Kevin Van Bortle
@vanbortlelab.com
Asst. Professor of Cell & Dev. Bio at University of Illinois Urbana-Champaign
Interested in Pol III transcription, RNA~cancer biology, and genomics.
Previously Stanford | Emory | Rochester
vanbortlelab.com
Interested in Pol III transcription, RNA~cancer biology, and genomics.
Previously Stanford | Emory | Rochester
vanbortlelab.com
Reposted by Kevin Van Bortle
Reposted by Kevin Van Bortle
🚨New preprint from the lab🚨
🧬 What keeps certain chromatin domains anchored at the nuclear periphery? Our new genome-wide HiDRO screen uncovers a key role for RNA-binding protein hnRNPK.
www.biorxiv.org/content/10.1...
🧬 What keeps certain chromatin domains anchored at the nuclear periphery? Our new genome-wide HiDRO screen uncovers a key role for RNA-binding protein hnRNPK.
www.biorxiv.org/content/10.1...
Mechanistic and Epigenetic Partitioning of Lamina-Associated Chromatin Revealed by a Genome-Wide Imaging Screen
The nuclear periphery is a key site for heterochromatin organization in eukaryotic cells, where lamina-associated domains (LADs) promote transcriptional repression and genome stability. Despite their ...
www.biorxiv.org
August 14, 2025 at 7:01 PM
🚨New preprint from the lab🚨
🧬 What keeps certain chromatin domains anchored at the nuclear periphery? Our new genome-wide HiDRO screen uncovers a key role for RNA-binding protein hnRNPK.
www.biorxiv.org/content/10.1...
🧬 What keeps certain chromatin domains anchored at the nuclear periphery? Our new genome-wide HiDRO screen uncovers a key role for RNA-binding protein hnRNPK.
www.biorxiv.org/content/10.1...
Reposted by Kevin Van Bortle
So excited that our latest work is out! We have been working to understand how damaged tissue exits regeneration and returns to normal gene expression, and found a major role for the pioneer transcription factor Zelda in flies. Kudos to @anishbose.bsky.social @keatonschuster.bsky.social et al!
The pioneer transcription factor Zelda controls the exit from regeneration and restoration of patterning in Drosophila
The pioneer factor Zelda activates a specific set of developmental and structural genes to end tissue regeneration.
www.science.org
June 14, 2025 at 12:47 AM
So excited that our latest work is out! We have been working to understand how damaged tissue exits regeneration and returns to normal gene expression, and found a major role for the pioneer transcription factor Zelda in flies. Kudos to @anishbose.bsky.social @keatonschuster.bsky.social et al!
Reposted by Kevin Van Bortle
Another tour-de-force by the Xu lab #cryoEM
After the Pol II transcribing complexes (www.science.org/doi/10.1126/...), the Pol III transcribing complexes !!!
www.nature.com/articles/s41...
After the Pol II transcribing complexes (www.science.org/doi/10.1126/...), the Pol III transcribing complexes !!!
www.nature.com/articles/s41...
Structural insights into human Pol III transcription initiation in action - Nature
Reconstitution of seven human RNA polymerase III (Pol III) transcribing complexes (TC4/5/6/8/10/12/13) halted on U6 promoters with nascent RNAs of 4–13 nucleotides offers molecular insights into Pol I...
www.nature.com
June 5, 2025 at 9:14 AM
Another tour-de-force by the Xu lab #cryoEM
After the Pol II transcribing complexes (www.science.org/doi/10.1126/...), the Pol III transcribing complexes !!!
www.nature.com/articles/s41...
After the Pol II transcribing complexes (www.science.org/doi/10.1126/...), the Pol III transcribing complexes !!!
www.nature.com/articles/s41...
Reposted by Kevin Van Bortle
New research from the Kalsotra lab provides insight into maturation and specialization of the fetal liver and offers valuable information to the field of regenerative medicine.
Their findings were published in @genesdev.bsky.social
go.mcb.illinois.edu/liver
Congrats, @kalsotra-lab.bsky.social!
Their findings were published in @genesdev.bsky.social
go.mcb.illinois.edu/liver
Congrats, @kalsotra-lab.bsky.social!
January 31, 2025 at 7:27 PM
New research from the Kalsotra lab provides insight into maturation and specialization of the fetal liver and offers valuable information to the field of regenerative medicine.
Their findings were published in @genesdev.bsky.social
go.mcb.illinois.edu/liver
Congrats, @kalsotra-lab.bsky.social!
Their findings were published in @genesdev.bsky.social
go.mcb.illinois.edu/liver
Congrats, @kalsotra-lab.bsky.social!
Reposted by Kevin Van Bortle
Amid concerning times, sharing a bit of positivity: our 1st preprint of 2025 (funded VIA NIH COMMON FUND), heroically led by Marty Yang (@martyyang.bsky.social) w/ huge assist from @genophoria.bsky.social lab. Lots to cover so let’s get this tweetorial started (1/n)! www.biorxiv.org/content/10.1...
Pervasive and programmed nucleosome distortion patterns on single mammalian chromatin fibers
We present a genome-scale method to map the single-molecule co-occupancy of structurally distinct nucleosomes, subnucleosomes, and other protein-DNA interactions via long-read high-resolution adenine ...
www.biorxiv.org
January 24, 2025 at 1:04 AM
Amid concerning times, sharing a bit of positivity: our 1st preprint of 2025 (funded VIA NIH COMMON FUND), heroically led by Marty Yang (@martyyang.bsky.social) w/ huge assist from @genophoria.bsky.social lab. Lots to cover so let’s get this tweetorial started (1/n)! www.biorxiv.org/content/10.1...
Reposted by Kevin Van Bortle
Hello Bluesky friends! I am a #newPI starting at UC Irvine in April, interested in gene regulation and functional genomics in stem cell models of development (esp neural crest). We are hiring at all levels – please reach out/spread the word! sskimlab.org
Kim Lab at UC Irvine
Visit the post for more.
sskimlab.org
January 20, 2025 at 11:08 PM
Hello Bluesky friends! I am a #newPI starting at UC Irvine in April, interested in gene regulation and functional genomics in stem cell models of development (esp neural crest). We are hiring at all levels – please reach out/spread the word! sskimlab.org
Reposted by Kevin Van Bortle
🎇🎄Some holiday reading: Overdue TWEETORIAL on the latest preprint from our lab 🎇🎄
In this work, superstar postdoc @xinhexue.bsky.social combined 2 kinds of pooled CRISPR screens to pinpoint noncoding regulatory elements and the transcription factors that activate these elements.
In this work, superstar postdoc @xinhexue.bsky.social combined 2 kinds of pooled CRISPR screens to pinpoint noncoding regulatory elements and the transcription factors that activate these elements.
December 26, 2024 at 3:01 AM
🎇🎄Some holiday reading: Overdue TWEETORIAL on the latest preprint from our lab 🎇🎄
In this work, superstar postdoc @xinhexue.bsky.social combined 2 kinds of pooled CRISPR screens to pinpoint noncoding regulatory elements and the transcription factors that activate these elements.
In this work, superstar postdoc @xinhexue.bsky.social combined 2 kinds of pooled CRISPR screens to pinpoint noncoding regulatory elements and the transcription factors that activate these elements.