physiology
August 28, 2025 at 4:01 PM
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Identification of organelle-specific #autophagy regulators from tandem #CRISPR screens. New study from Truc Losier, Karyn King, Maxime Rousseaux, and Ryan Russell (@russellbiolab.bsky.social) @uottawa.ca: rupress.org/jcb/article/...
#Biochemistry #CellSignaling
#Biochemistry #CellSignaling
August 28, 2025 at 1:45 PM
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✨Cells whisper with gas signals—nitric oxide & ammonia!—but controlling these fleeting messengers is a tricky, vital quest. 🤯 #CellSignaling
Source: https://phys.org/news/2025-08-bioelectrosynthesis-platform-enables-precision-cell.html
Source: https://phys.org/news/2025-08-bioelectrosynthesis-platform-enables-precision-cell.html
Bioelectrosynthesis platform enables switch-like, precision control of cell signaling
Cells use various signaling molecules to regulate the nervous, immune, and vascular systems. Among these, nitric oxide (NO) and ammonia (NH₃) play important roles, but their chemical instability and gaseous nature make them difficult to generate or control externally.
phys.org
August 17, 2025 at 2:51 AM
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📣 Online now - the Feature Review "LRRC8/VRAC chloride and metabolite channels in signaling and volume regulation" from Thomas Jentsch et al.
#VolumeRegulatedAnionChannel #VRAC #SWELL1 #Transporter #CellSignaling
Read it here: authors.elsevier.com/sd/article/S...
#VolumeRegulatedAnionChannel #VRAC #SWELL1 #Transporter #CellSignaling
Read it here: authors.elsevier.com/sd/article/S...
August 6, 2025 at 3:32 PM
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STIM-IP3R crosstalk regulates migration of #BreastCancer cells. New study from Ruslana Militsin, Raz Palty and colleagues @TechnionLive: rupress.org/jcb/article/...
#CellSignaling #Biophysics #Migration #motility #Cancer
#CellSignaling #Biophysics #Migration #motility #Cancer
August 4, 2025 at 1:45 PM
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Myosin 15 participates in assembly and remodeling of the presynapse, say Astrid Petzoldt and colleagues @freieuniversitaet.bsky.social @fmp-berlin.de: rupress.org/jcb/article/...
#Neuroscience #CellSignaling
#Neuroscience #CellSignaling
July 15, 2025 at 3:16 PM
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This #MostRead review describes the functions of PI3K #SignalingPathways, how PIK3CA mutations rewire #CellSignaling, metabolism, & the #TumorMicroenvironment, & discusses therapeutic strategies for PIK3CA-mutant tumors. @cwrufarm.bsky.social #medsky
#OpenAccess:
#OpenAccess:
www.sciencedirect.com
July 10, 2025 at 12:56 PM
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Astrid Petzoldt et al. @freieuniversitaet.bsky.social @fmp-berlin.de identify the conserved unconventional class XV myosin, Myo15, an actin motor, as a novel regulator of presynaptic assembly and remodeling in #Drosophila. rupress.org/jcb/article/...
#Neuroscience #CellSignaling
#Neuroscience #CellSignaling
July 8, 2025 at 5:45 PM
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In @jcb.org, Astrid Petzoldt et al. @freieuniversitaet.bsky.social @fmp-berlin.de identify the conserved unconventional class XV myosin, Myo15, an actin motor, as a novel regulator of presynaptic assembly and remodeling in #Drosophila. rupress.org/jcb/article/...
#Neuroscience #CellSignaling
#Neuroscience #CellSignaling
July 8, 2025 at 5:45 PM
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The PAX3-FOXO1 fusion gene reduces cell-ECM interactions and TGFβ signaling in rhabdomyosarcoma, say Antonios Chronopoulos, Ivan Chavez, Chandra Vemula, JinSeok Park and colleagues (Children’s Hospital Los Angeles @keck.usc.edu) rupress.org/jcb/article/...
#Adhesion #Cancer #CellSignaling
#Adhesion #Cancer #CellSignaling
July 7, 2025 at 2:38 PM
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A substrate-interacting region of Parkin directs ubiquitination of the mitochondrial GTPase Miro1, say Joanna Koszela, Helen Walden (@hw1o9.bsky.social) and colleagues @uofglasgow.bsky.social: rupress.org/jcb/article/...
#CellSignaling #Biochemistry
#CellSignaling #Biochemistry
July 4, 2025 at 1:23 PM
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In @jcb.org, Chronopoulos, Chavez, Vemula, Park et al. @keck.usc.edu show that the PAX3-FOXO1 fusion gene suppresses TGFβ signaling and cell–ECM interactions by stimulating nitric oxide synthesis in fusion-positive rhabdomyosarcoma. rupress.org/jcb/article/...
#Adhesion #Cancer #CellSignaling
#Adhesion #Cancer #CellSignaling
July 1, 2025 at 2:54 PM
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