@tomas-p.bsky.social
Post-doc researcher at CQSB-SU-París
#yeast #genomics
#yeast #genomics
Reposted
One of the most exciting works of my career, years in the making. We used high-throughput precision genome editing to test the fitness effects of thousands of natural variants. Our findings challenge the long-held assumption that common variants are inconsequential.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Massively parallel interrogation of the fitness of natural variants in ancient signaling pathways reveals pervasive local adaptation
The nature of standing genetic variation remains a central debate in population genetics, with differing perspectives on whether common variants are almost always neutral as suggested by neutral and n...
www.biorxiv.org
October 22, 2025 at 5:46 PM
One of the most exciting works of my career, years in the making. We used high-throughput precision genome editing to test the fitness effects of thousands of natural variants. Our findings challenge the long-held assumption that common variants are inconsequential.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted
The SMBE Satellite Meeting in Puerto Varas, Chile, was a resounding success!
The meeting brought together >70 researchers from different continents for 3 days of inspiring science, vibrant discussion, and genuine community building.
Congratulations to the organization!
@smbe-chile2025.bsky.social
The meeting brought together >70 researchers from different continents for 3 days of inspiring science, vibrant discussion, and genuine community building.
Congratulations to the organization!
@smbe-chile2025.bsky.social
October 15, 2025 at 3:50 PM
The SMBE Satellite Meeting in Puerto Varas, Chile, was a resounding success!
The meeting brought together >70 researchers from different continents for 3 days of inspiring science, vibrant discussion, and genuine community building.
Congratulations to the organization!
@smbe-chile2025.bsky.social
The meeting brought together >70 researchers from different continents for 3 days of inspiring science, vibrant discussion, and genuine community building.
Congratulations to the organization!
@smbe-chile2025.bsky.social
Reposted
✨ Latest exciting story of the group in @nature.com. Here, we go beyond SNPs and built a species-wide atlas of genetic variants in yeast. With >1,000 near T2T genomes, we show how large genomic variations affect trait diversity.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
From genotype to phenotype with 1,086 near telomere-to-telomere yeast genomes - Nature
A newly compiled atlas of species-wide structural variants and gene-based and graph pangenomes derived from highly complete assemblies of genomes from 1,086 natural isolates enable integrative genome-...
www.nature.com
October 16, 2025 at 7:49 AM
✨ Latest exciting story of the group in @nature.com. Here, we go beyond SNPs and built a species-wide atlas of genetic variants in yeast. With >1,000 near T2T genomes, we show how large genomic variations affect trait diversity.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted
🔎 Robyn Shaw shares key insights from a global meta-analysis: Within-population genetic diversity is declining on timescales shaped by human activity, but #conservation can help mitigate the loss.
🔗 www.nature.com/articles/s41... @coalitioncongen.bsky.social @robynshaw.bsky.social
🔗 www.nature.com/articles/s41... @coalitioncongen.bsky.social @robynshaw.bsky.social
Global meta-analysis shows action is needed to halt genetic diversity loss - Nature
A comprehensive meta-analysis of global terrestrial and marine genetic diversity covering more than three decades of research demonstrates rapid loss of genetic diversity and identifies conservation interventions that could mitigate this process.
www.nature.com
October 1, 2025 at 9:16 AM
🔎 Robyn Shaw shares key insights from a global meta-analysis: Within-population genetic diversity is declining on timescales shaped by human activity, but #conservation can help mitigate the loss.
🔗 www.nature.com/articles/s41... @coalitioncongen.bsky.social @robynshaw.bsky.social
🔗 www.nature.com/articles/s41... @coalitioncongen.bsky.social @robynshaw.bsky.social
Reposted
🚀 ¿Buscas una oportunidad postdoctoral en biotecnología fúngica, evolución o IA aplicada a datos multiómicos?
En FunGIALab (IATA-CSIC, Valencia) buscamos candidat@s para #JuanDeLaCierva, #MSCA y más.
