The Venkatesh Lab
@venkatesh-lab.bsky.social
Cancer Neuroscience lab at Brigham and Women's Hospital/Harvard Medical School led by Dr. Humsa Venkatesh | http://venkateshlab.org | #cancerresearch #cancerneuroscience | Account managed by lab manager, tweets from PI will be signed.
Happy Halloween from the Venkatesh Lab! @mgbresearch.bsky.social
October 31, 2025 at 5:58 PM
Happy Halloween from the Venkatesh Lab! @mgbresearch.bsky.social
Venkatesh Lab Fall Outing -- Apple Picking!
October 27, 2025 at 8:04 PM
Venkatesh Lab Fall Outing -- Apple Picking!
Great to see all our student's shine at the @cshlnews.bsky.social's Biology of Cancer: Microenvironment & Metastasis meeting! Props to Rachel Davis & Hannah Farnsworth for a job well done on their poster presentations. Very proud of all our hardworking future PhDs!
September 18, 2025 at 1:11 PM
Great to see all our student's shine at the @cshlnews.bsky.social's Biology of Cancer: Microenvironment & Metastasis meeting! Props to Rachel Davis & Hannah Farnsworth for a job well done on their poster presentations. Very proud of all our hardworking future PhDs!
So proud of Lexi Franklin, who delivered an outstanding talk at @cshlnews.bsky.social’s Biology of Cancer: Microenvironment & Metastasis meeting yesterday! Keep an eye out for more exciting work from our lab, Rachel Davis and Hannah Farnsworth will be presenting their posters soon!
September 17, 2025 at 1:38 PM
So proud of Lexi Franklin, who delivered an outstanding talk at @cshlnews.bsky.social’s Biology of Cancer: Microenvironment & Metastasis meeting yesterday! Keep an eye out for more exciting work from our lab, Rachel Davis and Hannah Farnsworth will be presenting their posters soon!
In an effort to drive our work towards clinical translation, we treated SCLC brain allografts with Levetiracetam, and observed a decrease in tumor proliferation and tumor volume, highlighting the potential of therapeutic targeting neuron-SCLC interactions.
September 16, 2025 at 1:33 PM
In an effort to drive our work towards clinical translation, we treated SCLC brain allografts with Levetiracetam, and observed a decrease in tumor proliferation and tumor volume, highlighting the potential of therapeutic targeting neuron-SCLC interactions.
SCLC cells exhibit a reciprocal effect on neurons and contribute to their hyperexcitability, further driving neuron-SCLC interactions.
September 16, 2025 at 1:33 PM
SCLC cells exhibit a reciprocal effect on neurons and contribute to their hyperexcitability, further driving neuron-SCLC interactions.
Direct SCLC cell membrane depolarization is sufficient to promote the growth of SCLC tumors.
September 16, 2025 at 1:33 PM
Direct SCLC cell membrane depolarization is sufficient to promote the growth of SCLC tumors.
#SCLC cells in the brain co-opt neuronal activity-regulated mechanisms to promote growth and progression. Optogenetic stimulation of cortical neuronal activity via both glutamatergic and GABAergic circuits drives proliferation and invasion of SCLC.
September 16, 2025 at 1:33 PM
#SCLC cells in the brain co-opt neuronal activity-regulated mechanisms to promote growth and progression. Optogenetic stimulation of cortical neuronal activity via both glutamatergic and GABAergic circuits drives proliferation and invasion of SCLC.
In collaboration with the phenomenal electrophysiologist Wengang Wang and Bernardo Sabatini we demonstrate that SCLC cells exhibit electrical currents and consequent calcium transients in response to neuronal activity.
September 16, 2025 at 1:33 PM
In collaboration with the phenomenal electrophysiologist Wengang Wang and Bernardo Sabatini we demonstrate that SCLC cells exhibit electrical currents and consequent calcium transients in response to neuronal activity.
Using SCLC brain allograft model, we discover bona fide neuron-to-synapses SCLC, for the first time for tumors of non-CNS origin.
September 16, 2025 at 1:33 PM
Using SCLC brain allograft model, we discover bona fide neuron-to-synapses SCLC, for the first time for tumors of non-CNS origin.
We demonstrate that a population of #SCLC cells upregulates synaptic genes when exposed to neurons in activity-dependent manner. With @BizarMd team we further show overexpression of synaptic signature in patients with SCLC #brain metastasis compared to #SCLC lesions outside the brain.
