Wafik S. El-Deiry, MD, PhD, FACP
@weldeiry.bsky.social
Physician-Scientist Oncologist, Director Legorreta Cancer Center, Associate Dean, past Faculty Exec Cmte member, Brown Univ, ACS Professor, Chair, WIN Consortium in Precision Oncology, Entrepreneur, Boat Captain, joined Nov 16 ‘24 Pubs: tinyurl.com/s98xg3u
Pinned
I’m here at @BrownUniversity Family Weekend on the College Green to speak with you about exciting developments at the #LegorretaCancerCenter over the last few years. As a colon cancer doctor my messa...
TikTok video by weldeiry
www.tiktok.com
On 10-26-2024 I was at Brown University Family Weekend on College Green to share exciting progress at #LegorretaCancerCenter.
As a colon cancer doctor my message was to make sure you get your screening colonoscopy to prevent colon cancer as this could save your life.
www.tiktok.com/t/ZTYLaQo9J/
As a colon cancer doctor my message was to make sure you get your screening colonoscopy to prevent colon cancer as this could save your life.
www.tiktok.com/t/ZTYLaQo9J/
Dr. El-Deiry announces the launch of the Legorreta Cancer Center Director’s Podcast youtu.be/iHOaybv4Pfk via @YouTube
Dr. El-Deiry announces the launch of the Legorreta Cancer Center Director's Podcast
YouTube video by weldeiry
youtu.be
November 17, 2025 at 8:42 PM
Dr. El-Deiry announces the launch of the Legorreta Cancer Center Director’s Podcast youtu.be/iHOaybv4Pfk via @YouTube
A lengthy rebuttal👇
I generally agree with letting experts do what they’re good at with oversight to monitor integrity, ethics and safety risks.
A rebuttal to NIH leadership's screed against pandemic preparedness.
insidemedicine.substack.com/p/a-rebuttal...
I generally agree with letting experts do what they’re good at with oversight to monitor integrity, ethics and safety risks.
A rebuttal to NIH leadership's screed against pandemic preparedness.
insidemedicine.substack.com/p/a-rebuttal...
November 16, 2025 at 11:57 PM
A lengthy rebuttal👇
I generally agree with letting experts do what they’re good at with oversight to monitor integrity, ethics and safety risks.
A rebuttal to NIH leadership's screed against pandemic preparedness.
insidemedicine.substack.com/p/a-rebuttal...
I generally agree with letting experts do what they’re good at with oversight to monitor integrity, ethics and safety risks.
A rebuttal to NIH leadership's screed against pandemic preparedness.
insidemedicine.substack.com/p/a-rebuttal...
Empathy is very important but there need to be safeguards against betrayal after trust is built👇
Artificial intelligence shows more empathy towards patients than doctors do
www.earth.com/news/artific...
Artificial intelligence shows more empathy towards patients than doctors do
www.earth.com/news/artific...
Artificial intelligence shows more empathy towards patients than doctors do
A sweeping meta-analysis of 15 studies found patients consistently rate AI chatbots as having more empathy than real clinicians.
www.earth.com
November 16, 2025 at 11:36 PM
Empathy is very important but there need to be safeguards against betrayal after trust is built👇
Artificial intelligence shows more empathy towards patients than doctors do
www.earth.com/news/artific...
Artificial intelligence shows more empathy towards patients than doctors do
www.earth.com/news/artific...
Aging represses oncogenic KRAS-driven lung tumorigenesis and alters tumor suppression
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Aging represses oncogenic KRAS-driven lung tumorigenesis and alters tumor suppression - Nature Aging
The mechanisms that impact tumorigenesis during aging are incompletely understood. Here Shuldiner et al. show that in mice, aging represses KRAS-driven lung tumorigenesis and dampens the impact of ina...
www.nature.com
November 16, 2025 at 9:31 PM
Aging represses oncogenic KRAS-driven lung tumorigenesis and alters tumor suppression
www.nature.com/articles/s43...
www.nature.com/articles/s43...
