Even in the shorter term phase 2 data the average triglyceride reduction was 40% on retatrutide. Lilly did a deeper dive on that data and found retatrutide down regulates ApoC3 and ANGPTL3/8 both of which are critical factors for triglyceride levels.
September 16, 2025 at 6:12 PM
Even in the shorter term phase 2 data the average triglyceride reduction was 40% on retatrutide. Lilly did a deeper dive on that data and found retatrutide down regulates ApoC3 and ANGPTL3/8 both of which are critical factors for triglyceride levels.
August 5, 2025 at 8:02 PM
We're 3 weeks out and are so excited to share the blurb for Malice!
I know how this story goes. There’s no such thing as happily ever after for the four horsemen. Merri was never ours to keep.
preorder books2read.com/apoc3
Start The Mate Games: Apocalypse books2read.com/apoc1
I know how this story goes. There’s no such thing as happily ever after for the four horsemen. Merri was never ours to keep.
preorder books2read.com/apoc3
Start The Mate Games: Apocalypse books2read.com/apoc1
July 21, 2025 at 5:14 PM
We're 3 weeks out and are so excited to share the blurb for Malice!
I know how this story goes. There’s no such thing as happily ever after for the four horsemen. Merri was never ours to keep.
preorder books2read.com/apoc3
Start The Mate Games: Apocalypse books2read.com/apoc1
I know how this story goes. There’s no such thing as happily ever after for the four horsemen. Merri was never ours to keep.
preorder books2read.com/apoc3
Start The Mate Games: Apocalypse books2read.com/apoc1
In another home-run for genetics-enabled drug development, APOC3 inhibition is approved to treat a disease of hypertriglyceridemia.
👇
www.science.org/doi/10.1126/....
Human genetics identified the target in 2008, thanks to work done in the Amish population.
👇
www.nature.com/articles/s41...
👇
www.science.org/doi/10.1126/....
Human genetics identified the target in 2008, thanks to work done in the Amish population.
👇
www.nature.com/articles/s41...
A Null Mutation in Human APOC3 Confers a Favorable Plasma Lipid Profile and Apparent Cardioprotection
Apolipoprotein C-III (apoC-III) inhibits triglyceride hydrolysis and has been implicated in coronary artery disease. Through a genome-wide association study, we have found that about 5% of the Lancast...
www.science.org
January 21, 2025 at 12:14 AM
In another home-run for genetics-enabled drug development, APOC3 inhibition is approved to treat a disease of hypertriglyceridemia.
👇
www.science.org/doi/10.1126/....
Human genetics identified the target in 2008, thanks to work done in the Amish population.
👇
www.nature.com/articles/s41...
👇
www.science.org/doi/10.1126/....
Human genetics identified the target in 2008, thanks to work done in the Amish population.
👇
www.nature.com/articles/s41...
Rona gets FDA go-ahead for Phase 2 siRNA heart disease trial
Company to initiate clinical study of gene-silencing drug targeting hypertriglyceridemia via a reduction in APOC3 protein expression.
#longevity #biotech #RNA #heartdisease
Company to initiate clinical study of gene-silencing drug targeting hypertriglyceridemia via a reduction in APOC3 protein expression.
#longevity #biotech #RNA #heartdisease
Rona gets FDA go-ahead for Phase 2 siRNA heart disease trial
Company to initiate clinical study of gene-silencing drug targeting hypertriglyceridemia via a reduction in APOC3 protein expression.
longevity.technology
March 19, 2025 at 6:06 PM
Rona gets FDA go-ahead for Phase 2 siRNA heart disease trial
Company to initiate clinical study of gene-silencing drug targeting hypertriglyceridemia via a reduction in APOC3 protein expression.
#longevity #biotech #RNA #heartdisease
Company to initiate clinical study of gene-silencing drug targeting hypertriglyceridemia via a reduction in APOC3 protein expression.
#longevity #biotech #RNA #heartdisease
July 28, 2025 at 5:04 PM
August 5, 2025 at 8:00 PM
August 13, 2025 at 3:01 PM
Are you ready for Malice? He's an angsty mfer.
Coming August 11
preorder books2read.com/apoc3
Start The Mate Games: Apocalypse books2read.com/apoc1
Coming August 11
preorder books2read.com/apoc3
Start The Mate Games: Apocalypse books2read.com/apoc1
July 23, 2025 at 3:00 PM
Are you ready for Malice? He's an angsty mfer.
