The Twinkle Factory
@twinklefactory.bsky.social
Crazy of fluorescent protein labels, dimerizers, biosensors, etc. The place for #FAST, #splitFAST, #CATCHFIRE, more to come
🔬🌈 first-ever application of #CATCHFIRE to force the tethering of #mitochondria to the microtubule motor KIF17
🥁Out in @natcomms.nature.com
👉Unequal mitochondrial segregation promotes asymmetric fates during neurogenesis
🔗 doi.org/10.1038/s41467-025-66932-0
👏Congratulations to Benjamin Bunel, Xavier Morin, Evelyne Fischer and all authors and collaborators!
👉Unequal mitochondrial segregation promotes asymmetric fates during neurogenesis
🔗 doi.org/10.1038/s41467-025-66932-0
👏Congratulations to Benjamin Bunel, Xavier Morin, Evelyne Fischer and all authors and collaborators!
January 16, 2026 at 2:19 PM
🔬🌈 first-ever application of #CATCHFIRE to force the tethering of #mitochondria to the microtubule motor KIF17
🔬🌈 Première application de #CATCHFIRE ! Dans Le Monde. Suite au papier dans Nature Communications de Benjamin Bunel, Xavier Morin, Evelyne Fischer et al. (@ibensens.bsky.social)
www.lemonde.fr/sciences/art...
www.lemonde.fr/sciences/art...
Découverte du rôle des mitochondries dans la différenciation des cellules en neurones
Grâce à une expérience menée sur la moelle épinière d’embryons de poulet, des biologistes ont constaté lors de la division cellulaire un nombre moins élevé d’organites dans les cellules qui deviendron...
www.lemonde.fr
January 16, 2026 at 2:16 PM
🔬🌈 Première application de #CATCHFIRE ! Dans Le Monde. Suite au papier dans Nature Communications de Benjamin Bunel, Xavier Morin, Evelyne Fischer et al. (@ibensens.bsky.social)
www.lemonde.fr/sciences/art...
www.lemonde.fr/sciences/art...
Reposted by The Twinkle Factory
We introduce #ProxiCapture, an affinity-proteomics platform to map degrader-induced interactions in native cell & tissue lysates. We uncover a context-dependent “glueable” proteome and a scalable route to accelerate molecular glue discovery 🤗
@ibc2-gu.bsky.social @goetheuni.bsky.social
@ibc2-gu.bsky.social @goetheuni.bsky.social
ProxiCapture Reveals Context-Dependent CRBN Interactore Landscape of Molecular Glue Degraders https://www.biorxiv.org/content/10.64898/2026.01.05.697692v1
January 6, 2026 at 8:54 PM
We introduce #ProxiCapture, an affinity-proteomics platform to map degrader-induced interactions in native cell & tissue lysates. We uncover a context-dependent “glueable” proteome and a scalable route to accelerate molecular glue discovery 🤗
@ibc2-gu.bsky.social @goetheuni.bsky.social
@ibc2-gu.bsky.social @goetheuni.bsky.social
A Gold-PROTAC Degrades the Oncogenic Tyrosine Kinase MERTK: Insights into the Degradome from a Steady-State System | ACS Chemical Biology pubs.acs.org/doi/10.1021/...
A Gold-PROTAC Degrades the Oncogenic Tyrosine Kinase MERTK: Insights into the Degradome from a Steady-State System
Proteolysis targeting chimeras (PROTACs) are bifunctional molecules designed to induce the degradation of specific proteins within a cell. While most PROTACs are noncovalent interactors, covalent PROT...
pubs.acs.org
January 7, 2026 at 10:58 AM
🔬🌈 the latest of #CATCHFIRE in bioRxiv
🔬🌈 the authors: "...unique role of the TAD in STAT5
nuclear trafficking, providing new mechanistic insight and potential targets for therapeutic intervention in diseases such as myeloproliferative neoplasms and
leukemia"
doi.org/10.64898/2025.12.11.693681
🔬🌈 the authors: "...unique role of the TAD in STAT5
nuclear trafficking, providing new mechanistic insight and potential targets for therapeutic intervention in diseases such as myeloproliferative neoplasms and
leukemia"
doi.org/10.64898/2025.12.11.693681
December 22, 2025 at 11:25 AM
🔬🌈 the latest of #CATCHFIRE in bioRxiv
🔬🌈 the authors: "...unique role of the TAD in STAT5
nuclear trafficking, providing new mechanistic insight and potential targets for therapeutic intervention in diseases such as myeloproliferative neoplasms and
leukemia"
doi.org/10.64898/2025.12.11.693681
🔬🌈 the authors: "...unique role of the TAD in STAT5
nuclear trafficking, providing new mechanistic insight and potential targets for therapeutic intervention in diseases such as myeloproliferative neoplasms and
leukemia"
doi.org/10.64898/2025.12.11.693681
🔬🌈 #CATCHFIRE now implemented in neurogenesis studies!
🔬🌈 Check www.nature.com/articles/s41467-025-66932-0
🔬🌈 Check www.nature.com/articles/s41467-025-66932-0
December 18, 2025 at 1:26 PM
🔬🌈 #CATCHFIRE now implemented in neurogenesis studies!
