Todd Lencz
@toddlencz.bsky.social
Genetics, Psychiatry, Polygenic Risk Scores, Embryo Screening... https://feinstein.northwell.edu/institutes-researchers/our-researchers/todd-lencz-phd
See my pinned tweet for more details
October 20, 2025 at 4:43 PM
See my pinned tweet for more details
Given that we are unlikely to scale much beyond this enormous dataset anytime soon, this appears to be quite a negative result…
August 22, 2025 at 8:12 PM
Given that we are unlikely to scale much beyond this enormous dataset anytime soon, this appears to be quite a negative result…
Congratulations, Sunny—All the more impressive given the current environment. Your work is truly at the cutting edge!
July 24, 2025 at 7:30 PM
Congratulations, Sunny—All the more impressive given the current environment. Your work is truly at the cutting edge!
This looks fascinating - I can’t wait to read it in detail.
I am wondering if your approach resembles something we tried on a much smaller scale a few years ago: pubmed.ncbi.nlm.nih.gov/32956347/
I am wondering if your approach resembles something we tried on a much smaller scale a few years ago: pubmed.ncbi.nlm.nih.gov/32956347/
Leveraging correlations between variants in polygenic risk scores to detect heterogeneity in GWAS cohorts - PubMed
Evidence from both GWAS and clinical observation has suggested that certain psychiatric, metabolic, and autoimmune diseases are heterogeneous, comprising multiple subtypes with distinct genomic etiolo...
pubmed.ncbi.nlm.nih.gov
July 24, 2025 at 5:43 PM
This looks fascinating - I can’t wait to read it in detail.
I am wondering if your approach resembles something we tried on a much smaller scale a few years ago: pubmed.ncbi.nlm.nih.gov/32956347/
I am wondering if your approach resembles something we tried on a much smaller scale a few years ago: pubmed.ncbi.nlm.nih.gov/32956347/
Need to double-check but I think it could be design / MAF cut-offs for each type of study
June 14, 2025 at 5:50 PM
Need to double-check but I think it could be design / MAF cut-offs for each type of study
More details at the link:
t.co/ThiWw7QdkU
t.co/ThiWw7QdkU
https://www.biologicalpsychiatryjournal.com/article/S0006-3223(25)00989-8/fulltext
t.co
May 14, 2025 at 2:13 PM
More details at the link:
t.co/ThiWw7QdkU
t.co/ThiWw7QdkU
Concordant SNPs (low cognition / increased SZ risk) were associated with early neurodevelopmental (prenatal) forebrain abnormalities. Discordant SNPs (high cognition / increased SZ risk) associated with adult synaptic function and hindbrain (cerebellar) development. (2/3)
May 14, 2025 at 2:13 PM
Concordant SNPs (low cognition / increased SZ risk) were associated with early neurodevelopmental (prenatal) forebrain abnormalities. Discordant SNPs (high cognition / increased SZ risk) associated with adult synaptic function and hindbrain (cerebellar) development. (2/3)
💯 always take the reader by the hand and walk them through slowly paragraph by paragraph
May 8, 2025 at 3:46 AM
💯 always take the reader by the hand and walk them through slowly paragraph by paragraph
We identified 113 Bonferroni-corrected putatively causal associations (46 novel) involving 91 proteins, providing support for repurposing of anti-inflammatory agents for SCZ, amantadine for BD, retinoic acid for MDD, and duloxetine for CTP.
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Circulating Blood-Based Proteins in Psychopathology and Cognition
This mendelian randomization study identifies circulating proteins associated with risk for schizophrenia, bipolar disorder, major depressive disorder, and cognitive task performance.
jamanetwork.com
March 12, 2025 at 6:54 PM
We identified 113 Bonferroni-corrected putatively causal associations (46 novel) involving 91 proteins, providing support for repurposing of anti-inflammatory agents for SCZ, amantadine for BD, retinoic acid for MDD, and duloxetine for CTP.
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
But then you run right into DISC1
March 10, 2025 at 7:34 AM
But then you run right into DISC1
We have a position open in my lab. Please see my pinned post!
March 9, 2025 at 4:08 AM
We have a position open in my lab. Please see my pinned post!
I'm hiring a postdoc and/or bioinformatician in
psychiatric genomics and related fields
acnp.org/wp-content/u...
psychiatric genomics and related fields
acnp.org/wp-content/u...
acnp.org
February 15, 2025 at 7:02 PM
I'm hiring a postdoc and/or bioinformatician in
psychiatric genomics and related fields
acnp.org/wp-content/u...
psychiatric genomics and related fields
acnp.org/wp-content/u...
For me, the simplicity and ease of both upload and download are the best parts or bioRxiv and medRxiv. (Bravo, Richard!)
If anything, I notice that the site sometimes hangs despite the simplicity of the interface, suggesting that the network is already loaded to capacity.
If anything, I notice that the site sometimes hangs despite the simplicity of the interface, suggesting that the network is already loaded to capacity.
December 22, 2024 at 8:05 PM
For me, the simplicity and ease of both upload and download are the best parts or bioRxiv and medRxiv. (Bravo, Richard!)
If anything, I notice that the site sometimes hangs despite the simplicity of the interface, suggesting that the network is already loaded to capacity.
If anything, I notice that the site sometimes hangs despite the simplicity of the interface, suggesting that the network is already loaded to capacity.
I’m recruiting for a postdoc position in psychiatric genetics
Come talk to me at poster M160!
acnp.org/wp-content/u...
Come talk to me at poster M160!
acnp.org/wp-content/u...
acnp.org
December 9, 2024 at 5:59 PM
I’m recruiting for a postdoc position in psychiatric genetics
Come talk to me at poster M160!
acnp.org/wp-content/u...
Come talk to me at poster M160!
acnp.org/wp-content/u...
very cool! cc: @kgjonas.bsky.social
November 26, 2024 at 5:02 PM
very cool! cc: @kgjonas.bsky.social