Victor Dubach
@vicsnor.bsky.social
PhD student @bjmurphylab.bsky.social @mpibp.bsky.social with @imprs-cbp.bsky.social
Interested in #cryoEM 🔬❄️, redox and membrane proteins
Interested in #cryoEM 🔬❄️, redox and membrane proteins
Reposted by Victor Dubach
It’s out! Using cryo-ET in Dicty cells, we take a fresh in situ look at vaults. Surprisingly, we uncover vaults associated with ER and NE membranes, and find that many vaults enclose ribosomes in defined orientations, opening new avenues to their cellular function! www.biorxiv.org/lookup/conte...
December 16, 2025 at 8:17 AM
It’s out! Using cryo-ET in Dicty cells, we take a fresh in situ look at vaults. Surprisingly, we uncover vaults associated with ER and NE membranes, and find that many vaults enclose ribosomes in defined orientations, opening new avenues to their cellular function! www.biorxiv.org/lookup/conte...
Reposted by Victor Dubach
Yesterday I finally defended my PhD thesis - time to say thank you to all those who were part of this journey as mentors, collaborators, colleagues and friends!
November 7, 2025 at 3:49 PM
Yesterday I finally defended my PhD thesis - time to say thank you to all those who were part of this journey as mentors, collaborators, colleagues and friends!
Reposted by Victor Dubach
Just published! We share an open-source workflow to measure membrane thickness from tomograms, including a tutorial with 3D visualizations. We analyze thickness variations across organelles and reflect on where to define a membrane boundary. @becklab.bsky.social #teamtomo rupress.org/jcb/article/...
November 6, 2025 at 7:38 AM
Just published! We share an open-source workflow to measure membrane thickness from tomograms, including a tutorial with 3D visualizations. We analyze thickness variations across organelles and reflect on where to define a membrane boundary. @becklab.bsky.social #teamtomo rupress.org/jcb/article/...
Reposted by Victor Dubach
Exciting week in Frankfurt! Our CEOS energy filter and ASI Timepix3 are installed and we're looking forward to running the first tests :) #CryoEM #timepix #REELanalysis #4DSTEM @mpibp.bsky.social
November 5, 2025 at 12:12 PM
Exciting week in Frankfurt! Our CEOS energy filter and ASI Timepix3 are installed and we're looking forward to running the first tests :) #CryoEM #timepix #REELanalysis #4DSTEM @mpibp.bsky.social
Reposted by Victor Dubach
Our first lab paper is out! We identify and solve the first structure of the SND3 translocon involved in fungal membrane protein insertion. Congratulations @tzujingyang.bsky.social, and our colleagues @saumyakm.bsky.social, @hummerlab.bsky.social and Julian Langer. Read more ⬇️ and ➡️ rdcu.be/eNgIO
SNDing proteins into the membrane! Our new publication from @melaniemcdowell.bsky.social ’s group identifies the SND3 protein as a new route for membrane protein insertion! 🍄 📘 Read more here: www.mpg.de/25599408/102... Image: Louise Duever.
October 30, 2025 at 5:42 PM
Our first lab paper is out! We identify and solve the first structure of the SND3 translocon involved in fungal membrane protein insertion. Congratulations @tzujingyang.bsky.social, and our colleagues @saumyakm.bsky.social, @hummerlab.bsky.social and Julian Langer. Read more ⬇️ and ➡️ rdcu.be/eNgIO
Reposted by Victor Dubach
SNDing proteins into the membrane! Our new publication from @melaniemcdowell.bsky.social ’s group identifies the SND3 protein as a new route for membrane protein insertion! 🍄 📘 Read more here: www.mpg.de/25599408/102... Image: Louise Duever.
October 30, 2025 at 8:55 AM
SNDing proteins into the membrane! Our new publication from @melaniemcdowell.bsky.social ’s group identifies the SND3 protein as a new route for membrane protein insertion! 🍄 📘 Read more here: www.mpg.de/25599408/102... Image: Louise Duever.
Reposted by Victor Dubach
Heartfelt congratulations to @ralfsteinhilper.bsky.social @bjmurphylab.bsky.social on successfully defending his PhD thesis with summa cum laude! 👏💪🏆 For his doctoral research, Ralf used anaerobic sample preparation to study redox enzymes by single-particle cryo-EM.🔬 #phdlife #biophysics #excellence
October 16, 2025 at 12:51 PM
Heartfelt congratulations to @ralfsteinhilper.bsky.social @bjmurphylab.bsky.social on successfully defending his PhD thesis with summa cum laude! 👏💪🏆 For his doctoral research, Ralf used anaerobic sample preparation to study redox enzymes by single-particle cryo-EM.🔬 #phdlife #biophysics #excellence
Reposted by Victor Dubach
Big thanks to everyone at @bjmurphylab.bsky.social and @mpibp.bsky.social for your support and for making this such an unforgettable time!