Coming August 11
preorder books2read.com/apoc3
Start The Mate Games: Apocalypse books2read.com/apoc1
Coming August 11
preorder books2read.com/apoc3
Start The Mate Games: Apocalypse books2read.com/apoc1
“If you want to leave this room alive, you will tell me everything there is to know about one Meredith Deveraux.”
📖 books2read.com/apoc3
🎧 bit.ly/40Gv9hc
📖 books2read.com/apoc3
🎧 bit.ly/40Gv9hc
August 12, 2025 at 1:00 PM
“If you want to leave this room alive, you will tell me everything there is to know about one Meredith Deveraux.”
📖 books2read.com/apoc3
🎧 bit.ly/40Gv9hc
📖 books2read.com/apoc3
🎧 bit.ly/40Gv9hc
Up next metabolic markers and RAAS system: insulin, C-peptide, renin, angiotensinogen, and aldosterone
Calcium, phosphate, parathyroid hormone, vitamin D, ApoB, APoC3, NT-BNP,
Also "serum large-scale proteomic analysis will be performed to assess changes in protein metabolism"
Almost done!
Calcium, phosphate, parathyroid hormone, vitamin D, ApoB, APoC3, NT-BNP,
Also "serum large-scale proteomic analysis will be performed to assess changes in protein metabolism"
Almost done!
October 30, 2025 at 11:26 PM
Up next metabolic markers and RAAS system: insulin, C-peptide, renin, angiotensinogen, and aldosterone
Calcium, phosphate, parathyroid hormone, vitamin D, ApoB, APoC3, NT-BNP,
Also "serum large-scale proteomic analysis will be performed to assess changes in protein metabolism"
Almost done!
Calcium, phosphate, parathyroid hormone, vitamin D, ApoB, APoC3, NT-BNP,
Also "serum large-scale proteomic analysis will be performed to assess changes in protein metabolism"
Almost done!
"Bring on the dream smut. I. AM. HERE. FOR. IT!!!" ⭐ ⭐ ⭐ ⭐ ⭐ - Amy V.
📖 books2read.com/apoc3
🎧 bit.ly/40Gv9hc
📖 books2read.com/apoc3
🎧 bit.ly/40Gv9hc
August 8, 2025 at 8:00 PM
"Bring on the dream smut. I. AM. HERE. FOR. IT!!!" ⭐ ⭐ ⭐ ⭐ ⭐ - Amy V.
📖 books2read.com/apoc3
🎧 bit.ly/40Gv9hc
📖 books2read.com/apoc3
🎧 bit.ly/40Gv9hc
【Plozasiranで高TG血症例のLDL粒子径大型化？/ JACC】
米国、重度高TG血症/複合型脂質異常症403例観察：
肝apoC3発現抑制剤plozasiran２回皮下注でプラセボに比べ、
・LDL粒子数に差はないものの、大径、中等径LDL粒子数が46〜88%
増加。
x.gd/Xnh1y
米国、重度高TG血症/複合型脂質異常症403例観察：
肝apoC3発現抑制剤plozasiran２回皮下注でプラセボに比べ、
・LDL粒子数に差はないものの、大径、中等径LDL粒子数が46〜88%
増加。
x.gd/Xnh1y
Effect of Targeting apoC-III with Plozasiran on Lipoprotein Particle Size and Number in Hypertriglyceridemia
Plozasiran, an investigational siRNA targeting hepatic apoC-III, reduces triglyceride-rich lipoproteins (TRLs). The impact of plozasiran on lipoprotei…
x.gd
March 18, 2025 at 11:17 PM
【Plozasiranで高TG血症例のLDL粒子径大型化？/ JACC】
米国、重度高TG血症/複合型脂質異常症403例観察：
肝apoC3発現抑制剤plozasiran２回皮下注でプラセボに比べ、
・LDL粒子数に差はないものの、大径、中等径LDL粒子数が46〜88%
増加。
x.gd/Xnh1y
米国、重度高TG血症/複合型脂質異常症403例観察：
肝apoC3発現抑制剤plozasiran２回皮下注でプラセボに比べ、
・LDL粒子数に差はないものの、大径、中等径LDL粒子数が46〜88%
増加。
x.gd/Xnh1y
August 10, 2025 at 8:02 PM