🌍 Entorno internacional, proyectos punteros y gran ambiente.
📄 Info disponible aquí: bit.ly/4nZm9wC
En FunGIALab (IATA-CSIC, Valencia) buscamos candidat@s para #JuanDeLaCierva, #MSCA y más.
🌍 Entorno internacional, proyectos punteros y gran ambiente.
📄 Info disponible aquí: bit.ly/4nZm9wC
Job offers
SACO - Servicio de Almacenamiento Compartido de la Organización - SGAI - CSIC
bit.ly
October 3, 2025 at 9:09 AM
🚀 ¿Buscas una oportunidad postdoctoral en biotecnología fúngica, evolución o IA aplicada a datos multiómicos?
En FunGIALab (IATA-CSIC, Valencia) buscamos candidat@s para #JuanDeLaCierva, #MSCA y más.
🌍 Entorno internacional, proyectos punteros y gran ambiente.
📄 Info disponible aquí: bit.ly/4nZm9wC
En FunGIALab (IATA-CSIC, Valencia) buscamos candidat@s para #JuanDeLaCierva, #MSCA y más.
🌍 Entorno internacional, proyectos punteros y gran ambiente.
📄 Info disponible aquí: bit.ly/4nZm9wC
Reposted
Allelic variation in MAL33 drives ecological adaptation of maltose metabolism in Saccharomyces eubayanus https://www.biorxiv.org/content/10.1101/2025.09.15.676268v1
September 19, 2025 at 2:33 PM
Allelic variation in MAL33 drives ecological adaptation of maltose metabolism in Saccharomyces eubayanus https://www.biorxiv.org/content/10.1101/2025.09.15.676268v1
Reposted
New preprint from the lab: we show that the ability to switch mating type was lost at least 13 times independently in the evolution of S. cerevisiae. At least 27% of isolates are heterothallic with a strong association with polyploidy and heterozygosity
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Repeated losses of self-fertility shaped heterozygosity and polyploidy in yeast evolution
Evolutionary transitions in mating strategy have profound consequences for genetic variation and adaptation. In Saccharomyces cerevisiae, mating-type switching is a central feature of the life cycle t...
www.biorxiv.org
September 16, 2025 at 6:42 PM
New preprint from the lab: we show that the ability to switch mating type was lost at least 13 times independently in the evolution of S. cerevisiae. At least 27% of isolates are heterothallic with a strong association with polyploidy and heterozygosity
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted
We are very happy to announce that #Yeast is launching a new special issue on the International Yeast Meetings of 2025: #ICYGMB32, #pombe2025 and #ISSY38. The deadline for abstract submission is 30th September 2025. Hurry up!!!
More info in the thread below.
onlinelibrary.wiley.com/page/journal...
More info in the thread below.
onlinelibrary.wiley.com/page/journal...
Yeast Call for Papers: International Yeasts Meetings of 2025
Yeast is a microbiology journal for research in the rapidly moving field of yeast biology. We publish the most significant developments in unicellular fungi.
onlinelibrary.wiley.com
September 8, 2025 at 5:20 PM
We are very happy to announce that #Yeast is launching a new special issue on the International Yeast Meetings of 2025: #ICYGMB32, #pombe2025 and #ISSY38. The deadline for abstract submission is 30th September 2025. Hurry up!!!
More info in the thread below.
onlinelibrary.wiley.com/page/journal...
More info in the thread below.
onlinelibrary.wiley.com/page/journal...
Reposted
We often talk about THE whole genome duplication in yeasts, but we find new evidence of additional whole genome duplications in other yeast species!
Check out this preprint led by @kylethedavid.bsky.social www.biorxiv.org/content/10.1...
Check out this preprint led by @kylethedavid.bsky.social www.biorxiv.org/content/10.1...