Heartfelt congratulations to @ralfsteinhilper.bsky.social @bjmurphylab.bsky.social on successfully defending his PhD thesis with summa cum laude! 👏💪🏆 For his doctoral research, Ralf used anaerobic sample preparation to study redox enzymes by single-particle cryo-EM.🔬 #phdlife #biophysics #excellence
October 16, 2025 at 8:10 PM
Big thanks to everyone at @bjmurphylab.bsky.social and @mpibp.bsky.social for your support and for making this such an unforgettable time!
Reposted by Victor Dubach
Our yearly retreat brought together our PhD students 👩🔬from Frankfurt and Mainz for a journey of science and community building in the mountains of Switzerland! 🏔️ #gradschool #imprs_cbp
Photos: Vinay Singh
Photos: Vinay Singh
October 13, 2025 at 9:48 AM
Our yearly retreat brought together our PhD students 👩🔬from Frankfurt and Mainz for a journey of science and community building in the mountains of Switzerland! 🏔️ #gradschool #imprs_cbp
Photos: Vinay Singh
Photos: Vinay Singh
Reposted by Victor Dubach
❓What if you could peek between your tilt series ❓ We are proud to introduce cryoTIGER -- deep-learning based tilt interpolation for enhanced reconstruction in cryo-ET. A great collaboration between Turoňová lab, @becklab.bsky.social, @hummerlab.bsky.social #teamtomo www.nature.com/articles/s42...
cryoTIGER: deep-learning based tilt interpolation generator for enhanced reconstruction in cryo electron tomography - Communications Biology
Deep learning-based interpolation using cryoTIGER enhances angular sampling in cryoET, improving 3D reconstructions, particle localization, and structural recovery without increasing electron dose.
www.nature.com
October 10, 2025 at 10:35 AM
❓What if you could peek between your tilt series ❓ We are proud to introduce cryoTIGER -- deep-learning based tilt interpolation for enhanced reconstruction in cryo-ET. A great collaboration between Turoňová lab, @becklab.bsky.social, @hummerlab.bsky.social #teamtomo www.nature.com/articles/s42...
Reposted by Victor Dubach
🎉 Congratulations to our postdoc @sergiocruzleon.bsky.social for receiving the 2026 Theory & Computation Postdoctoral Research Award from the Biophysical Society! 🎉 Sergio will present his work at the Theory & Computation subgroup Symposium during the 2026 Biophysical Society meeting.
September 29, 2025 at 2:25 PM
🎉 Congratulations to our postdoc @sergiocruzleon.bsky.social for receiving the 2026 Theory & Computation Postdoctoral Research Award from the Biophysical Society! 🎉 Sergio will present his work at the Theory & Computation subgroup Symposium during the 2026 Biophysical Society meeting.
Reposted by Victor Dubach
🔬 Check out our new article on the mitochondrial TOM complex! Researchers from the Structural Biology Department have resolved a high-resolution structure of the main entry point for proteins into mitochondria. 🚪 🤩
Read more: www.biophys.mpg.de/2876415/tom-main-gate-into-mitochondria?c=2011019
Read more: www.biophys.mpg.de/2876415/tom-main-gate-into-mitochondria?c=2011019
Visualizing the Main Gate into Mitochondria
www.biophys.mpg.de
July 21, 2025 at 3:23 PM
🔬 Check out our new article on the mitochondrial TOM complex! Researchers from the Structural Biology Department have resolved a high-resolution structure of the main entry point for proteins into mitochondria. 🚪 🤩
Read more: www.biophys.mpg.de/2876415/tom-main-gate-into-mitochondria?c=2011019
Read more: www.biophys.mpg.de/2876415/tom-main-gate-into-mitochondria?c=2011019
Reposted by Victor Dubach
Proud to share our first lab pre-print: “SND3 is the membrane insertase within a fungal multipass translocon” where @tzujingyang.bsky.social solved the structure of a ribosome-associated SND3-translocon complex involved in ER membrane protein insertion ➡️ doi.org/10.1101/2025...
July 12, 2025 at 12:49 AM
Proud to share our first lab pre-print: “SND3 is the membrane insertase within a fungal multipass translocon” where @tzujingyang.bsky.social solved the structure of a ribosome-associated SND3-translocon complex involved in ER membrane protein insertion ➡️ doi.org/10.1101/2025...
