zack chiang
@zchiang.bsky.social
microscopy x epigenomics | buenrostro lab | harvard/broad
Pinned
zack chiang
@zchiang.bsky.social
· Nov 11
7 years ago, I met a junior fellow named Jason Buenrostro who blew me away with a vision of futuristic genomic technologies
Today, we (Ajay Labade, Caroline Comenho) are excited to share our first steps into that future: Expansion in situ genome sequencing
1/
Today, we (Ajay Labade, Caroline Comenho) are excited to share our first steps into that future: Expansion in situ genome sequencing
1/
What do you do when grants are cancelled, faculty searches are frozen, and the ability to do the science you believe in is slipping out of reach?
I wrote an essay. On efforts to solve aging with reprogramming, the primacy of the epigenome, and the path to rewriting our future:
I wrote an essay. On efforts to solve aging with reprogramming, the primacy of the epigenome, and the path to rewriting our future:
April 17, 2025 at 1:37 PM
What do you do when grants are cancelled, faculty searches are frozen, and the ability to do the science you believe in is slipping out of reach?
I wrote an essay. On efforts to solve aging with reprogramming, the primacy of the epigenome, and the path to rewriting our future:
I wrote an essay. On efforts to solve aging with reprogramming, the primacy of the epigenome, and the path to rewriting our future:
maybe we just need more positive visions of what the future could look like if we develop mirror life
December 13, 2024 at 8:11 PM
maybe we just need more positive visions of what the future could look like if we develop mirror life
nothing cooler than watching a friend literally turn science fiction into reality
it's been awe-inspiring to watch @andrewcpayne.bsky.social and co build E11 Bio and prove that the FRO model can produce amazing, unique science
also expansion + molecular barcoding <3
it's been awe-inspiring to watch @andrewcpayne.bsky.social and co build E11 Bio and prove that the FRO model can produce amazing, unique science
also expansion + molecular barcoding <3
🧪 E11 Bio is excited to share a major step towards brain mapping at 100x lower cost, making whole-brain connectomics at human & mouse scale feasible (🧠→🔬→💻). Critical for curing brain disorders, building human-like AI systems, and even simulating human brains.
Read more: e11.bio/news/roadmap
Read more: e11.bio/news/roadmap
December 3, 2024 at 7:56 PM
nothing cooler than watching a friend literally turn science fiction into reality
it's been awe-inspiring to watch @andrewcpayne.bsky.social and co build E11 Bio and prove that the FRO model can produce amazing, unique science
also expansion + molecular barcoding <3
it's been awe-inspiring to watch @andrewcpayne.bsky.social and co build E11 Bio and prove that the FRO model can produce amazing, unique science
also expansion + molecular barcoding <3
Reposted by zack chiang
Excited to see our T-cell exhaustion preprint published! This work is led by Tristan Tay and collaborators at AstraZeneca. See the sub-thread (reformatted for bluesky) originally composed and posted by the newly minted Dr. Tay
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Degradation of IKZF1 prevents epigenetic progression of T cell exhaustion in an antigen-specific assay
Tay et al. demonstrate an antigen-specific assay producing exhausted T cells that
reflect those found in human tumors. They identify IKZF1 (IKAROS) as a driver of exhaustion
progression and validate t...
www.cell.com
November 16, 2024 at 7:26 PM
Excited to see our T-cell exhaustion preprint published! This work is led by Tristan Tay and collaborators at AstraZeneca. See the sub-thread (reformatted for bluesky) originally composed and posted by the newly minted Dr. Tay
www.cell.com/cell-reports...
www.cell.com/cell-reports...
to shy posters, a reminder that you can literally just post about science you think is cool
& if you're looking for the next single-cell or spatial, I suspect single-molecule sequencing is about to blow up 👀
www.cell.com/cell/fulltex...
www.biorxiv.org/content/10.1...
www.nature.com/articles/s41...
& if you're looking for the next single-cell or spatial, I suspect single-molecule sequencing is about to blow up 👀
www.cell.com/cell/fulltex...
www.biorxiv.org/content/10.1...
www.nature.com/articles/s41...
The single-molecule accessibility landscape of newly replicated mammalian chromatin
By developing a long-read sequencing method to simultaneously map replication status
and protein-DNA contacts in cells, Ostrowski, Yang, et al. show that newly replicated
chromatin is enriched for unw...
www.cell.com
November 18, 2024 at 9:47 PM
to shy posters, a reminder that you can literally just post about science you think is cool
& if you're looking for the next single-cell or spatial, I suspect single-molecule sequencing is about to blow up 👀
www.cell.com/cell/fulltex...
www.biorxiv.org/content/10.1...
www.nature.com/articles/s41...