Discovery of additional ancient genome duplications in yeasts
Whole genome duplication (WGD) has had profound macroevolutionary impacts on diverse lineages, preceding adaptive radiations in vertebrates, teleost fish, and angiosperms. In contrast to the many know...
www.biorxiv.org
September 5, 2025 at 8:05 PM
We often talk about THE whole genome duplication in yeasts, but we find new evidence of additional whole genome duplications in other yeast species!
Check out this preprint led by @kylethedavid.bsky.social www.biorxiv.org/content/10.1...
Check out this preprint led by @kylethedavid.bsky.social www.biorxiv.org/content/10.1...
Reposted
Should more microbiologists be running long-term evolution experiments? It isn't just me who thinks so :>)
dynamicecology.wordpress.com/2025/09/02/b...
dynamicecology.wordpress.com/2025/09/02/b...
September 3, 2025 at 3:39 AM
Should more microbiologists be running long-term evolution experiments? It isn't just me who thinks so :>)
dynamicecology.wordpress.com/2025/09/02/b...
dynamicecology.wordpress.com/2025/09/02/b...
Reposted
Delighted to see @sakshikhaiwal.bsky.social work in print www.embopress.org/doi/full/10....
Huge thank to @univcotedazur.bsky.social for providing extensive support on this project, @pedrobeltrao.bsky.social and Jonas groups for huge help, @cnrs.fr @ircan.bsky.social
Huge thank to @univcotedazur.bsky.social for providing extensive support on this project, @pedrobeltrao.bsky.social and Jonas groups for huge help, @cnrs.fr @ircan.bsky.social
Predicting natural variation in the yeast phenotypic landscape with machine learning | Molecular Systems Biology
imageimageAn ensemble of phenotypes measured in the genome-sequenced 1,011 S. cerevisiae collection were coupled with genomics and molecular-level data to benchmark machine learning models for quantitative phenotypic predictions at scale. Large-...
www.embopress.org
September 1, 2025 at 9:13 AM
Delighted to see @sakshikhaiwal.bsky.social work in print www.embopress.org/doi/full/10....
Huge thank to @univcotedazur.bsky.social for providing extensive support on this project, @pedrobeltrao.bsky.social and Jonas groups for huge help, @cnrs.fr @ircan.bsky.social
Huge thank to @univcotedazur.bsky.social for providing extensive support on this project, @pedrobeltrao.bsky.social and Jonas groups for huge help, @cnrs.fr @ircan.bsky.social
Reposted
Accurate, scalable structural variant genotyping in complex genomes at population scales. #VariantGenotyping #StructuralVariants #PopulationScale #Genomics #Bioinformatics @molbioevol.bsky.social 🧬 🖥️
academic.oup.com/mbe/advance-...
academic.oup.com/mbe/advance-...
August 10, 2025 at 7:32 AM
Accurate, scalable structural variant genotyping in complex genomes at population scales. #VariantGenotyping #StructuralVariants #PopulationScale #Genomics #Bioinformatics @molbioevol.bsky.social 🧬 🖥️
academic.oup.com/mbe/advance-...
academic.oup.com/mbe/advance-...
Reposted
Nature spoke to five early-career researchers who began their PhDs during the early days of the COVID-19 pandemic and are now planning their next steps as they graduate. #Academicsky 🧪
Class of 2025: five PhD students reveal realigned priorities in wake of COVID and cuts
Scientists who began their doctoral studies in 2020 found their feet during a global pandemic and are graduating into an uncertain and chaotic future.
go.nature.com
July 27, 2025 at 1:20 PM
Nature spoke to five early-career researchers who began their PhDs during the early days of the COVID-19 pandemic and are now planning their next steps as they graduate. #Academicsky 🧪
July 25, 2025 at 1:32 PM
Reposted
For all attending the SMBE Satellite Meeting in Puerto Varas, Chile, on Molecular Mechanisms of Adaptation and Experimental Evolution, please remember to register before the deadline on July 31st.