I wish to live in a world where science and medicine are about seeking and propagating truth to help humanity. A world where freedom of thought, civil discourse, and creativity matter rather than one where injustice, politics, narrow-mindedness, bigoted racism and ad hominem attacks are commonplace.
November 16, 2025 at 3:28 PM
I wish to live in a world where science and medicine are about seeking and propagating truth to help humanity. A world where freedom of thought, civil discourse, and creativity matter rather than one where injustice, politics, narrow-mindedness, bigoted racism and ad hominem attacks are commonplace.
Jay Bhattacharya, Matthew J. Memoli
NIH Directors: The World Needs a New Pandemic Playbook
The old one failed to cope with Covid and may even have caused it.
www.city-journal.org/article/nih-...
NIH Directors: The World Needs a New Pandemic Playbook
The old one failed to cope with Covid and may even have caused it.
www.city-journal.org/article/nih-...
NIH Directors: The World Needs a New Pandemic Playbook
The old one failed to cope with Covid and may even have caused it.
www.city-journal.org
November 16, 2025 at 1:17 AM
Jay Bhattacharya, Matthew J. Memoli
NIH Directors: The World Needs a New Pandemic Playbook
The old one failed to cope with Covid and may even have caused it.
www.city-journal.org/article/nih-...
NIH Directors: The World Needs a New Pandemic Playbook
The old one failed to cope with Covid and may even have caused it.
www.city-journal.org/article/nih-...
Remembering Sir William Osler👇
Strategies to Reinvigorate the Bedside Clinical Encounter
www.nejm.org/doi/full/10....
Strategies to Reinvigorate the Bedside Clinical Encounter
www.nejm.org/doi/full/10....
Strategies to Reinvigorate the Bedside Clinical Encounter | NEJM
Bedside clinical skills have been diminished by an overreliance on technology. This
article presents educational strategies for reinvigorating the bedside encounter and
shows how much can be learne...
www.nejm.org
November 15, 2025 at 7:34 PM
Remembering Sir William Osler👇
Strategies to Reinvigorate the Bedside Clinical Encounter
www.nejm.org/doi/full/10....
Strategies to Reinvigorate the Bedside Clinical Encounter
www.nejm.org/doi/full/10....
Hydralazine inhibits cysteamine dioxygenase to treat preeclampsia and senesce glioblastoma
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Hydralazine inhibits cysteamine dioxygenase to treat preeclampsia and senesce glioblastoma
The decades-old preeclampsia drug hydralazine vasodilates and senesces glioblastoma cells via the same enzyme target, ADO.
www.science.org
November 15, 2025 at 4:38 PM
Hydralazine inhibits cysteamine dioxygenase to treat preeclampsia and senesce glioblastoma
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
MD Anderson launches historic $2.5 billion campaign to end cancer
www.news-medical.net/news/2025111...
www.news-medical.net/news/2025111...
MD Anderson launches historic $2.5 billion campaign to end cancer
The University of Texas MD Anderson Cancer Center today launches its historic $2.5 billion comprehensive philanthropic campaign, Only Possible Here, The Campaign to End Cancer.
www.news-medical.net
November 15, 2025 at 3:15 PM
MD Anderson launches historic $2.5 billion campaign to end cancer
www.news-medical.net/news/2025111...
www.news-medical.net/news/2025111...
Skin cancer cluster found in 15 Pennsylvania counties with or near farmland
www.psu.edu/news/researc...
www.psu.edu/news/researc...
Skin cancer cluster found in 15 Pennsylvania counties with or near farmland | Penn State University
Counties in Pennsylvania that contained or were near cultivated cropland had significantly higher melanoma rates compared to other regions, according to a new study led by scientists at Penn State.
www.psu.edu
November 15, 2025 at 3:08 PM
Skin cancer cluster found in 15 Pennsylvania counties with or near farmland
www.psu.edu/news/researc...
www.psu.edu/news/researc...