September 16, 2025 at 1:33 PM
We found #vagus nerve transection starkly inhibits primary SCLC tumor formation in the lung, highlighting a critical role for innervation in SCLC initiation & progression. Shout out to pulmonary biologists Yin Liu & Mark Krasnow, and SCLC experts @juliensage.bsky.social and Fangfei Qu!
September 16, 2025 at 1:33 PM
We found #vagus nerve transection starkly inhibits primary SCLC tumor formation in the lung, highlighting a critical role for innervation in SCLC initiation & progression. Shout out to pulmonary biologists Yin Liu & Mark Krasnow, and SCLC experts @juliensage.bsky.social and Fangfei Qu!
Neurons and nerves regulate progression of several tumor types both in and outside of the central nervous system, but the extent to which the nervous system regulates lung cancer progression, either in the lung or when metastatic to brain, had yet to be explored.
September 16, 2025 at 1:33 PM
Neurons and nerves regulate progression of several tumor types both in and outside of the central nervous system, but the extent to which the nervous system regulates lung cancer progression, either in the lung or when metastatic to brain, had yet to be explored.
We are excited to welcome Jacqueline Garcia to the Venkatesh Lab! Jacqueline completed her PhD in Cellular, Molecular, & Developmental Biology at Tufts University Graduate School of Biomedical Sciences in 2025 as a member of Dr. Chris Dulla’s lab.
September 3, 2025 at 5:26 PM
We are excited to welcome Jacqueline Garcia to the Venkatesh Lab! Jacqueline completed her PhD in Cellular, Molecular, & Developmental Biology at Tufts University Graduate School of Biomedical Sciences in 2025 as a member of Dr. Chris Dulla’s lab.
The lab is celebrating Hannah Hoffman for a job well done and for passing her Preliminary Qualifying Exam! 🎇Congratulations Hannah!
March 27, 2025 at 6:55 PM
The lab is celebrating Hannah Hoffman for a job well done and for passing her Preliminary Qualifying Exam! 🎇Congratulations Hannah!
Do you have a background in cancer research or neuroscience? The Venkatesh Lab is expanding its team & seeking talented individuals at all levels. If you're passionate about cutting-edge research at the intersection of cancer and neuroscience, we'd love to hear from you!
February 5, 2025 at 4:48 PM
Do you have a background in cancer research or neuroscience? The Venkatesh Lab is expanding its team & seeking talented individuals at all levels. If you're passionate about cutting-edge research at the intersection of cancer and neuroscience, we'd love to hear from you!
Thanks to the efforts of our ephys scientist, Garrett Scarpa, and Scientifica, the Venkatesh lab has our ephys rig up and running!
February 3, 2025 at 3:02 PM
Thanks to the efforts of our ephys scientist, Garrett Scarpa, and Scientifica, the Venkatesh lab has our ephys rig up and running!
Happy holidays from the Venkatesh lab!! 🎄🌟
December 19, 2024 at 7:10 PM
Happy holidays from the Venkatesh lab!! 🎄🌟
So proud of rising cancer neuroscience superstars
@SavchukSol and Hannah Farnsworth on their beautiful presentations defining neuron brain tumor interactions at #SNO2024!
@SavchukSol and Hannah Farnsworth on their beautiful presentations defining neuron brain tumor interactions at #SNO2024!
November 27, 2024 at 7:41 PM
So proud of rising cancer neuroscience superstars
@SavchukSol and Hannah Farnsworth on their beautiful presentations defining neuron brain tumor interactions at #SNO2024!
@SavchukSol and Hannah Farnsworth on their beautiful presentations defining neuron brain tumor interactions at #SNO2024!
Join Dr. Venkatesh on December 5th for an engaging discussion on The Neural Regulation of Cancer and our lab's work. The event is free and open to the public as well as via zoom. Register here: tinyurl.com/3d42jf4n
November 22, 2024 at 2:27 PM
Join Dr. Venkatesh on December 5th for an engaging discussion on The Neural Regulation of Cancer and our lab's work. The event is free and open to the public as well as via zoom. Register here: tinyurl.com/3d42jf4n
#FluorescenceFriday offering for our new account!
SCLC Culture
SCLC Culture
November 8, 2024 at 8:45 PM
#FluorescenceFriday offering for our new account!
SCLC Culture
SCLC Culture