📝 July 31, 2025
📅 October 6-8, 2025
🔗 smbechile2025.cl
📝 July 31, 2025
📅 October 6-8, 2025
🔗 smbechile2025.cl
July 25, 2025 at 12:01 PM
For all attending the SMBE Satellite Meeting in Puerto Varas, Chile, on Molecular Mechanisms of Adaptation and Experimental Evolution, please remember to register before the deadline on July 31st.
📝 July 31, 2025
📅 October 6-8, 2025
🔗 smbechile2025.cl
📝 July 31, 2025
📅 October 6-8, 2025
🔗 smbechile2025.cl
Reposted
Starting off Bluesky with a highlight! Proud to share our latest review in Current Biology on Yeast Domestication.
🔗https://doi.org/10.1016/j.cub.2025.04.056
🔗https://doi.org/10.1016/j.cub.2025.04.056
July 11, 2025 at 1:28 PM
Starting off Bluesky with a highlight! Proud to share our latest review in Current Biology on Yeast Domestication.
🔗https://doi.org/10.1016/j.cub.2025.04.056
🔗https://doi.org/10.1016/j.cub.2025.04.056
Reposted
We have an opening for postdoctoral training! Please apply by 15th August 2025 for full consideration. Here is the ad: hittinger.genetics.wisc.edu/People/Join/...
hittinger.genetics.wisc.edu
July 10, 2025 at 9:50 PM
We have an opening for postdoctoral training! Please apply by 15th August 2025 for full consideration. Here is the ad: hittinger.genetics.wisc.edu/People/Join/...
Reposted
In another fruitful collaboration with the @rokaslab.bsky.social, Hittinger Lab members @katarina-aranguiz.bsky.social and @linder-surprise.bsky.social , et al. established a ML framework to identify gene families in the yeast subphylum Saccharomycotina whose copy numbers predicted ROS resistance.
Machine learning reveals genes impacting oxidative stress resistance across yeasts - Nature Communications
Yeasts are exposed to oxidative stress during routine metabolism, bioproduction, and interactions with other organisms. Here, the authors use a machine learning classifier to identify genes that are p...
www.nature.com
July 9, 2025 at 8:07 PM
In another fruitful collaboration with the @rokaslab.bsky.social, Hittinger Lab members @katarina-aranguiz.bsky.social and @linder-surprise.bsky.social , et al. established a ML framework to identify gene families in the yeast subphylum Saccharomycotina whose copy numbers predicted ROS resistance.
Reposted
The latest story from the @haploteam highlights the phenotypic impact of acquired subgenomes in allopolyploids, through the lens of 1,060 Brettanomyces bruxellensis genomes. Nice collaboration with @univbordeaux.bsky.social
@unistra.fr @cnrsbiologie.bsky.social
www.nature.com/articles/s41...
@unistra.fr @cnrsbiologie.bsky.social
www.nature.com/articles/s41...
Whole-genome sequencing of 1,060 Brettanomyces bruxellensis isolates reveals significant phenotypic impact of acquired subgenomes in allopolyploids - Nature Communications
The authors sequence and phenotype over 1,000 isolates of the yeast Brettanomyces bruxellensis, and show how allopolyploidization reshapes genome evolution and enhances phenotypic diversity, highlight...
www.nature.com
July 3, 2025 at 7:08 PM
The latest story from the @haploteam highlights the phenotypic impact of acquired subgenomes in allopolyploids, through the lens of 1,060 Brettanomyces bruxellensis genomes. Nice collaboration with @univbordeaux.bsky.social
@unistra.fr @cnrsbiologie.bsky.social
www.nature.com/articles/s41...
@unistra.fr @cnrsbiologie.bsky.social
www.nature.com/articles/s41...
Reposted
Job alert! We have a postdoc position available in the Stelkens Lab at Stockholm University. Join us and apply experimental evolution and comparative genomics in the model system yeast to test for parallel climate adaptation. Apply through this link: su.varbi.com/en/what:job/... Deadline 15 August.