Reposted by Victor Dubach
SND3 is the membrane insertase within a fungal multipass translocon https://www.biorxiv.org/content/10.1101/2025.07.08.663624v1
July 11, 2025 at 1:48 PM
SND3 is the membrane insertase within a fungal multipass translocon https://www.biorxiv.org/content/10.1101/2025.07.08.663624v1
Reposted by Victor Dubach
🎉We’re celebrating the #SCALE-it-Best-PhD-Awards-2025, honoring exceptional researchers! 🎓 This year, three remarkable dissertations were recognized, selected from a highly competitive and multidisciplinary pool of candidates. 🧵
June 5, 2025 at 9:41 AM
🎉We’re celebrating the #SCALE-it-Best-PhD-Awards-2025, honoring exceptional researchers! 🎓 This year, three remarkable dissertations were recognized, selected from a highly competitive and multidisciplinary pool of candidates. 🧵
Reposted by Victor Dubach
Looking for a tool to measure membrane thicknesses in tomograms (#TeamTomo)? Or curious about thickness differences within and across organelles? Check out my fellow @becklab.bsky.social PhD student @deglushk.bsky.social's excellent preprint:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
April 12, 2025 at 7:29 PM
Looking for a tool to measure membrane thicknesses in tomograms (#TeamTomo)? Or curious about thickness differences within and across organelles? Check out my fellow @becklab.bsky.social PhD student @deglushk.bsky.social's excellent preprint:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Victor Dubach
New preprint on 3D heterochromatin architecture in human cells! Great collab with @sergiocruzleon.bsky.social & @johannesbetz.bsky.social from @hummerlab.bsky.social, @marinalusic.bsky.social & the Turoňová lab. Many thanks to my supervisor @becklab.bsky.social. bioRxiv: tinyurl.com/3a74uanv 🧵👇
April 11, 2025 at 9:04 AM
New preprint on 3D heterochromatin architecture in human cells! Great collab with @sergiocruzleon.bsky.social & @johannesbetz.bsky.social from @hummerlab.bsky.social, @marinalusic.bsky.social & the Turoňová lab. Many thanks to my supervisor @becklab.bsky.social. bioRxiv: tinyurl.com/3a74uanv 🧵👇
Reposted by Victor Dubach
Get yourself a supervisor with whom you can laugh!
…So this happened two days ago… Incredibly grateful for all the fun and support over the years with @bjmurphylab.bsky.social and all the great people at @mpibp.bsky.social 🎓
…So this happened two days ago… Incredibly grateful for all the fun and support over the years with @bjmurphylab.bsky.social and all the great people at @mpibp.bsky.social 🎓
March 28, 2025 at 11:03 AM
Get yourself a supervisor with whom you can laugh!
…So this happened two days ago… Incredibly grateful for all the fun and support over the years with @bjmurphylab.bsky.social and all the great people at @mpibp.bsky.social 🎓
…So this happened two days ago… Incredibly grateful for all the fun and support over the years with @bjmurphylab.bsky.social and all the great people at @mpibp.bsky.social 🎓
Reposted by Victor Dubach
Happy International Women and Girls in STEM Day! Every mentor and act makes a difference - when we support a girl's curiosity or champion a female colleague, we inspire the next generation and one another. Let’s make STEM a place where all women & girls can thrive 🔬👩🏼🔬#WomenInSTEM
February 11, 2025 at 2:47 PM
Happy International Women and Girls in STEM Day! Every mentor and act makes a difference - when we support a girl's curiosity or champion a female colleague, we inspire the next generation and one another. Let’s make STEM a place where all women & girls can thrive 🔬👩🏼🔬#WomenInSTEM
Reposted by Victor Dubach
In case you wondered what it looks like "in real life" when the FluScreen of a Krios cryoEM is retracted/inserted: here you go. ❄️🔬
February 4, 2025 at 2:42 PM
In case you wondered what it looks like "in real life" when the FluScreen of a Krios cryoEM is retracted/inserted: here you go. ❄️🔬
Reposted by Victor Dubach
Exciting green news! 🦠 Do you know how certain microorganisms make a living by transforming CO2 into useful molecules? Check out our new work on the molecular choreography behind acetyl-CoA synthesis in the CODH/ACS protein complex. 👩🔬 🔗 www.biophys.mpg.de/2844976/micr...
January 31, 2025 at 1:14 PM
Exciting green news! 🦠 Do you know how certain microorganisms make a living by transforming CO2 into useful molecules? Check out our new work on the molecular choreography behind acetyl-CoA synthesis in the CODH/ACS protein complex. 👩🔬 🔗 www.biophys.mpg.de/2844976/micr...
