Tristan Shuman
@tristanshuman.bsky.social
Neuroscientist studying memory, epilepsy, and Alzheimer’s disease.
Associate Professor at Icahn School of Medicine at Mount Sinai
Associate Professor at Icahn School of Medicine at Mount Sinai
Pinned
Tristan Shuman
@tristanshuman.bsky.social
· Sep 11
🚨New preprint alert🚨
We used closed-loop optogenetics to causally test the importance of inhibitory spike timing in network function and found that manipulating PV+ cell theta phase locking in the dentate gyrus can shift seizure susceptibility (both ways!)
We used closed-loop optogenetics to causally test the importance of inhibitory spike timing in network function and found that manipulating PV+ cell theta phase locking in the dentate gyrus can shift seizure susceptibility (both ways!)
Check out new work from our lab! We developed a new way to directly control the precise timing of interneurons during behavior and found that theta phase locking is a causal mediator of seizure susceptibility in both healthy and epileptic mice.
Reposted by Tristan Shuman
Reunion with past and present Cai lab & Shuman lab members (and collaborators). Spending time with you guys is easily the best part of my job.
@tristanshuman.bsky.social
@sinaibrain.bsky.social
@sfn.org
@tristanshuman.bsky.social
@sinaibrain.bsky.social
@sfn.org
November 17, 2025 at 7:31 AM
Reunion with past and present Cai lab & Shuman lab members (and collaborators). Spending time with you guys is easily the best part of my job.
@tristanshuman.bsky.social
@sinaibrain.bsky.social
@sfn.org
@tristanshuman.bsky.social
@sinaibrain.bsky.social
@sfn.org
If you are at SFN this week come to our SFN dance party! Monday night at Parq nightclub. Open to everyone. @denisejcai.bsky.social, Kay Tye, and I are giving out VIP bracelets at SFN all weekend!
November 14, 2025 at 8:07 PM
If you are at SFN this week come to our SFN dance party! Monday night at Parq nightclub. Open to everyone. @denisejcai.bsky.social, Kay Tye, and I are giving out VIP bracelets at SFN all weekend!
Reposted by Tristan Shuman
October 20, 2025 at 2:46 PM
Reposted by Tristan Shuman
Excited to share that I landed my dream job!🎉🎉🎉 The Pennington Lab will be opening at the University of British Columbia in January 2026!
@ubcpsych.bsky.social @dmcbrainhealth.bsky.social
@ubcpsych.bsky.social @dmcbrainhealth.bsky.social
September 29, 2025 at 4:31 PM
Excited to share that I landed my dream job!🎉🎉🎉 The Pennington Lab will be opening at the University of British Columbia in January 2026!
@ubcpsych.bsky.social @dmcbrainhealth.bsky.social
@ubcpsych.bsky.social @dmcbrainhealth.bsky.social
Reposted by Tristan Shuman
We're looking forward to the first annual New York Memory Hub conference later this week! Can't wait for all the talks and discussion about all things learning and memory 🧠
September 22, 2025 at 11:54 AM
We're looking forward to the first annual New York Memory Hub conference later this week! Can't wait for all the talks and discussion about all things learning and memory 🧠
Reposted by Tristan Shuman
🚨New preprint alert🚨
We used closed-loop optogenetics to causally test the importance of inhibitory spike timing in network function and found that manipulating PV+ cell theta phase locking in the dentate gyrus can shift seizure susceptibility (both ways!)
We used closed-loop optogenetics to causally test the importance of inhibitory spike timing in network function and found that manipulating PV+ cell theta phase locking in the dentate gyrus can shift seizure susceptibility (both ways!)
September 11, 2025 at 5:07 PM
🚨New preprint alert🚨
We used closed-loop optogenetics to causally test the importance of inhibitory spike timing in network function and found that manipulating PV+ cell theta phase locking in the dentate gyrus can shift seizure susceptibility (both ways!)
