tumors traditionally considered immune-cold. We demonstrate that these macrophages contribute to relapse by fostering a chronically activated, metabolically stressed, and immunosuppressive environment. And special thanks to my collabrators @alvarokohn.bsky.social, Vessela,
Arnoldo and Mads

Macrophages located close to (distant from) specific epithelial cells have a negative (positive) effect on survival. These nearby macrophages are associated with immunosuppression, an observation validated using scRNA-seq data. Notably, this phenomenon occurs in ER+ breast... 4/n

There are cell types that show a positive (or negative) association with response to NAC and a negative (or positive) association with relapse. Macrophages are among these cell types.
2. The spatial location of macrophages can influence how they are associated with relapse. 3/n

And we have interesting results:
1: Response to neoadjuvant chemo and relapse do not align as one might expect. Even within subtypes of breast tumors, traditionally considered more homogeneous, one subset can exhibit a better response rate but worse survival. Respectively, 2/n