Bryan Roth
@zenbrainest.bsky.social
James Black: 'the prismatic qualities of the assay distort our view in obscure ways and degrees'
Pinned
Bryan Roth
@zenbrainest.bsky.social
· Mar 20
The structural diversity of psychedelic drug actions revealed - Nature Communications
The authors present 7 cryo-EM structures of hallucinogenic and non-hallucinogenic compounds across multiple chemotypes bound to the 5-HT2A receptor, shedding light onto ligand specificity and sig...
www.nature.com
Congrats to all —essential reading for those interested in #psychedelics
www.nature.com/articles/s41...
www.nature.com/articles/s41...
IL-1R1-positive dorsal raphe neurons drive self-imposed social withdrawal in sickness: Cell www.cell.com/cell/fulltex...
IL-1R1-positive dorsal raphe neurons drive self-imposed social withdrawal in sickness
During sickness, animals exhibit prolonged social withdrawal, a response that may
limit disease spread. Elevated IL-1β levels during inflammation activate IL-1R1-expressing
neurons in the dorsal raphe...
www.cell.com
November 26, 2025 at 2:06 PM
IL-1R1-positive dorsal raphe neurons drive self-imposed social withdrawal in sickness: Cell www.cell.com/cell/fulltex...
Reposted by Bryan Roth
Distinct roles of prefrontal subregion feedback to the primary visual cortex across behavioral states: Neuron www.cell.com/neuron/fullt...
Distinct roles of prefrontal subregion feedback to the primary visual cortex across behavioral states
Ährlund-Richter et al. show that in mice, discrete subregions of the prefrontal cortex
send distinct feedback signals to the primary visual cortex. These pathways differentially
modulate visual proces...
www.cell.com
November 25, 2025 at 7:26 PM
Distinct roles of prefrontal subregion feedback to the primary visual cortex across behavioral states: Neuron www.cell.com/neuron/fullt...
Reposted by Bryan Roth
Properties and functions of transcriptionally distinct enteric neurons: Cell www.cell.com/cell/fulltex...
Properties and functions of transcriptionally distinct enteric neurons
Developing genetic access to transcriptionally distinct enteric neurons in vivo enables
the examination of morphological heterogeneity across cell types as well as cell-type-specific
influences on GI ...
www.cell.com
November 25, 2025 at 7:28 PM
Properties and functions of transcriptionally distinct enteric neurons: Cell www.cell.com/cell/fulltex...
Properties and functions of transcriptionally distinct enteric neurons: Cell www.cell.com/cell/fulltex...
Properties and functions of transcriptionally distinct enteric neurons
Developing genetic access to transcriptionally distinct enteric neurons in vivo enables
the examination of morphological heterogeneity across cell types as well as cell-type-specific
influences on GI ...
www.cell.com
November 25, 2025 at 7:28 PM
Properties and functions of transcriptionally distinct enteric neurons: Cell www.cell.com/cell/fulltex...
Distinct roles of prefrontal subregion feedback to the primary visual cortex across behavioral states: Neuron www.cell.com/neuron/fullt...
Distinct roles of prefrontal subregion feedback to the primary visual cortex across behavioral states
Ährlund-Richter et al. show that in mice, discrete subregions of the prefrontal cortex
send distinct feedback signals to the primary visual cortex. These pathways differentially
modulate visual proces...
www.cell.com
November 25, 2025 at 7:26 PM
Distinct roles of prefrontal subregion feedback to the primary visual cortex across behavioral states: Neuron www.cell.com/neuron/fullt...
Striatal cell-type specific encoding stability and reorganization for agency and habit www.biorxiv.org/content/10.1...
Striatal cell-type specific encoding stability and reorganization for agency and habit
Adaptive, goal-directed decision making requires agency, knowledge that an action will cause a particular outcome. For well-practiced routines, agency is relinquished in favor of automatic habits. Her...
www.biorxiv.org
November 25, 2025 at 5:07 PM
Striatal cell-type specific encoding stability and reorganization for agency and habit www.biorxiv.org/content/10.1...
When GRC's were cool!
Blast from the past 👵🏻
1997 catecholamines Gordon Research Conference
(when doing dopamine research was far less trendy but so much more fun)
1997 catecholamines Gordon Research Conference
(when doing dopamine research was far less trendy but so much more fun)
November 25, 2025 at 12:53 AM
When GRC's were cool!
Reposted by Bryan Roth
November 23, 2025 at 11:49 PM
November 23, 2025 at 11:49 PM
The polypharmacological profiles of xanomeline and N-desmethylxanomeline
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
a man wearing a pink shirt that says ' you should get yourself '
ALT: a man wearing a pink shirt that says ' you should get yourself '
media.tenor.com
November 23, 2025 at 6:13 PM
The polypharmacological profiles of xanomeline and N-desmethylxanomeline
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Bryan Roth
So many “new” ideas are old repackaged ones using updated terms based on current technologies.
Either folks need to read papers from > 5yrs ago. Or they need to cite them so readers & the public see the slow plodding incremental nature of discovery science.
#AcademicSky
Either folks need to read papers from > 5yrs ago. Or they need to cite them so readers & the public see the slow plodding incremental nature of discovery science.
