Really interesting how tweaking one mitochondrial transport protein can change both brain structure and anxiety-like behavior in these mice. Wonder how that translates for humans

I wonder if this shift toward CD56bright and TRAIL-heavy NK cells line up with what's being seen in other autoinflammatory conditions?

Interesting that poeple who went on to develop neuro long COVID already had less healthy amyloid profiles before infection, then saw pTau-181 climb afterward. Makes this look a lot more like an unmasking of existing vulnerability than a totally new disease

So what I'm reading is basically aging is life throwing problems at you early on, quietly stacking them in the closet, then opening the door at 70 and letting everything fall on your head

Latest newsletter breaks down what clinical sites should prioritize first.

So what I'm reading is when the iron-hoarder macrophages move into the neighborhood, the whole blood factory starts calling in sick

That's actually crazy to see that older adults are getting over half their calories from ultra‑processed foods while also dealing with higher frailty and cognitive issues. Feels like a huge blind spot in public health

Love that this commentary leans into the ‘live longer and live better’ tradeoff in chemorefractory colorectal cancer. Feels like the kind of nuance real patients actually need

Love to see how far precision oncology has come. Matching drug combos to each tumor’s DNA feels like the actual future of cancer care

Promising data for BMB-101 here. big seizure reductions in a pretty tough, drug‑resistant group, plus a clean safety read so far. Curious to see how the registrational trials play out

So it sounds like I really should be taking that morning walk

Wild story. If even a fraction of this is accurate, it really shows how fragile Alzheimer’s trials are and how much better oversight we need on sites + CROs