Structural investigations of unliganded murine KHK-A revealed the adoption of two conformations similar to those adopted by the human ortholog, suggesting this structural feature is conserved across species #PfkBFamily #Moonlighting #ProteinKinases doi.org/10.1107/S205...

This review highlights the role of #ProteinKinases in #NeurodegenerativeDiseases and explores kinase-targeted strategies—including inhibitors, #AntisenseOligonucleotides, and #GeneTherapy—for early intervention and disease management.

#OpenAccess in #STTT: doi.org/10.1038/s413...

Mutations within the predicted fragment-binding region of FAM83G/SACK1G abolish its interaction with the Ser/Thr kinase CK1α
Barton, G. J., Glennie, L. et al.
Paper
Details
#FAM83GMutation #CK1αInteraction #ProteinKinases

This article outlines the role of #ProteinKinases in #neurodegenerative diseases, reviews the progress of kinase inhibitors in #ClinicalTrials, and discusses the challenges & future directions of kinase-targeted therapies. #medsky

#STTT #OpenAccess: doi.org/10.1038/s413...

How can we reduce the risk of deadly inflammation like ARDS?
@UMBaltimore researchers at UMSOP and @UMSOM are exploring how protein kinases may help regulate immune response. #Science ARDS #HealthResearch #Inflammation #ProteinKinases #BreakthroughsCantWaitUMB

Reviewing the role of various #ProteinKinases in the #Pathogenesis of #Neurodegenerative (ND) diseases, with a discussion on the current progress of kinase inhibitors in #ClinicalTrials, the challenges, & future prospects.

#STTT #OpenAccess: doi.org/10.1038/s413...