Effects of HA1 (a Probucol Analogue) and ApoC3 siRNA on Lipoprotein-Amyloid Metabolism, Neurovascular Integrity and Cognitive Function in db/db Mice https://www.biorxiv.org/content/10.1101/2024.11.05.622070v1
Effects of HA1 (a Probucol Analogue) and ApoC3 siRNA on Lipoprotein-Amyloid Metabolism, Neurovascular Integrity and Cognitive Function in db/db Mice https://www.biorxiv.org/content/10.1101/2024.11.05.622070v1
Abstract Background and aims Chronically elevated levels of circulating lipoprotein-amyloid-beta (Ab
www.biorxiv.org
November 6, 2024 at 5:16 AM
Effects of HA1 (a Probucol Analogue) and ApoC3 siRNA on Lipoprotein-Amyloid Metabolism, Neurovascular Integrity and Cognitive Function in db/db Mice https://www.biorxiv.org/content/10.1101/2024.11.05.622070v1
August 12, 2025 at 8:00 PM
📣 𝗛𝗲'𝘀 𝗵𝗲𝗿𝗲! 𝗠𝗮𝗹𝗶𝗰𝗲 𝗶𝘀 𝗟𝗜𝗩𝗘 𝗮𝗻𝗱 𝗵𝗲'𝘀 𝗮𝘃𝗮𝗶𝗹𝗮𝗯𝗹𝗲 𝗼𝗻 𝗲-𝗯𝗼𝗼𝗸, 𝗮𝘂𝗱𝗶𝗼, 𝗮𝗻𝗱 𝗽𝗿𝗶𝗻𝘁! 🎊
📖 books2read.com/apoc3
🎧 bit.ly/40Gv9hc
📖 books2read.com/apoc3
🎧 bit.ly/40Gv9hc
August 11, 2025 at 1:00 PM
📣 𝗛𝗲'𝘀 𝗵𝗲𝗿𝗲! 𝗠𝗮𝗹𝗶𝗰𝗲 𝗶𝘀 𝗟𝗜𝗩𝗘 𝗮𝗻𝗱 𝗵𝗲'𝘀 𝗮𝘃𝗮𝗶𝗹𝗮𝗯𝗹𝗲 𝗼𝗻 𝗲-𝗯𝗼𝗼𝗸, 𝗮𝘂𝗱𝗶𝗼, 𝗮𝗻𝗱 𝗽𝗿𝗶𝗻𝘁! 🎊
📖 books2read.com/apoc3
🎧 bit.ly/40Gv9hc
📖 books2read.com/apoc3
🎧 bit.ly/40Gv9hc
James Joseph and Stella Hunter have a very important message for you (Part 1)
📖 books2read.com/apoc3
🎧 bit.ly/40Gv9hc
📖 books2read.com/apoc3
🎧 bit.ly/40Gv9hc
August 4, 2025 at 3:01 PM
James Joseph and Stella Hunter have a very important message for you (Part 1)
📖 books2read.com/apoc3
🎧 bit.ly/40Gv9hc
📖 books2read.com/apoc3
🎧 bit.ly/40Gv9hc
August 7, 2025 at 8:00 PM
August 4, 2025 at 7:02 PM
August 4, 2025 at 5:00 PM
Remarkable, groundbreaking progress for cardiometabolic science and medicine!!! #FGF21R #GLP1 #APOC3 #ANGPTL3 #PCSK9 #mAb #siRNA #ASO #CRISPRCas9
Shoutout to ♥️ basic and clinical scientists moving this forward for our patients! @ahascience.bsky.social #AHA25 #PrevCards #Lipidology
Shoutout to ♥️ basic and clinical scientists moving this forward for our patients! @ahascience.bsky.social #AHA25 #PrevCards #Lipidology
November 8, 2025 at 3:46 PM
Remarkable, groundbreaking progress for cardiometabolic science and medicine!!! #FGF21R #GLP1 #APOC3 #ANGPTL3 #PCSK9 #mAb #siRNA #ASO #CRISPRCas9
Shoutout to ♥️ basic and clinical scientists moving this forward for our patients! @ahascience.bsky.social #AHA25 #PrevCards #Lipidology
Shoutout to ♥️ basic and clinical scientists moving this forward for our patients! @ahascience.bsky.social #AHA25 #PrevCards #Lipidology
Are you ready for Malice? He's an angsty mfer.
Coming August 11
preorder books2read.com/apoc3
Start The Mate Games: Apocalypse books2read.com/apoc1
Coming August 11
preorder books2read.com/apoc3
Start The Mate Games: Apocalypse books2read.com/apoc1
July 23, 2025 at 3:01 PM
Are you ready for Malice? He's an angsty mfer.
Coming August 11
preorder books2read.com/apoc3
Start The Mate Games: Apocalypse books2read.com/apoc1
Coming August 11
preorder books2read.com/apoc3
Start The Mate Games: Apocalypse books2read.com/apoc1
August 13, 2025 at 8:01 PM