#AcademicSky
November 23, 2025 at 4:05 PM
So many “new” ideas are old repackaged ones using updated terms based on current technologies.
Either folks need to read papers from > 5yrs ago. Or they need to cite them so readers & the public see the slow plodding incremental nature of discovery science.
#AcademicSky
Either folks need to read papers from > 5yrs ago. Or they need to cite them so readers & the public see the slow plodding incremental nature of discovery science.
#AcademicSky
Reposted by Bryan Roth
My favorite from an @hhmi.org scientist: “the great thing about optogenetics is it keeps the riff raff out of the field.”
Heard an established successful neuroscientist dismissing junior scientists as "people at the bottom" 🤦♀️
You folks with lots of research funds & power: young scientists more than ever need our respect and support even if you don't agree with their ideas and approaches
#sfn2025
You folks with lots of research funds & power: young scientists more than ever need our respect and support even if you don't agree with their ideas and approaches
#sfn2025
November 23, 2025 at 3:27 PM
My favorite from an @hhmi.org scientist: “the great thing about optogenetics is it keeps the riff raff out of the field.”
My favorite from an @hhmi.org scientist: “the great thing about optogenetics is it keeps the riff raff out of the field.”
Heard an established successful neuroscientist dismissing junior scientists as "people at the bottom" 🤦♀️
You folks with lots of research funds & power: young scientists more than ever need our respect and support even if you don't agree with their ideas and approaches
#sfn2025
You folks with lots of research funds & power: young scientists more than ever need our respect and support even if you don't agree with their ideas and approaches
#sfn2025
November 23, 2025 at 3:27 PM
My favorite from an @hhmi.org scientist: “the great thing about optogenetics is it keeps the riff raff out of the field.”
Reposted by Bryan Roth
Not sooooo bad: prompt draw a diagram of how 5-HT2A receptor activation induces dendritic spine formation.....I agree with much of this, surprisingly
November 22, 2025 at 11:23 PM
Not sooooo bad: prompt draw a diagram of how 5-HT2A receptor activation induces dendritic spine formation.....I agree with much of this, surprisingly
Not sooooo bad: prompt draw a diagram of how 5-HT2A receptor activation induces dendritic spine formation.....I agree with much of this, surprisingly
November 22, 2025 at 11:23 PM
Not sooooo bad: prompt draw a diagram of how 5-HT2A receptor activation induces dendritic spine formation.....I agree with much of this, surprisingly
Amazing paper--must read for #gpcr
It’s really meaningful to have such insightful coverage from a leader in the field @zenbrainest.bsky.social and Xianglin Huang. We appreciate the time they took to write up this very nice commentary!
November 22, 2025 at 1:35 AM
Amazing paper--must read for #gpcr
Reposted by Bryan Roth
The polypharmacological profiles of xanomeline and N-desmethylxanomeline https://www.biorxiv.org/content/10.1101/2025.11.20.689572v1
November 21, 2025 at 10:15 PM
The polypharmacological profiles of xanomeline and N-desmethylxanomeline https://www.biorxiv.org/content/10.1101/2025.11.20.689572v1
Reposted by Bryan Roth
Multiplexed imaging of G-proteins and ERK activity upon activation of CaSR www.biorxiv.org/content/10.1...
Multiplexed imaging of G-proteins and ERK activity upon activation of CaSR
We have previously shown that the calcium sensing receptor (CaSR) activates different G proteins and second messengers in single cells, and that GPCR and G protein-mediated ERK activity can be highly ...
www.biorxiv.org
November 20, 2025 at 11:19 PM
Multiplexed imaging of G-proteins and ERK activity upon activation of CaSR www.biorxiv.org/content/10.1...
This is wonderful but implementing it will be key.
In August, NIH institute and center directors received this document entitled "Achieving NIH Mission: Leveraging Funding Policies".
1/6
1/6
November 20, 2025 at 8:12 PM
This is wonderful but implementing it will be key.
Elucidating pathway-selective biased CCKBR agonism for Alzheimer’s disease treatment: Cell www.cell.com/cell/fulltex...
Elucidating pathway-selective biased CCKBR agonism for Alzheimer’s disease treatment
Clinical evidence from AD patients reveals an association between impaired CCKBR-Gq
signaling and disease severity, guiding structure-based design of a Gq-biased agonist
that rescues memory and pathol...
www.cell.com
November 20, 2025 at 6:01 PM
Elucidating pathway-selective biased CCKBR agonism for Alzheimer’s disease treatment: Cell www.cell.com/cell/fulltex...
LSD is an amazing molecule!
open.substack.com/pub/zendudes...
open.substack.com/pub/zendudes...
LSD is an amazing molecule!
For want of a single atom, the cosmos is lost.
open.substack.com
November 19, 2025 at 6:14 PM
LSD is an amazing molecule!
open.substack.com/pub/zendudes...
open.substack.com/pub/zendudes...
Reposted by Bryan Roth
Unmixing the Psychedelic Connectome: Brain Network Traits of Psilocybin https://www.biorxiv.org/content/10.1101/2025.11.17.688834v1
November 18, 2025 at 2:15 AM
Unmixing the Psychedelic Connectome: Brain Network Traits of Psilocybin https://www.biorxiv.org/content/10.1101/2025.11.17.688834v1