Characterization of the tumor microbiome of brain metastases and glioblastoma reveals tumor-type-specific and location-specific microbial signatures
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Characterization of the tumor microbiome of brain metastases and glioblastoma reveals tumor-type-specific and location-specific microbial signatures - Nature Cancer
Using multiple visualization and profiling methods, Gigi et al. characterize the microbiome diversity of 322 brain tumors including brain metastases and glioblastomas.
www.nature.com
November 15, 2025 at 3:05 PM
Characterization of the tumor microbiome of brain metastases and glioblastoma reveals tumor-type-specific and location-specific microbial signatures
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Serotonin Could Play an Unexpected Role in Cancer, Scientists Discover
www.sciencealert.com/serotonin-co...
www.sciencealert.com/serotonin-co...
Serotonin Could Play an Unexpected Role in Cancer, Scientists Discover
Serotonin is often described as the happiness chemical because of its well-known role in regulating mood.
www.sciencealert.com
November 15, 2025 at 3:02 PM
Serotonin Could Play an Unexpected Role in Cancer, Scientists Discover
www.sciencealert.com/serotonin-co...
www.sciencealert.com/serotonin-co...
Pleased to share review by Claire Lin et al. from @bcarneiro7 @BrownMedicine @BrownUnivHealth @BrownUniversity #LegorretaCancerCenter @LiangChengMD @mhadfield30
The evolving landscape of antibody-drug conjugates (ADCs) for treatment of prostate cancer
pubmed.ncbi.nlm.nih.gov/41238753/
The evolving landscape of antibody-drug conjugates (ADCs) for treatment of prostate cancer
pubmed.ncbi.nlm.nih.gov/41238753/
The evolving landscape of antibody-drug conjugates (ADCs) for treatment of prostate cancer - PubMed
Advances in antibody-drug conjugate (ADC) technology and identification of new antigen targets are repositioning ADCs as a promising therapeutic platform for metastatic castration-resistant prostate cancer (mCRPC). This review summarizes recent progress in ADC payload and linker chemistry, highlight …
pubmed.ncbi.nlm.nih.gov
November 15, 2025 at 12:21 PM
Pleased to share review by Claire Lin et al. from @bcarneiro7 @BrownMedicine @BrownUnivHealth @BrownUniversity #LegorretaCancerCenter @LiangChengMD @mhadfield30
The evolving landscape of antibody-drug conjugates (ADCs) for treatment of prostate cancer
pubmed.ncbi.nlm.nih.gov/41238753/
The evolving landscape of antibody-drug conjugates (ADCs) for treatment of prostate cancer
pubmed.ncbi.nlm.nih.gov/41238753/
Stuck here in Chicago’s O’Hare Airport this evening after being rebooked on a later flight due to delay in Boston earlier.
November 13, 2025 at 11:34 PM
Stuck here in Chicago’s O’Hare Airport this evening after being rebooked on a later flight due to delay in Boston earlier.
Pleased to share collaborative study by De Souza et al. from @bcarneiro7 at @BrownMedicine #LegorretaCancerCenter
BrUOG360: A phase Ib/II study of copanlisib in combination with rucaparib in patients with metastatic castration-resistant prostate cancer (mCRPC)
pubmed.ncbi.nlm.nih.gov/41231232/
BrUOG360: A phase Ib/II study of copanlisib in combination with rucaparib in patients with metastatic castration-resistant prostate cancer (mCRPC)
pubmed.ncbi.nlm.nih.gov/41231232/
BrUOG360: A phase Ib/II study of copanlisib in combination with rucaparib in patients with metastatic castration-resistant prostate cancer (mCRPC) - PubMed
Copa/R had a favorable safety profile with a signal of efficacy supporting future studies of PARPi with PI3Ki.