We used closed-loop optogenetics to causally test the importance of inhibitory spike timing in network function and found that manipulating PV+ cell theta phase locking in the dentate gyrus can shift seizure susceptibility (both ways!)
Check out new work from our lab! We developed a new way to directly control the precise timing of interneurons during behavior and found that theta phase locking is a causal mediator of seizure susceptibility in both healthy and epileptic mice.
🚨New preprint alert🚨
We used closed-loop optogenetics to causally test the importance of inhibitory spike timing in network function and found that manipulating PV+ cell theta phase locking in the dentate gyrus can shift seizure susceptibility (both ways!)
We used closed-loop optogenetics to causally test the importance of inhibitory spike timing in network function and found that manipulating PV+ cell theta phase locking in the dentate gyrus can shift seizure susceptibility (both ways!)
September 11, 2025 at 7:13 PM
Check out new work from our lab! We developed a new way to directly control the precise timing of interneurons during behavior and found that theta phase locking is a causal mediator of seizure susceptibility in both healthy and epileptic mice.
Reposted by Tristan Shuman
Check out our latest paper today in Nature: “Goal specific hippocampal inhibition gates learning” www.nature.com/articles/s41...
By Nuri Jeong, Xiao Zheng, Abby Paulson, Steph Prince and colleagues.
By Nuri Jeong, Xiao Zheng, Abby Paulson, Steph Prince and colleagues.
April 9, 2025 at 6:28 PM
Check out our latest paper today in Nature: “Goal specific hippocampal inhibition gates learning” www.nature.com/articles/s41...
By Nuri Jeong, Xiao Zheng, Abby Paulson, Steph Prince and colleagues.
By Nuri Jeong, Xiao Zheng, Abby Paulson, Steph Prince and colleagues.
Reposted by Tristan Shuman
🚨 New lab paper!🚨
A dream study of mine for nearly 20 yrs not possible until now thanks to NIH 🧠 funding & 1st-author lead @seeber.bsky.social
We tracked hippocampal activity as people walked memory-guided paths & imagined them again. Did brain patterns reappear?🧵👇
www.nature.com/articles/s41...
A dream study of mine for nearly 20 yrs not possible until now thanks to NIH 🧠 funding & 1st-author lead @seeber.bsky.social
We tracked hippocampal activity as people walked memory-guided paths & imagined them again. Did brain patterns reappear?🧵👇
www.nature.com/articles/s41...
Human neural dynamics of real-world and imagined navigation - Nature Human Behaviour
Seeber et al. studied brain recordings from implanted electrodes in freely moving humans. Neural dynamics encoded actual and imagined routes similarly, demonstrating parallels between navigational, im...
www.nature.com
March 10, 2025 at 4:52 PM
🚨 New lab paper!🚨
A dream study of mine for nearly 20 yrs not possible until now thanks to NIH 🧠 funding & 1st-author lead @seeber.bsky.social
We tracked hippocampal activity as people walked memory-guided paths & imagined them again. Did brain patterns reappear?🧵👇
www.nature.com/articles/s41...
A dream study of mine for nearly 20 yrs not possible until now thanks to NIH 🧠 funding & 1st-author lead @seeber.bsky.social
We tracked hippocampal activity as people walked memory-guided paths & imagined them again. Did brain patterns reappear?🧵👇
www.nature.com/articles/s41...
Reposted by Tristan Shuman
Grid cells have a geometry in time. Thanks to @azvollan.bsky.social l & @rjgardner.bsky.social for this heroic discovery. @ercresearch.bsky.social
#KiloNeurons @m-bmoser.bsky.social @kavlintnu.bsky.social @nature.com
@kavlifoundation.bsky.social
www.nature.com/articles/s41...
#KiloNeurons @m-bmoser.bsky.social @kavlintnu.bsky.social @nature.com
@kavlifoundation.bsky.social
www.nature.com/articles/s41...