🔬🌈 Check www.nature.com/articles/s41467-025-66932-0
🔬🌈 Check www.nature.com/articles/s41467-025-66932-0
🔬🌈 Into #neurogenesis studies?
🔬🌈 Just out in Nature Communications! With #CATCHFIRE, the fluorogenic dimerizer of The Twinkle Factory, the authors were indeed able to force the displacement of mitochondria towards microtubules during mitosis
www.nature.com/articles/s41...
🔬🌈 Just out in Nature Communications! With #CATCHFIRE, the fluorogenic dimerizer of The Twinkle Factory, the authors were indeed able to force the displacement of mitochondria towards microtubules during mitosis
www.nature.com/articles/s41...
Unequal mitochondrial segregation promotes asymmetric fates during neurogenesis - Nature Communications
Bunel et al. show that mitochondria behave as asymmetric fate determinants in vertebrates in vivo. Forcing their unequal segregation during mitosis is sufficient to drive premature neural differentiat...
www.nature.com
December 18, 2025 at 1:22 PM
🔬🌈 Into #neurogenesis studies?
🔬🌈 Just out in Nature Communications! With #CATCHFIRE, the fluorogenic dimerizer of The Twinkle Factory, the authors were indeed able to force the displacement of mitochondria towards microtubules during mitosis
www.nature.com/articles/s41...
🔬🌈 Just out in Nature Communications! With #CATCHFIRE, the fluorogenic dimerizer of The Twinkle Factory, the authors were indeed able to force the displacement of mitochondria towards microtubules during mitosis
www.nature.com/articles/s41...
Reposted by The Twinkle Factory
New biosensor for REDOX lovers! Scientists at VIB, Daria Ezeriņa and Joris Messens, with global partners, developed HyPerFLEX🌈!
@messenslab.bsky.social
@messenslab.bsky.social
October 17, 2025 at 3:11 PM
New biosensor for REDOX lovers! Scientists at VIB, Daria Ezeriņa and Joris Messens, with global partners, developed HyPerFLEX🌈!
@messenslab.bsky.social
@messenslab.bsky.social
🌈 #CATCHFIRE unexpectedly used to track protein excretion by B. subtilis
🌈 in J. Agric. Food Chem. pubs.acs.org/doi/10.1021/acs.jafc.5c05062
🌈 in J. Agric. Food Chem. pubs.acs.org/doi/10.1021/acs.jafc.5c05062
December 5, 2025 at 10:45 PM
🌈 #CATCHFIRE unexpectedly used to track protein excretion by B. subtilis
🌈 in J. Agric. Food Chem. pubs.acs.org/doi/10.1021/acs.jafc.5c05062
🌈 in J. Agric. Food Chem. pubs.acs.org/doi/10.1021/acs.jafc.5c05062
🌈 #CATCHFIRE now applied to force mitochondria displacement during mitosis and drive premature neuronal differentiation
🌈 preprint: www.biorxiv.org/content/10.1101/2024.11.08.622699v2
🌈 preprint: www.biorxiv.org/content/10.1101/2024.11.08.622699v2
December 5, 2025 at 10:30 PM
🌈 #CATCHFIRE now applied to force mitochondria displacement during mitosis and drive premature neuronal differentiation
🌈 preprint: www.biorxiv.org/content/10.1101/2024.11.08.622699v2
🌈 preprint: www.biorxiv.org/content/10.1101/2024.11.08.622699v2
🌈 into H2O2 sensing? Check this paper on HyPerFLEX, an upgrade of the famous Hyper sensor family, combined with #FAST of The Twinkle Factory (@twinklefactory.bsky.social)
🌈 www.nature.com/articles/s41...
🌈 www.nature.com/articles/s41...
A color-tailored fluorogenic sensor for hydrogen peroxide - Nature Chemical Biology
Hydrogen peroxide is a signaling molecule that can also cause damage if its levels are too high. Here, the authors report HyPerFLEX, a fluorescent sensor with tenable colors, to track very low peroxid...
www.nature.com
December 5, 2025 at 7:48 PM
🌈 into H2O2 sensing? Check this paper on HyPerFLEX, an upgrade of the famous Hyper sensor family, combined with #FAST of The Twinkle Factory (@twinklefactory.bsky.social)
🌈 www.nature.com/articles/s41...
🌈 www.nature.com/articles/s41...
🌈 a thorough review on fluorescent biosensors. Thxs!
🌈 many occurrences of FAST and splitFAST of The Twinkle Factory (@twinklefactory.bsky.social)
🌈 many occurrences of FAST and splitFAST of The Twinkle Factory (@twinklefactory.bsky.social)
🚨How do we implement synthetic fluorophores into biosensors? Have a look at Elias Dressler’s review article in Chimia. The issue highlights the work of Young Professors and Ambizione Fellows in Switzerland. Glad to be part of this vibrant community. ⚗️ www.chimia.ch/chimia/artic...
November 28, 2025 at 3:52 PM
🌈 a thorough review on fluorescent biosensors. Thxs!
🌈 many occurrences of FAST and splitFAST of The Twinkle Factory (@twinklefactory.bsky.social)
🌈 many occurrences of FAST and splitFAST of The Twinkle Factory (@twinklefactory.bsky.social)