June 30, 2025 at 1:32 PM
Job alert! We have a postdoc position available in the Stelkens Lab at Stockholm University. Join us and apply experimental evolution and comparative genomics in the model system yeast to test for parallel climate adaptation. Apply through this link: su.varbi.com/en/what:job/... Deadline 15 August.
🇨🇱
The Milky Way during a lunar eclipse, a deep-sea ecosystem, and wildfire smoke are among May’s best science images, as selected by Nature’s photo team. 🔭 🧪
See the Milky Way dazzle during a lunar eclipse — May’s best science images
The month’s sharpest science shots, selected by Nature’s photo team.
go.nature.com
June 2, 2025 at 4:29 PM
🇨🇱
Reposted
One of our main sponsors, the Knut and Alice Wallenberg Foundation, has published a nice article about our work. Yay to fundamental research! @kawresearch.bsky.social kaw.wallenberg.org/en/research/...
Wild yeasts as a model for climate research | Knut and Alice Wallenberg Foundation
Wild yeasts live in the forests all around us. Yet, little is known about the role they play in ecosystems. They can be used to develop new beer and bread flavors, but wild yeast can also serve as a u...
kaw.wallenberg.org
May 9, 2025 at 10:25 AM
One of our main sponsors, the Knut and Alice Wallenberg Foundation, has published a nice article about our work. Yay to fundamental research! @kawresearch.bsky.social kaw.wallenberg.org/en/research/...
Reposted
📢 3 Postdoc positions available in @evomicslab.bsky.social
targeting on genome instability evolution of both yeast and human genomes. Both computational genomics and experimental genomics backgrounds are welcome! 🧬🧑💻🧪 For more information, see evomicslab.org or send me a message!
targeting on genome instability evolution of both yeast and human genomes. Both computational genomics and experimental genomics backgrounds are welcome! 🧬🧑💻🧪 For more information, see evomicslab.org or send me a message!
Evomics Lab – Exploring Omics in the Light of Evolution
evomicslab.org
April 28, 2025 at 6:17 AM
📢 3 Postdoc positions available in @evomicslab.bsky.social
targeting on genome instability evolution of both yeast and human genomes. Both computational genomics and experimental genomics backgrounds are welcome! 🧬🧑💻🧪 For more information, see evomicslab.org or send me a message!
targeting on genome instability evolution of both yeast and human genomes. Both computational genomics and experimental genomics backgrounds are welcome! 🧬🧑💻🧪 For more information, see evomicslab.org or send me a message!
Reposted
Excited to share the first manuscript from my PhD in which we leveraged ultra-long Nanopore sequencing, D. melanogaster inbred lines, and a ton of manual validation to investigate the effects of long-read length on population-level structural variant (SV) calling accuracy! doi.org/10.1101/2025...
Manual validation finds only ultra-long long-read sequencing enables faithful, population-level structural variant calling in Drosophila melanogaster euchromatin
The increasing accessibility of long-read sequencing and the rapid development of automated variant callers are promoting the generation of population-level structural variation data. However, the eff...
doi.org
April 25, 2025 at 8:03 PM
Excited to share the first manuscript from my PhD in which we leveraged ultra-long Nanopore sequencing, D. melanogaster inbred lines, and a ton of manual validation to investigate the effects of long-read length on population-level structural variant (SV) calling accuracy! doi.org/10.1101/2025...
Reposted
Unexplored Yeast diversity in Seed Microbiota
Full text: www.biorxiv.org/content/10.1...
#yeast #microbiology #saccharomyces
Full text: www.biorxiv.org/content/10.1...
#yeast #microbiology #saccharomyces
March 27, 2025 at 6:32 PM
Unexplored Yeast diversity in Seed Microbiota
Full text: www.biorxiv.org/content/10.1...
#yeast #microbiology #saccharomyces
Full text: www.biorxiv.org/content/10.1...
#yeast #microbiology #saccharomyces