Left–right-alternating theta sweeps in entorhinal–hippocampal maps of space - Nature
A study in rats proposes a mechanism for how the brain maps the surrounding environment, including places it has never seen, by alternating left and right forward sweeps in successive theta cycles.
www.nature.com
February 3, 2025 at 4:18 PM
Grid cells have a geometry in time. Thanks to @azvollan.bsky.social l & @rjgardner.bsky.social for this heroic discovery. @ercresearch.bsky.social
#KiloNeurons @m-bmoser.bsky.social @kavlintnu.bsky.social @nature.com
@kavlifoundation.bsky.social
www.nature.com/articles/s41...
#KiloNeurons @m-bmoser.bsky.social @kavlintnu.bsky.social @nature.com
@kavlifoundation.bsky.social
www.nature.com/articles/s41...
New paper out in Cell Reports! Led by @susieyufeng.bsky.social, we found that chronic epilepsy in mice drives distinct synchronization deficits in hippocampus and MEC, with early changes in HPC and late-onset changes in MEC that align with progressive memory impairment.
www.cell.com/cell-reports...
www.cell.com/cell-reports...
January 28, 2025 at 8:17 PM
New paper out in Cell Reports! Led by @susieyufeng.bsky.social, we found that chronic epilepsy in mice drives distinct synchronization deficits in hippocampus and MEC, with early changes in HPC and late-onset changes in MEC that align with progressive memory impairment.
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Reposted by Tristan Shuman
Interested in how neural communication breaks down in a model of Alzheimer's pathology?
In a new preprint, we found desynchronization in medial entorhinal–hippocampal circuits that coincided with the onset of spatial memory deficits in 3xTg mice. (1/6)
www.biorxiv.org/content/10.1...
In a new preprint, we found desynchronization in medial entorhinal–hippocampal circuits that coincided with the onset of spatial memory deficits in 3xTg mice. (1/6)
www.biorxiv.org/content/10.1...
January 22, 2025 at 4:34 PM
Interested in how neural communication breaks down in a model of Alzheimer's pathology?
In a new preprint, we found desynchronization in medial entorhinal–hippocampal circuits that coincided with the onset of spatial memory deficits in 3xTg mice. (1/6)
www.biorxiv.org/content/10.1...
In a new preprint, we found desynchronization in medial entorhinal–hippocampal circuits that coincided with the onset of spatial memory deficits in 3xTg mice. (1/6)
www.biorxiv.org/content/10.1...
New preprint from the lab!
@laurenmvetere.bsky.social found disrupted MEC-hippocampal synchronization that paralleled the emergence of memory deficits in the 3xTg mouse model of AD pathology!
Check it out and let us know what you think.
@laurenmvetere.bsky.social found disrupted MEC-hippocampal synchronization that paralleled the emergence of memory deficits in the 3xTg mouse model of AD pathology!
Check it out and let us know what you think.
Interested in how neural communication breaks down in a model of Alzheimer's pathology?
In a new preprint, we found desynchronization in medial entorhinal–hippocampal circuits that coincided with the onset of spatial memory deficits in 3xTg mice. (1/6)
www.biorxiv.org/content/10.1...
In a new preprint, we found desynchronization in medial entorhinal–hippocampal circuits that coincided with the onset of spatial memory deficits in 3xTg mice. (1/6)
www.biorxiv.org/content/10.1...
January 22, 2025 at 4:57 PM
New preprint from the lab!
@laurenmvetere.bsky.social found disrupted MEC-hippocampal synchronization that paralleled the emergence of memory deficits in the 3xTg mouse model of AD pathology!
Check it out and let us know what you think.
@laurenmvetere.bsky.social found disrupted MEC-hippocampal synchronization that paralleled the emergence of memory deficits in the 3xTg mouse model of AD pathology!
Check it out and let us know what you think.
Reposted by Tristan Shuman
Did 2024 feel LONG to anyone else? A little 2024 recap from me: I defended my PhD and submitted a first author paper describing my thesis work! Look out for a preprint very soon. (1/6)
January 7, 2025 at 4:00 PM
Did 2024 feel LONG to anyone else? A little 2024 recap from me: I defended my PhD and submitted a first author paper describing my thesis work! Look out for a preprint very soon. (1/6)
Reposted by Tristan Shuman
Hey #ACNP2024!!! I’ve been inspired by y’all to start a new thread to capture the amazing #FashionsOfACNP!
