Our 3D study of the tumor microenvironment is finally out!

Play around with the data yourself at lung-3d-browser.mdc-berlin.de (Kudos to @danilexn.bsky.social👏 )

Many thanks to Nikolaus Rajewsky lab at @mdc-bimsb.bsky.social and everyone involved, it takes a village to raise a multimodal paper!

4/ Several challenges exist to their swift clincal translation: What is the ‘best’ ST method? How do we turn complex molecular data into meaningful insights for patient care? How do we integrate in clinical routines?

3/ In the clinic, spatial biomarkers and patient-specific molecular mechanisms identified by ST hold great potential to inform patient care and help the discovery of novel drug targets, as showcased in early preclinical studies

2/ With high-resolution ST we can study tissue organization in 2D and 3D virtual tissue blocks, analyzing the organization of cells in multicellular niches and identifying which receptor–ligand interactions orchestrate their function in situ.

1/ High-resolution ST omics work as molecular microscopes, digitalizing gene expression and tissue morphology at subcellular resolution. This enables the interactive exploration of millions of transcripts and their comparison with routine histology and pathologist annotations.