Ayşe Seda Yazgılı
@yazgili.bsky.social
Postdoctoral Research Scientist 👩🔬
Colorectal Cancer and Wnt Signalling Group
CRUK Scotland Institute
Colorectal Cancer and Wnt Signalling Group
CRUK Scotland Institute
Reposted by Ayşe Seda Yazgılı
Online Now: Paneth-like transition drives resistance to dual targeting of KRAS and EGFR in colorectal cancer
Paneth-like transition drives resistance to dual targeting of KRAS and EGFR in colorectal cancer
Zhang et al. show that CRC cells adopt a Paneth-like state to evade dual KRAS and EGFR inhibition. They identify a SMAD1-FGFR3 axis that drives lineage plasticity and MAPK reactivation, conferring resistance. FGFR3 co-targeting blocks this transition, offering a strategy to improve the durability of KRAS-EGFR combination therapies.
dlvr.it
November 17, 2025 at 7:51 PM
Online Now: Paneth-like transition drives resistance to dual targeting of KRAS and EGFR in colorectal cancer
Reposted by Ayşe Seda Yazgılı
✨Thrilled to announce an exciting opportunity to work on our project exploring WNT-driven cell competition as a novel preventative strategy in CRC 🧬
We’re hiring a Senior Scientific Officer to join me in @owen_sansom’s lab. Great science and lots of room to make an impact! 👩🏽🔬
We’re hiring a Senior Scientific Officer to join me in @owen_sansom’s lab. Great science and lots of room to make an impact! 👩🏽🔬
We are recruiting a Senior Scientific Officer to work with @nadianasreddin.bsky.social in the Sansom lab on the project WNT-driven cell competition: a target for novel preventative strategies against colorectal adenoma formation
📅Apply by 15 August 2025
www.crukscotlandinstitute.ac.uk/careers/
📅Apply by 15 August 2025
www.crukscotlandinstitute.ac.uk/careers/
July 25, 2025 at 10:51 PM
✨Thrilled to announce an exciting opportunity to work on our project exploring WNT-driven cell competition as a novel preventative strategy in CRC 🧬
We’re hiring a Senior Scientific Officer to join me in @owen_sansom’s lab. Great science and lots of room to make an impact! 👩🏽🔬
We’re hiring a Senior Scientific Officer to join me in @owen_sansom’s lab. Great science and lots of room to make an impact! 👩🏽🔬
What I love about science is that every day, you can be a scientist, but also a teacher, student, explorer, investigator, mentor, organizer, and more! It’s a thrillling rollercoaster 🎢
I nominate @ppcenteno.bsky.social @skw0294.bsky.social @verondejesus.bsky.social
#IWD2025 #AccelerateAction
I nominate @ppcenteno.bsky.social @skw0294.bsky.social @verondejesus.bsky.social
#IWD2025 #AccelerateAction
What I love most about my-day-to-day in science is the investigative/inquisitive aspect of research. I’m always learning something new and it often gets me out my comfort zone 👩🏽🔬
I nominate @yazgili.bsky.social @jbirchj.bsky.social @rosalinsimpson.bsky.social
#IWD2025 #AccelerateAction
I nominate @yazgili.bsky.social @jbirchj.bsky.social @rosalinsimpson.bsky.social
#IWD2025 #AccelerateAction
Women in cancer research are driving innovation, discovery, and impact every day—let’s amplify their stories and celebrate our diverse community! 👩🔬✨
Join the challenge: Answer a question, share your response with #IWD2025 #AccelerateAction, tag 3 others to keep going! 🚀💜
Join the challenge: Answer a question, share your response with #IWD2025 #AccelerateAction, tag 3 others to keep going! 🚀💜
March 4, 2025 at 7:33 AM
What I love about science is that every day, you can be a scientist, but also a teacher, student, explorer, investigator, mentor, organizer, and more! It’s a thrillling rollercoaster 🎢
I nominate @ppcenteno.bsky.social @skw0294.bsky.social @verondejesus.bsky.social
#IWD2025 #AccelerateAction
I nominate @ppcenteno.bsky.social @skw0294.bsky.social @verondejesus.bsky.social
#IWD2025 #AccelerateAction
Reposted by Ayşe Seda Yazgılı
What I love most about my-day-to-day in science is the investigative/inquisitive aspect of research. I’m always learning something new and it often gets me out my comfort zone 👩🏽🔬
I nominate @yazgili.bsky.social @jbirchj.bsky.social @rosalinsimpson.bsky.social
#IWD2025 #AccelerateAction
I nominate @yazgili.bsky.social @jbirchj.bsky.social @rosalinsimpson.bsky.social
#IWD2025 #AccelerateAction
Women in cancer research are driving innovation, discovery, and impact every day—let’s amplify their stories and celebrate our diverse community! 👩🔬✨
Join the challenge: Answer a question, share your response with #IWD2025 #AccelerateAction, tag 3 others to keep going! 🚀💜
Join the challenge: Answer a question, share your response with #IWD2025 #AccelerateAction, tag 3 others to keep going! 🚀💜
March 3, 2025 at 6:51 PM
What I love most about my-day-to-day in science is the investigative/inquisitive aspect of research. I’m always learning something new and it often gets me out my comfort zone 👩🏽🔬
I nominate @yazgili.bsky.social @jbirchj.bsky.social @rosalinsimpson.bsky.social
#IWD2025 #AccelerateAction
I nominate @yazgili.bsky.social @jbirchj.bsky.social @rosalinsimpson.bsky.social
#IWD2025 #AccelerateAction