Tony Martini
tmartini.bsky.social
Tony Martini
@tmartini.bsky.social
Regular Human Microbiologist | Bacterial Physiology & Pathogenesis | Polymicrobial Infection Models w/ S. aureus, P. aeruginosa, S. sanguinis, and more | Postdoc @ NIH, Khare Lab | Board Games & TRPGs | Tennis | Metalhead | Seinfeld
Particular thanks are due to @anukharelab.bsky.social
for her mentorship and support throughout the project, @saraalexander.bsky.social for getting everything started, and everyone else in the lab for their support and feedback.
July 5, 2024 at 3:29 PM
...from pyocyanin, suggesting that loss of CodY activity facilitates protection via a multifaceted transcriptional response. We think this contributes to understanding how bacteria can adapt to interspecies antagonism, thus improving or maintaining fitness in polymicrobial environments.
July 5, 2024 at 3:28 PM
...mutant in response to PYO that i) rapidly suppressed metabolism and ii) enhanced expression of stress response genes, particularly catalase. Experimentally, chemical inhibition of metabolism and overexpression of catalase in our parental strain were both sufficient to provide protection...
July 5, 2024 at 3:28 PM
...the supremely talented @saraalexander.bsky.social, who evolved these adapted strains and identified loss-of-function mutations in CodY, a global transcriptional regulator, as responsible for increased S. aureus survival in PYO. Subsequently, we defined transcriptional changes in the CodY...
July 5, 2024 at 3:27 PM