Ongoing trials @MSKCancerCenter
NUTRIVENTION2 NCT05640843 MGUS/SMM
NUTRIVENTION3 NCT05640843 MGUS/SMM
NUTRIVENTION4 NCT04497961 completed
NUTRIVENTION5 NCT07226609 in newly diagnosed MM recruiting
NUTRIVENTION-CH in clonal hematopoiesis
Interested? [email protected]

Sharing links to prior articles by @MSKCancerCenter @MSK_DeptOfMed about the experiences of two participants on this study #ASH25 #mmsm

www.mskcc.org/news/food-as...

www.mskcc.org/news/msk-res...

This work would not have been possible without funding support from multiple foundations and agencies @ash.hematology.org CRTI & Scholar, Allen Foundation, Inc, TREC, NCI K12, Riney Foundation, @mskcancercenter.bsky.social &
Matteo Bellone - AIRC and
@bloodcancerunited.bsky.social

I would like to take this opportunity to thank mentors, collaborators, coauthors, patients and study participants who believed in the importance of this work.
@healthtreeorg.bsky.social
@imfmyeloma.bsky.social
@themmrf.bsky.social

We show for the first time that a high-fiber diet is a low-risk intervention that may delay progression to myeloma. This project is truly team science and an amazing collaborative effort that spans multiple institutions, 3 countries and 7 years. #ASH25 #mmsm

Findings were translated to Vk*MYC mice modeling the MM-precursor state by Laura Cogrossi and Matteo Bellone in which a high-fiber diet delayed progression through improved metabolism, microbiome and SCFA production that reinvigorated anti-tumor immunity and inhibited tumor growth #mmsm

Consumption of a western diet and high BMI are risk factors for progression from pre-malignant phenotypes to cancer MM. In the NUTRIVENTION trial (NCT04920084), we administered a high-fiber, plant-based diet to 23 pts with MM precursor states and elevated BMI. #mmsm #ASH25

As a Hodgkin lymphoma survivor and an oncologist, I’ve found that “What should I eat?” is one of the most common Qs patients with cancer ask - yet often the hardest one to answer. This Q stayed with me, and in 2019 it sparked a deeper curiosity that led to the NUTRIVENTION Trials

Drugs such as GLP-1RAs and lifestyle strategies such as fiber rich diets highlight potential strategies for MM risk reduction to reduce the significant financial, emotional, and social burden of this diagnosis.

haematologica.org/article/view...

#mmsm #myeloma #obesity #diabetes

MM is almost twice as common in NHBs although we find that only an additional 2-4% of MM cases in NHB are due to excess BMI compared to NHWs.

haematologica.org/article/view...

#mmsm #myeloma #obesity #diabetes

It was streamed only for registered conference attendees.