Please add on🙏🏼💃🏻🕺
First up: the one and only @jaredwyoung.bsky.social!
The shoes. The kilt. The vest. Perfection 🧑🍳😘
Please add on🙏🏼💃🏻🕺
First up: the one and only @jaredwyoung.bsky.social!
The shoes. The kilt. The vest. Perfection 🧑🍳😘
December 11, 2024 at 5:59 AM
Hey #ACNP2024!!! I’ve been inspired by y’all to start a new thread to capture the amazing #FashionsOfACNP!
Please add on🙏🏼💃🏻🕺
First up: the one and only @jaredwyoung.bsky.social!
The shoes. The kilt. The vest. Perfection 🧑🍳😘
Please add on🙏🏼💃🏻🕺
First up: the one and only @jaredwyoung.bsky.social!
The shoes. The kilt. The vest. Perfection 🧑🍳😘
Reposted by Tristan Shuman
Thank you to NIH Director Dr. Bertagnolli for sharing our recent work in her latest blog post! I’m so proud of the team and first author @joezaki.bsky.social for all their hard work on these exciting new findings examining stress & memory-linking 🧠
Read here 👇
directorsblog.nih.gov/2024/12/05/s...
Read here 👇
directorsblog.nih.gov/2024/12/05/s...
Study Suggests New Experiences Can Refresh Memories of Past Events, with Implications for Understanding PTSD
Your memories of life experiences are encoded in collections of neurons in the brain that were active at the time the event took place. Later, those same patterns of neural activity are replayed in…
directorsblog.nih.gov
December 5, 2024 at 9:54 PM
Thank you to NIH Director Dr. Bertagnolli for sharing our recent work in her latest blog post! I’m so proud of the team and first author @joezaki.bsky.social for all their hard work on these exciting new findings examining stress & memory-linking 🧠
Read here 👇
directorsblog.nih.gov/2024/12/05/s...
Read here 👇
directorsblog.nih.gov/2024/12/05/s...
Reposted by Tristan Shuman
SO EXCITED to share our latest work demonstrating that the anterior hypothalamic nucleus (AHN) regulates stress vulnerability!!!
❓ Do you know what the anterior hypothalamic nucleus (AHN) does? No? Neither did we! 🧠
In a new preprint from the Cai Lab, learn how we discovered the AHN’s central role in regulating stress vulnerability.
Read the paper here: www.biorxiv.org/content/10.1... (1/6)
In a new preprint from the Cai Lab, learn how we discovered the AHN’s central role in regulating stress vulnerability.
Read the paper here: www.biorxiv.org/content/10.1... (1/6)
November 22, 2024 at 8:16 PM
SO EXCITED to share our latest work demonstrating that the anterior hypothalamic nucleus (AHN) regulates stress vulnerability!!!
This is going to be a great conference! Excited to join!
Registration & Abstract Submission is open for the 2025 "Engram and Ensembles in Learning and Memory" meeting, at Trinity College Dublin in May.
Abstract deadline February 14.
#EngramsandEnsembles2025
Preliminary Agenda at event website:
event.fourwaves.com/engramsensem...
Abstract deadline February 14.
#EngramsandEnsembles2025
Preliminary Agenda at event website:
event.fourwaves.com/engramsensem...
November 22, 2024 at 5:01 PM
This is going to be a great conference! Excited to join!
Reposted by Tristan Shuman
A thread on NIH Reorganization and the Scientific Management Review Board (SMRB)
Disclosure: I was involved with the SMRB since its inception and have very strong feelings about how it was used, misused, and abandoned. My passion on these issues will undoubtably show through.
1/n
Disclosure: I was involved with the SMRB since its inception and have very strong feelings about how it was used, misused, and abandoned. My passion on these issues will undoubtably show through.