pubmed.ncbi.nlm.nih.gov
November 13, 2025 at 10:28 PM
Pleased to share collaborative study by De Souza et al. from @bcarneiro7 at @BrownMedicine #LegorretaCancerCenter
BrUOG360: A phase Ib/II study of copanlisib in combination with rucaparib in patients with metastatic castration-resistant prostate cancer (mCRPC)
pubmed.ncbi.nlm.nih.gov/41231232/
BrUOG360: A phase Ib/II study of copanlisib in combination with rucaparib in patients with metastatic castration-resistant prostate cancer (mCRPC)
pubmed.ncbi.nlm.nih.gov/41231232/
Pleased to share collaborative study by Singh et al. from Professor Clark Chen’s group at @BrownMedicine #LegorretaCancerCenter
Feedforward miR-181d degradation modulates population variance of methyl-guanine methyl transferase and temozolomide resistance
pubmed.ncbi.nlm.nih.gov/41217933/
Feedforward miR-181d degradation modulates population variance of methyl-guanine methyl transferase and temozolomide resistance
pubmed.ncbi.nlm.nih.gov/41217933/
Feedforward miR-181d degradation modulates population variance of methyl-guanine methyl transferase and temozolomide resistance - PubMed
Intratumoral heterogeneity plays a pivotal role in cancer evolution, providing the substrate for adaptation to selective pressures, including chemotherapy treatment. Here, we demonstrate that miR-181d modulates variability in methyl-guanine methyl transferase (MGMT) expression, contributing to this …
pubmed.ncbi.nlm.nih.gov
November 13, 2025 at 10:17 PM
Pleased to share collaborative study by Singh et al. from Professor Clark Chen’s group at @BrownMedicine #LegorretaCancerCenter
Feedforward miR-181d degradation modulates population variance of methyl-guanine methyl transferase and temozolomide resistance
pubmed.ncbi.nlm.nih.gov/41217933/
Feedforward miR-181d degradation modulates population variance of methyl-guanine methyl transferase and temozolomide resistance
pubmed.ncbi.nlm.nih.gov/41217933/
High clinical actionability of a pan-cancer tissue-based combined DNA and RNA next generation sequencing assay in a diverse Asian population
www.nature.com/articles/s41...
www.nature.com/articles/s41...
High clinical actionability of a pan-cancer tissue-based combined DNA and RNA next generation sequencing assay in a diverse Asian population - npj Precision Oncology
npj Precision Oncology - High clinical actionability of a pan-cancer tissue-based combined DNA and RNA next generation sequencing assay in a diverse Asian population
www.nature.com
November 13, 2025 at 10:02 PM
High clinical actionability of a pan-cancer tissue-based combined DNA and RNA next generation sequencing assay in a diverse Asian population
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Concerning New Research Reveals Colon Cancer Is Skyrocketing in Adults Under 50
scitechdaily.com/concerning-n...
scitechdaily.com/concerning-n...
Concerning New Research Reveals Colon Cancer Is Skyrocketing in Adults Under 50
Colorectal cancer is striking younger adults at alarming rates, driven by lifestyle and genetic factors. Colorectal cancer (CRC) develops when abnormal cells grow uncontrollably in the colon or rectum...
scitechdaily.com
November 13, 2025 at 9:59 PM
Concerning New Research Reveals Colon Cancer Is Skyrocketing in Adults Under 50
scitechdaily.com/concerning-n...
scitechdaily.com/concerning-n...
Ultraprocessed Foods Linked to Colorectal Cancer Risk in Women Under 50
www.nytimes.com/2025/11/13/w...
www.nytimes.com/2025/11/13/w...
Ultraprocessed Foods Linked to Colorectal Cancer Risk in Women Under 50
www.nytimes.com
November 13, 2025 at 9:56 PM
Ultraprocessed Foods Linked to Colorectal Cancer Risk in Women Under 50
www.nytimes.com/2025/11/13/w...
www.nytimes.com/2025/11/13/w...