Yang Luo
@y-luo.bsky.social
Group Leader @OxfordUni working on MHC, immune-mediated traits, multi-ancestry and omics studies
Some talks are good, some are exciting, and some are truly inspirational. This is one of them — “Smarter trials for better health” by Sir Martin Landray. @martinlandray.bsky.social
November 12, 2025 at 12:06 PM
Some talks are good, some are exciting, and some are truly inspirational. This is one of them — “Smarter trials for better health” by Sir Martin Landray. @martinlandray.bsky.social
Great to host Fan at Kennedy - explainable AI model in single cell!
September 26, 2025 at 9:42 AM
Great to host Fan at Kennedy - explainable AI model in single cell!
Summer outing for the team — feeling very fortunate to work with such talented and wonderful people.
July 30, 2025 at 7:03 PM
Summer outing for the team — feeling very fortunate to work with such talented and wonderful people.
🔍 As expected, the strongest trans-regulation of TCRs occurs in the MHC region.
What’s interesting 🤨 is that HLA-associated V genes were less stable across treatment. Notably, patients with HLA-regulated TCR clones showed improved overall survival.
What’s interesting 🤨 is that HLA-associated V genes were less stable across treatment. Notably, patients with HLA-regulated TCR clones showed improved overall survival.
July 28, 2025 at 10:09 AM
🔍 As expected, the strongest trans-regulation of TCRs occurs in the MHC region.
What’s interesting 🤨 is that HLA-associated V genes were less stable across treatment. Notably, patients with HLA-regulated TCR clones showed improved overall survival.
What’s interesting 🤨 is that HLA-associated V genes were less stable across treatment. Notably, patients with HLA-regulated TCR clones showed improved overall survival.
🧬 In this study, we analysed the genetic regulation of CD8+ TCRs in 250 cancer patients, before and after ICB treatment.
July 28, 2025 at 10:09 AM
🧬 In this study, we analysed the genetic regulation of CD8+ TCRs in 250 cancer patients, before and after ICB treatment.
Sarah, a talented master student in the group, is presenting her (4-week-long) work on multi-ancestry HLA-pQTLs at Human Proteome and Health meeting today @ox.ac.uk! 🥳
June 24, 2025 at 1:05 PM
Sarah, a talented master student in the group, is presenting her (4-week-long) work on multi-ancestry HLA-pQTLs at Human Proteome and Health meeting today @ox.ac.uk! 🥳
Proud supervisor moment - well done Jennie! @kennedydatascience.bsky.social
June 12, 2025 at 7:21 PM
Proud supervisor moment - well done Jennie! @kennedydatascience.bsky.social
Jennie is giving a brilliant seminar summarising her DPhil work on context- and cell type-specific single cell eQTLs so far #proudPImoment
March 5, 2025 at 12:57 PM
Jennie is giving a brilliant seminar summarising her DPhil work on context- and cell type-specific single cell eQTLs so far #proudPImoment
Amazing line up from the lab this morning @bdi to talk about HLA-TCR interaction at both bulk and single cell level
February 18, 2025 at 12:11 PM
Amazing line up from the lab this morning @bdi to talk about HLA-TCR interaction at both bulk and single cell level
Yearly lab updates:
1️⃣ Two brilliant postdocs joined the team!
2️⃣ Our first preprint is out (www.biorxiv.org/content/10.1...) stay tuned! 📄
3️⃣ a newly awarded WT Early Career Fellow
4️⃣ UK International Student Excellence Award (x.com/Ruthnanje/st...)
Felling blessed with an amazing team! 🙌😊
1️⃣ Two brilliant postdocs joined the team!
2️⃣ Our first preprint is out (www.biorxiv.org/content/10.1...) stay tuned! 📄
3️⃣ a newly awarded WT Early Career Fellow
4️⃣ UK International Student Excellence Award (x.com/Ruthnanje/st...)
Felling blessed with an amazing team! 🙌😊
December 7, 2024 at 10:26 AM
Yearly lab updates:
1️⃣ Two brilliant postdocs joined the team!
2️⃣ Our first preprint is out (www.biorxiv.org/content/10.1...) stay tuned! 📄
3️⃣ a newly awarded WT Early Career Fellow
4️⃣ UK International Student Excellence Award (x.com/Ruthnanje/st...)
Felling blessed with an amazing team! 🙌😊
1️⃣ Two brilliant postdocs joined the team!
2️⃣ Our first preprint is out (www.biorxiv.org/content/10.1...) stay tuned! 📄
3️⃣ a newly awarded WT Early Career Fellow
4️⃣ UK International Student Excellence Award (x.com/Ruthnanje/st...)
Felling blessed with an amazing team! 🙌😊
On the pathogen side, we observed that the interacting strains have altered redox states due to thioredoxin reductase mutations.
November 30, 2024 at 12:30 PM
On the pathogen side, we observed that the interacting strains have altered redox states due to thioredoxin reductase mutations.
Taking this observation further, we experimentally assessed the responses of human macrophages from TB donors with different host genotypes to different Mtb infections. We observed that hosts with interacting variants exhibited stronger interferon gene signatures.
November 30, 2024 at 12:29 PM
Taking this observation further, we experimentally assessed the responses of human macrophages from TB donors with different host genotypes to different Mtb infections. We observed that hosts with interacting variants exhibited stronger interferon gene signatures.
Strikingly, we identified a unique subclade of Mtb lineage 2 that interacts with human variants within the MHC region.
November 30, 2024 at 12:28 PM
Strikingly, we identified a unique subclade of Mtb lineage 2 that interacts with human variants within the MHC region.
📣Happy to share my first bluesky post with a new publication!https://www.nature.com/articles/s41467-024-54741-w?utm_source=rct_congratemailt&utm_medium=email&utm_campaign=oa_20241129&utm_content=10.1038/s41467-024-54741-w
November 30, 2024 at 12:27 PM
📣Happy to share my first bluesky post with a new publication!https://www.nature.com/articles/s41467-024-54741-w?utm_source=rct_congratemailt&utm_medium=email&utm_campaign=oa_20241129&utm_content=10.1038/s41467-024-54741-w