Reposted by Victor Dubach
Congrats, Max! And big thanks and congratulations to our coauthors at MPI for Marine Microbiology, Bremen, MPI-CBG in Dresden, and in-house at the MPI of Biophysics! It's been great working with you all! @mpimarinemicrobio.bsky.social, @mpicbg.bsky.social sky.social, @hummerlab.bsky.social
Exciting green news! 🦠 Do you know how certain microorganisms make a living by transforming CO2 into useful molecules? Check out our new work on the molecular choreography behind acetyl-CoA synthesis in the CODH/ACS protein complex. 👩🔬 🔗 www.biophys.mpg.de/2844976/micr...
January 31, 2025 at 4:18 PM
Congrats, Max! And big thanks and congratulations to our coauthors at MPI for Marine Microbiology, Bremen, MPI-CBG in Dresden, and in-house at the MPI of Biophysics! It's been great working with you all! @mpimarinemicrobio.bsky.social, @mpicbg.bsky.social sky.social, @hummerlab.bsky.social
Reposted by Victor Dubach
I am very happy to share our latest work on the detailed cryo-EM structure of the NDH-PSI supercomplex of spinach. Thanks to Werner Kühlbrandt, Alex Hahn and @mpibp.bsky.social ! 🍃❄️🔬
You can find the paper in open access in Nature Structural and Molecular Biology:
www.nature.com/articles/s41...
You can find the paper in open access in Nature Structural and Molecular Biology:
www.nature.com/articles/s41...
Cryo-EM structure of the NDH–PSI–LHCI supercomplex from Spinacia oleracea - Nature Structural & Molecular Biology
Here, the authors report the structure of the nicotinamide adenine dinucleotide phosphate dehydrogenase–photosystem I–light-harvesting complex I supercomplex, providing insights into subunit interacti...
www.nature.com
January 27, 2025 at 12:18 PM
I am very happy to share our latest work on the detailed cryo-EM structure of the NDH-PSI supercomplex of spinach. Thanks to Werner Kühlbrandt, Alex Hahn and @mpibp.bsky.social ! 🍃❄️🔬
You can find the paper in open access in Nature Structural and Molecular Biology:
www.nature.com/articles/s41...
You can find the paper in open access in Nature Structural and Molecular Biology:
www.nature.com/articles/s41...
Reposted by Victor Dubach
Check out our latest publication in @naturecellbiology.bsky.social on the role of phase separation in selective autophagy initiation! This was done in a fantastic collaboration with
@kraftlabfr.bsky.social
www.nature.com/articles/s41...
Short teaser below 👇👇👇
@kraftlabfr.bsky.social
www.nature.com/articles/s41...
Short teaser below 👇👇👇
Phase separation of initiation hubs on cargo is a trigger switch for selective autophagy - Nature Cell Biology
Licheva, Pflaum, Babic, Mancilla et al. show that low-affinity cargo–receptor interactions promote autophagy receptor mobility and condensation of the scaffold protein Atg11 to trigger initiation hub ...
www.nature.com
January 8, 2025 at 3:11 PM
Check out our latest publication in @naturecellbiology.bsky.social on the role of phase separation in selective autophagy initiation! This was done in a fantastic collaboration with
@kraftlabfr.bsky.social
www.nature.com/articles/s41...
Short teaser below 👇👇👇
@kraftlabfr.bsky.social
www.nature.com/articles/s41...
Short teaser below 👇👇👇
Reposted by Victor Dubach
Hello bluesky, we’re excited to be here! To start off, we want to share our latest work on the FDX2-bound core ISC complex, which is now published in Nature Comms.
Congrats to @ralfsteinhilper.bsky.social and everyone else involved! 🎉
www.nature.com/articles/s41...
Congrats to @ralfsteinhilper.bsky.social and everyone else involved! 🎉
www.nature.com/articles/s41...
Two-stage binding of mitochondrial ferredoxin-2 to the core iron-sulfur cluster assembly complex - Nature Communications
De novo [2Fe-2S] cluster synthesis by the mitochondrial ISC complex requires electrons from ferredoxin-2 (FDX2). The authors map FDX2 binding to the core ISC complex, showing that FDX2 can bind in two...
www.nature.com
December 5, 2024 at 11:19 AM
Hello bluesky, we’re excited to be here! To start off, we want to share our latest work on the FDX2-bound core ISC complex, which is now published in Nature Comms.
Congrats to @ralfsteinhilper.bsky.social and everyone else involved! 🎉
www.nature.com/articles/s41...
Congrats to @ralfsteinhilper.bsky.social and everyone else involved! 🎉
www.nature.com/articles/s41...