& if you're looking for the next single-cell or spatial, I suspect single-molecule sequencing is about to blow up 👀
www.cell.com/cell/fulltex...
www.biorxiv.org/content/10.1...
www.nature.com/articles/s41...
just a pic of my dog maple taking "be one with nature" a little too literally
November 17, 2024 at 6:44 PM
just a pic of my dog maple taking "be one with nature" a little too literally
November 15, 2024 at 7:02 PM
Reposted by zack chiang
New episode! This time on The Climate Biotech Podcast, Homeworld Collective co-founders Dan Goodwin and Paul Reginato sit down with the legendary George Church—a pioneer in genomics and synthetic biology.
Spotify: open.spotify.com/episode/6LfF...
Apple Podcasts: podcasts.apple.com/us/podcast/e...
Spotify: open.spotify.com/episode/6LfF...
Apple Podcasts: podcasts.apple.com/us/podcast/e...
November 14, 2024 at 6:36 PM
New episode! This time on The Climate Biotech Podcast, Homeworld Collective co-founders Dan Goodwin and Paul Reginato sit down with the legendary George Church—a pioneer in genomics and synthetic biology.
Spotify: open.spotify.com/episode/6LfF...
Apple Podcasts: podcasts.apple.com/us/podcast/e...
Spotify: open.spotify.com/episode/6LfF...
Apple Podcasts: podcasts.apple.com/us/podcast/e...
who knew it would be easier to get everyone to switch social media platforms than getting them to use hg38
November 14, 2024 at 6:45 PM
who knew it would be easier to get everyone to switch social media platforms than getting them to use hg38
Reposted by zack chiang
Leonid Mirny and I wrote this for all interested in chromosomes: "The chromosome folding problem and how cells solve it"
www.cell.com/action/showP...
www.cell.com/action/showP...
www.cell.com
November 14, 2024 at 4:02 PM
Leonid Mirny and I wrote this for all interested in chromosomes: "The chromosome folding problem and how cells solve it"
www.cell.com/action/showP...
www.cell.com/action/showP...
seems like a fun game for all the scientists excited by the move but also mourning having to rebuild their following (it me)
I once made a meme to explain all of the drama surrounding the word "epigenetics" - to my horror, it is now used in at least several PhD classes
I once made a meme to explain all of the drama surrounding the word "epigenetics" - to my horror, it is now used in at least several PhD classes
November 13, 2024 at 1:21 AM
seems like a fun game for all the scientists excited by the move but also mourning having to rebuild their following (it me)
I once made a meme to explain all of the drama surrounding the word "epigenetics" - to my horror, it is now used in at least several PhD classes
I once made a meme to explain all of the drama surrounding the word "epigenetics" - to my horror, it is now used in at least several PhD classes
Reposted by zack chiang
Just published: "Multiplexed expansion revealing for imaging multiprotein nanostructures in healthy and diseased brain", led by Jinyoung Kang and Margaret Schroeder! multiExR enables antibody staining of >20 proteins in a sample w/registration error down to 25 nm. www.nature.com/articles/s41...
Multiplexed expansion revealing for imaging multiprotein nanostructures in healthy and diseased brain - Nature Communications
Mapping the nature of multiprotein nanostructures in cellular contexts remains challenging. Here, Kang and Schroeder et al. report multiplexed expansion revealing, a technique which expands proteins a...
www.nature.com
November 10, 2024 at 10:26 PM
Just published: "Multiplexed expansion revealing for imaging multiprotein nanostructures in healthy and diseased brain", led by Jinyoung Kang and Margaret Schroeder! multiExR enables antibody staining of >20 proteins in a sample w/registration error down to 25 nm. www.nature.com/articles/s41...
7 years ago, I met a junior fellow named Jason Buenrostro who blew me away with a vision of futuristic genomic technologies
Today, we (Ajay Labade, Caroline Comenho) are excited to share our first steps into that future: Expansion in situ genome sequencing
1/
Today, we (Ajay Labade, Caroline Comenho) are excited to share our first steps into that future: Expansion in situ genome sequencing
1/
November 11, 2024 at 7:33 PM
7 years ago, I met a junior fellow named Jason Buenrostro who blew me away with a vision of futuristic genomic technologies
Today, we (Ajay Labade, Caroline Comenho) are excited to share our first steps into that future: Expansion in situ genome sequencing
1/
Today, we (Ajay Labade, Caroline Comenho) are excited to share our first steps into that future: Expansion in situ genome sequencing
1/