Virginie Tardif - San Martin
@vtardifsm.bsky.social
Cardio-immunologist
Assistant Prof CPJ U1180-Paris Saclay
🧫🧪🧑🔬 🫀🐢
Former Chaire excellence Cardioimmuno U1096-Rouen
Former Instructor HIV-cTFh at Drexel university, Philly, PA
Former Research Associate Autoimmunity- Therapy Innovation, TSRI, La Jolla, CA
Assistant Prof CPJ U1180-Paris Saclay
🧫🧪🧑🔬 🫀🐢
Former Chaire excellence Cardioimmuno U1096-Rouen
Former Instructor HIV-cTFh at Drexel university, Philly, PA
Former Research Associate Autoimmunity- Therapy Innovation, TSRI, La Jolla, CA
La plus belle journée de l’année 🥰
May 25, 2025 at 7:17 AM
La plus belle journée de l’année 🥰
Reposted by Virginie Tardif - San Martin
Unraveling the Role of Ctla-4 in Intestinal Immune Homeostasis: Insights from a novel Zebrafish Model of Inflammatory Bowel Disease https://www.biorxiv.org/content/10.1101/2024.07.24.604955v1
Unraveling the Role of Ctla-4 in Intestinal Immune Homeostasis: Insights from a novel Zebrafish Model of Inflammatory Bowel Disease https://www.biorxiv.org/content/10.1101/2024.07.24.604955v1
Inflammatory bowel disease (IBD) is a chronic and relapsing immune-mediated disorder characterized b
www.biorxiv.org
July 24, 2024 at 11:17 PM
Unraveling the Role of Ctla-4 in Intestinal Immune Homeostasis: Insights from a novel Zebrafish Model of Inflammatory Bowel Disease https://www.biorxiv.org/content/10.1101/2024.07.24.604955v1
Reposted by Virginie Tardif - San Martin
2️⃣ Using a cSCC model, we reveal that cancer cells change their IC ligand profile according to their epithelial/mesenchymal features, dictating the IC pathways involved in immune evasion: epithelial cancer cells via PD-1/L1 and mesenchymal cancer cells via CTLA-4/CD80 & TIGIT/CD155
November 21, 2024 at 3:52 PM
2️⃣ Using a cSCC model, we reveal that cancer cells change their IC ligand profile according to their epithelial/mesenchymal features, dictating the IC pathways involved in immune evasion: epithelial cancer cells via PD-1/L1 and mesenchymal cancer cells via CTLA-4/CD80 & TIGIT/CD155
Reposted by Virginie Tardif - San Martin
CTLA-4-expressing ILC3s restrain interleukin-23-mediated inflammation
CTLA-4-expressing ILC3s restrain interleukin-23-mediated inflammation
Nature, Published online: 12 June 2024; doi:10.1038/s41586-024-07537-3 Subsets of ILC3s upregulate the immunoregulatory checkpoint molecule CTLA-4 after stimulation in a microbiota-dependent manner, and advances to support CTLA-4+ ILC3s may represent a treatment opportunity in IL-23-driven chronic inflammation.
www.nature.com
June 12, 2024 at 5:57 PM
CTLA-4-expressing ILC3s restrain interleukin-23-mediated inflammation
Reposted by Virginie Tardif - San Martin
Microbiota-dependent activation of CD4+ T cells induces CTLA-4 blockade–associated colitis via Fcγ receptors
Microbiota-dependent activation of CD4+ T cells induces CTLA-4 blockade–associated colitis via Fcγ receptors
Science, Volume 383, Issue 6678 , Page 62-70, January 2024.
www.science.org
January 4, 2024 at 9:03 PM
Microbiota-dependent activation of CD4+ T cells induces CTLA-4 blockade–associated colitis via Fcγ receptors