Xiekui Cui
@xiekuicui.bsky.social
Reposted by Xiekui Cui
Nature research paper: Integrated analysis of the complete sequence of a macaque genome
https://go.nature.com/4ihe4kb
https://go.nature.com/4ihe4kb
Integrated analysis of the complete sequence of a macaque genome - Nature
A complete genome assembly of a crab-eating macaque, revealing 46% fewer segmental duplications and 3.83 times longer centromeres than those of humans, is presented, enhancing understanding of lineage-specific phenotypes, adaptation and primate evolution.
go.nature.com
February 27, 2025 at 6:37 PM
Nature research paper: Integrated analysis of the complete sequence of a macaque genome
https://go.nature.com/4ihe4kb
https://go.nature.com/4ihe4kb
Reposted by Xiekui Cui
Very nice work by @xiekuicui.bsky.social & Han Yang (Yin Shen lab; also K. Pollard @brainevodevo.bsky.social), providing a detailed characterization of human accelerated regions in neurons. Prime-editing experiments highlight differences in neuritogenesis between humans and chimps 🧪🧬🧠
@nature.com
@nature.com
Comparative characterization of human accelerated regions in neurons - Nature
The cis-regulatory functions of human accelerated regions of genomic loci and their potential contribution to human brain evolution are revealed.
www.nature.com
February 27, 2025 at 10:30 AM
Very nice work by @xiekuicui.bsky.social & Han Yang (Yin Shen lab; also K. Pollard @brainevodevo.bsky.social), providing a detailed characterization of human accelerated regions in neurons. Prime-editing experiments highlight differences in neuritogenesis between humans and chimps 🧪🧬🧠
@nature.com
@nature.com
Reposted by Xiekui Cui
Decisive results from @atreyop.bsky.social in @noonanlab.bsky.social lab showing that Human accelerated regions (HARs) regulate largely conserved target genes compared to great apes but can change their spatio-temporal patterns of expression. 👇
Out today in Cell: a comprehensive map of Human Accelerated Region gene targets in human and chimpanzee neural stem cells. Thread:
authors.elsevier.com/a/1kWzdL7PXu...
www.cell.com/cell/fulltex...
authors.elsevier.com/a/1kWzdL7PXu...
www.cell.com/cell/fulltex...
Resolving the three-dimensional interactome of human accelerated regions during human and chimpanzee neurodevelopment
Human accelerated regions (HARs) have been implicated in human brain evolution with
limited understanding of the biological processes they alter. This study reports that
HARs influenced brain evolutio...
www.cell.com
February 6, 2025 at 2:39 AM
Decisive results from @atreyop.bsky.social in @noonanlab.bsky.social lab showing that Human accelerated regions (HARs) regulate largely conserved target genes compared to great apes but can change their spatio-temporal patterns of expression. 👇