1/n
November 20, 2024 at 12:39 PM
A thread on NIH Reorganization and the Scientific Management Review Board (SMRB)
Disclosure: I was involved with the SMRB since its inception and have very strong feelings about how it was used, misused, and abandoned. My passion on these issues will undoubtably show through.
1/n
Disclosure: I was involved with the SMRB since its inception and have very strong feelings about how it was used, misused, and abandoned. My passion on these issues will undoubtably show through.
1/n
Reposted by Tristan Shuman
🌟 Cai Lab Nature (@natureportfolio.bsky.social) paper alert! In work led by Joe Zaki, we find that rest periods after learning not only stabilize new memories BUT ALSO integrate new memories with older ones from days past! (1/10)
Read it here: www.nature.com/articles/s41...
Read it here: www.nature.com/articles/s41...
November 19, 2024 at 4:50 PM
🌟 Cai Lab Nature (@natureportfolio.bsky.social) paper alert! In work led by Joe Zaki, we find that rest periods after learning not only stabilize new memories BUT ALSO integrate new memories with older ones from days past! (1/10)
Read it here: www.nature.com/articles/s41...
Read it here: www.nature.com/articles/s41...
Reposted by Tristan Shuman
xcited to share our new results! We (huge team effort led by post-doc extraordinaire Sylvie Lesuis) examined the effects of acute stress on threat memory generalization and engram ensemble architecture.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Stress disrupts engram ensembles in lateral amygdala to generalize threat memory in mice
Stress induces aversive memory overgeneralization, a hallmark of many psychiatric disorders. Memories are encoded by a sparse ensemble of neurons acti…
www.sciencedirect.com
November 15, 2024 at 4:37 PM
xcited to share our new results! We (huge team effort led by post-doc extraordinaire Sylvie Lesuis) examined the effects of acute stress on threat memory generalization and engram ensemble architecture.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Come work with us at Mount Sinai! We have an open search for tenure-track faculty in the Department of Neuroscience focusing on Computational and Systems Neuroscience. Feel free to reach out to me with questions.
neuroscience.mssm.edu/docs/Faculty...
Initial review will begin next week!
neuroscience.mssm.edu/docs/Faculty...
Initial review will begin next week!
November 13, 2024 at 11:17 PM
Come work with us at Mount Sinai! We have an open search for tenure-track faculty in the Department of Neuroscience focusing on Computational and Systems Neuroscience. Feel free to reach out to me with questions.
neuroscience.mssm.edu/docs/Faculty...
Initial review will begin next week!
neuroscience.mssm.edu/docs/Faculty...
Initial review will begin next week!
Reposted by Tristan Shuman
go.bsky.app/LdtUYZS
I created a starter pack for the growing community of hippocampus physiologists that have joined the great migration. Also included the physiology-adjacent.
Tell me who I haven’t found yet
I created a starter pack for the growing community of hippocampus physiologists that have joined the great migration. Also included the physiology-adjacent.
Tell me who I haven’t found yet
November 12, 2024 at 9:00 PM
go.bsky.app/LdtUYZS
I created a starter pack for the growing community of hippocampus physiologists that have joined the great migration. Also included the physiology-adjacent.
Tell me who I haven’t found yet
I created a starter pack for the growing community of hippocampus physiologists that have joined the great migration. Also included the physiology-adjacent.
Tell me who I haven’t found yet
Reposted by Tristan Shuman
Open faculty search at Mount Sinai in Computational and/or Systems Neuroscience. Deadline is November 15th, 2024
neuroscience.mssm.edu/pdf/faculty-...
neuroscience.mssm.edu/pdf/faculty-...
November 4, 2024 at 7:20 PM
Open faculty search at Mount Sinai in Computational and/or Systems Neuroscience. Deadline is November 15th, 2024
neuroscience.mssm.edu/pdf/faculty-...
neuroscience.mssm.edu/pdf/faculty-...