Xavier Tao
@xaviertao.bsky.social
PhD candidate & NSF Fellow, Woo Lab, Harvard.
UC Berkeley Nomura & Keasling Lab alum.
Chemical biology, medicinal chemistry, targeted protein degradation.
UC Berkeley Nomura & Keasling Lab alum.
Chemical biology, medicinal chemistry, targeted protein degradation.
Reposted by Xavier Tao
Nature research paper: Identification of an allosteric site on the E3 ligase adapter cereblon
go.nature.com/3NHFcPj
go.nature.com/3NHFcPj
Identification of an allosteric site on the E3 ligase adapter cereblon - Nature
An allosteric site on the E3 ligase adapter cereblon can be targeted to modulate the efficacy of cereblon in targeted protein degradation applications.
go.nature.com
January 22, 2026 at 7:19 PM
Nature research paper: Identification of an allosteric site on the E3 ligase adapter cereblon
go.nature.com/3NHFcPj
go.nature.com/3NHFcPj
Reposted by Xavier Tao
we hope you enjoyed this paper as much as we do! 😉😘
if you’re interested in working with an allosteric ligand, reach out to Prof. Woo 🫡 we’re more than happy to share 🙌🏼🩵✨ #thefutureisallostery #CRBN #TPD
if you’re interested in working with an allosteric ligand, reach out to Prof. Woo 🫡 we’re more than happy to share 🙌🏼🩵✨ #thefutureisallostery #CRBN #TPD
Pour a glass of champagne AND red Bordeaux—Our newest work with GSK @scripps.edu is out in @nature.com! Here we describe SB-405483, the first allosteric CRBN ligand which potentiates neosubstrate degradation. Congrats Vanessa and all authors! 🍷💫💐 www.nature.com/articles/s41...
January 22, 2026 at 7:45 PM
we hope you enjoyed this paper as much as we do! 😉😘
if you’re interested in working with an allosteric ligand, reach out to Prof. Woo 🫡 we’re more than happy to share 🙌🏼🩵✨ #thefutureisallostery #CRBN #TPD
if you’re interested in working with an allosteric ligand, reach out to Prof. Woo 🫡 we’re more than happy to share 🙌🏼🩵✨ #thefutureisallostery #CRBN #TPD
Happy to see this work on the first allosteric cereblon (CRBN) ligand out! E3 ligase allostery holds great promise for modulating targeted protein degradation. Huge thank you to all the collaborators for making this research possible!
Pour a glass of champagne AND red Bordeaux—Our newest work with GSK @scripps.edu is out in @nature.com! Here we describe SB-405483, the first allosteric CRBN ligand which potentiates neosubstrate degradation. Congrats Vanessa and all authors! 🍷💫💐 www.nature.com/articles/s41...
January 22, 2026 at 8:55 AM
Happy to see this work on the first allosteric cereblon (CRBN) ligand out! E3 ligase allostery holds great promise for modulating targeted protein degradation. Huge thank you to all the collaborators for making this research possible!