Xin Zeng
@xzeng.bsky.social
Computational postdoc fellow at Siepel Lab, Cold Spring Harbor Lab. Interested in modeling transcriptional regulation by machine learning methods.
https://xzengcombio.github.io/
https://xzengcombio.github.io/
Pinned
Xin Zeng
@xzeng.bsky.social
· Dec 10
Comparative single-cell transcriptomic analysis reveals putative differentiation drivers and potential origin of vertebrate retina
Abstract. Despite known single-cell expression profiles in vertebrate retinas, understanding of their developmental and evolutionary expression patterns am
academic.oup.com
Reposted by Xin Zeng
🎥 Video: See chromatin in action — each dot is a single nucleosome, dynamically fluctuating in a living HeLa cell (TMR-labeled, 50 ms/frame).
🔬 Original paper: www.science.org/doi/full/10....
🔬 Original paper: www.science.org/doi/full/10....
Single-nucleosome imaging reveals steady-state motion of interphase chromatin in living human cells
Local chromatin motion remains steady during interphase, allowing cells to conduct housekeeping tasks under similar environments.
www.science.org
April 25, 2025 at 12:24 AM
🎥 Video: See chromatin in action — each dot is a single nucleosome, dynamically fluctuating in a living HeLa cell (TMR-labeled, 50 ms/frame).
🔬 Original paper: www.science.org/doi/full/10....
🔬 Original paper: www.science.org/doi/full/10....
Reposted by Xin Zeng
[SAVE THE DATE] MLCB 2025 is happening Sept 10-11 at the NY Genome Center in NYC!
Attend the premier conference at the intersection of ML & Bio, share your research and make lasting connections!
Submission deadline: June 1
More details: mlcb.github.io
Help spread the word—please RT! #MLCB2025
Attend the premier conference at the intersection of ML & Bio, share your research and make lasting connections!
Submission deadline: June 1
More details: mlcb.github.io
Help spread the word—please RT! #MLCB2025
February 5, 2025 at 2:50 AM
[SAVE THE DATE] MLCB 2025 is happening Sept 10-11 at the NY Genome Center in NYC!
Attend the premier conference at the intersection of ML & Bio, share your research and make lasting connections!
Submission deadline: June 1
More details: mlcb.github.io
Help spread the word—please RT! #MLCB2025
Attend the premier conference at the intersection of ML & Bio, share your research and make lasting connections!
Submission deadline: June 1
More details: mlcb.github.io
Help spread the word—please RT! #MLCB2025
Reposted by Xin Zeng
New publication
www.nature.com/articles/s41...
www.nature.com/articles/s41...
STAIG: Spatial transcriptomics analysis via image-aided graph contrastive learning for domain exploration and alignment-free integration - Nature Communications
Spatial transcriptomics maps gene expression in tissues to study cellular interactions. Here, authors introduce STAIG, a deep-learning model that integrates multimodal data without pre-alignment, remo...
www.nature.com
January 28, 2025 at 12:43 AM
New publication
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Xin Zeng
Ever wondered how transcription choreographs histone modifications? Our work reveals the basis of co-transcriptional H3K36me3 by SETD2. We visualize how a histone writer coordinates with the transcription machinery! This is the magnus opus of @jonmarkert.bsky.social!
tinyurl.com/setd2
tinyurl.com/setd2
December 12, 2024 at 7:16 PM
Ever wondered how transcription choreographs histone modifications? Our work reveals the basis of co-transcriptional H3K36me3 by SETD2. We visualize how a histone writer coordinates with the transcription machinery! This is the magnus opus of @jonmarkert.bsky.social!
tinyurl.com/setd2
tinyurl.com/setd2
Reposted by Xin Zeng
Excited for Biological Data Science @CSHL!
Would love to meet new peeps and chat about BioML!
I'll be presenting Fri at 9:20a on "Designing DNA with tunable regulatory activity using discrete diffusion"
Jessica Zhou (postdoc): "Uncertainty-aware genomic deep learning with knowledge distillation"
Would love to meet new peeps and chat about BioML!
I'll be presenting Fri at 9:20a on "Designing DNA with tunable regulatory activity using discrete diffusion"
Jessica Zhou (postdoc): "Uncertainty-aware genomic deep learning with knowledge distillation"
November 13, 2024 at 2:56 PM
Excited for Biological Data Science @CSHL!
Would love to meet new peeps and chat about BioML!
I'll be presenting Fri at 9:20a on "Designing DNA with tunable regulatory activity using discrete diffusion"
Jessica Zhou (postdoc): "Uncertainty-aware genomic deep learning with knowledge distillation"
Would love to meet new peeps and chat about BioML!
I'll be presenting Fri at 9:20a on "Designing DNA with tunable regulatory activity using discrete diffusion"
Jessica Zhou (postdoc): "Uncertainty-aware genomic deep learning with knowledge distillation"
Reposted by Xin Zeng
Hi Bluesky! I made a 3D chromatin starter pack.
Let me know if you would like to be added.
go.bsky.app/6tTQdqQ
Let me know if you would like to be added.
go.bsky.app/6tTQdqQ
November 13, 2024 at 5:55 PM
Hi Bluesky! I made a 3D chromatin starter pack.
Let me know if you would like to be added.
go.bsky.app/6tTQdqQ
Let me know if you would like to be added.
go.bsky.app/6tTQdqQ