Uri Alon
@urialonlab.bsky.social
The Alon lab explores design principles of biological circuits, focusing on systems medicine, aging, and healthspan.
It struck me that I spent 25 years building and nurturing this group, longer than my marriage or children, which has great power and meaning. (2/2)
April 23, 2025 at 12:07 PM
It struck me that I spent 25 years building and nurturing this group, longer than my marriage or children, which has great power and meaning. (2/2)
Work by Dr. Alon bar, Ron Moran. With Netta Mendelson Cohen, Avi Mayo, Yael Korem-Kohanim, Yoel Toledano, Clalit Healthcare.
Read the complete story here:
www.science.org/doi/10.1126/...
Read the complete story here:
www.science.org/doi/10.1126/...
Pregnancy and postpartum dynamics revealed by millions of lab tests
Analysis of 300,000 pregnancies shows detailed physiological changes at weekly resolution in health and complications.
www.science.org
March 27, 2025 at 12:44 PM
Work by Dr. Alon bar, Ron Moran. With Netta Mendelson Cohen, Avi Mayo, Yael Korem-Kohanim, Yoel Toledano, Clalit Healthcare.
Read the complete story here:
www.science.org/doi/10.1126/...
Read the complete story here:
www.science.org/doi/10.1126/...
Pregnancy is a dynamic process, stretching physiological control to the extreme with lasting postpartum effects.
We now have a deeper understanding of physiological adaptation.
We now have a deeper understanding of physiological adaptation.
March 27, 2025 at 12:44 PM
Pregnancy is a dynamic process, stretching physiological control to the extreme with lasting postpartum effects.
We now have a deeper understanding of physiological adaptation.
We now have a deeper understanding of physiological adaptation.
In pregnancies with complications (pre-eclampsia, gestational diabetes, postpartum hemorrhage),
distinct deviations from healthy profiles were evident. Gestational diabetes, in particular, showed marked changes, mostly in the pre-conception period.
distinct deviations from healthy profiles were evident. Gestational diabetes, in particular, showed marked changes, mostly in the pre-conception period.
March 27, 2025 at 12:44 PM
In pregnancies with complications (pre-eclampsia, gestational diabetes, postpartum hemorrhage),
distinct deviations from healthy profiles were evident. Gestational diabetes, in particular, showed marked changes, mostly in the pre-conception period.
distinct deviations from healthy profiles were evident. Gestational diabetes, in particular, showed marked changes, mostly in the pre-conception period.
The study also spans 20 weeks pre-conception, where we see changes in folic acid, CRP, and albumin levels.
These hint lifestyle changes such as a healthier diet and taking recommended supplements, supporting healthy fetal development.
These hint lifestyle changes such as a healthier diet and taking recommended supplements, supporting healthy fetal development.
March 27, 2025 at 12:44 PM
The study also spans 20 weeks pre-conception, where we see changes in folic acid, CRP, and albumin levels.
These hint lifestyle changes such as a healthier diet and taking recommended supplements, supporting healthy fetal development.
These hint lifestyle changes such as a healthier diet and taking recommended supplements, supporting healthy fetal development.
Nearly half of the lab tests take many months (and in some cases up to a year) to settle after delivery,
highlighting what a journey pregnancy is, even after delivery.
highlighting what a journey pregnancy is, even after delivery.
March 27, 2025 at 12:44 PM
Nearly half of the lab tests take many months (and in some cases up to a year) to settle after delivery,
highlighting what a journey pregnancy is, even after delivery.
highlighting what a journey pregnancy is, even after delivery.
Lab tests can be clustered into stereotypical profiles, implying global control principles governing physiological adaptations in pregnancy.
We see strong undershoots and overshoots in many lab tests at delivery, indicating strong compensation mechanisms in action during pregnancy.
We see strong undershoots and overshoots in many lab tests at delivery, indicating strong compensation mechanisms in action during pregnancy.
March 27, 2025 at 12:44 PM
Lab tests can be clustered into stereotypical profiles, implying global control principles governing physiological adaptations in pregnancy.
We see strong undershoots and overshoots in many lab tests at delivery, indicating strong compensation mechanisms in action during pregnancy.
We see strong undershoots and overshoots in many lab tests at delivery, indicating strong compensation mechanisms in action during pregnancy.
and found that only targeting CRH can bypass this adaptation and effectively lower cortisol. (2/2)
Work by @tomermilo.bsky.social
www.embopress.org/doi/full/10....
Work by @tomermilo.bsky.social
www.embopress.org/doi/full/10....
Hormone circuit explains why most HPA drugs fail for mood disorders and predicts the few that work | Molecular Systems Biology
imageimageA mathematical model suggests that existing HPA-targeting drugs failed in clinical
trials for mood disorders because the endocrine glands change their functional mass.
The model predicts CRH...
www.embopress.org
February 4, 2025 at 3:53 PM
and found that only targeting CRH can bypass this adaptation and effectively lower cortisol. (2/2)
Work by @tomermilo.bsky.social
www.embopress.org/doi/full/10....
Work by @tomermilo.bsky.social
www.embopress.org/doi/full/10....