Despite global progress in vaccination and awareness, a quiet but troubling trend is gaining momentum: HPV-associated cancers are on the rise. While some types, like cervical cancer, have seen modest declines in countries with screening programs, others—particularly oropharyngeal cancers—are increasing, especially among men. This "silent surge" is raising alarm among public health experts. But it’s also fueling innovation. One of the most promising developments? The growing use of artificial intelligence (AI) to detect, diagnose, and personalize treatment for HPV-related cancers. With recent advances in histopathological AI, the future of HPV cancer care could be faster, smarter, and more equitable.