Charlotte Capitanchik
@tinycaptain.bsky.social
RNA Bioinformatics Postdoc at Crick Institute/ UK DRI @ King's College London w/ Jernej Ule (@ulelab) and Ben Blencowe | Co-founder of Londonomics Network | Co-creator of Flow.Bio
Reposted by Charlotte Capitanchik
Former OpenAI product safety leader sounding a loud warning about artificial intimacy. www.nytimes.com/2025/10/28/o...
Opinion | I Led Product Safety at OpenAI. Don’t Trust Its Claims About ‘Erotica.’
www.nytimes.com
November 14, 2025 at 6:15 AM
Former OpenAI product safety leader sounding a loud warning about artificial intimacy. www.nytimes.com/2025/10/28/o...
www.cnn.com/2025/11/06/u... absolutely sickening, such a painful read. LLMs could be powerful tools for science, but should never have been trained to interact with people like it is a friend. In a loneliness pandemic can you really expect people to resist this emotional junk food?
ChatGPT encouraged college graduate to commit suicide, family claims in lawsuit against OpenAI | CNN
A 23-year-old man killed himself in Texas after ChatGPT ‘goaded’ him to commit suicide, his family says in a lawsuit.
www.cnn.com
November 7, 2025 at 10:07 PM
www.cnn.com/2025/11/06/u... absolutely sickening, such a painful read. LLMs could be powerful tools for science, but should never have been trained to interact with people like it is a friend. In a loneliness pandemic can you really expect people to resist this emotional junk food?
Reposted by Charlotte Capitanchik
If I had to do a second PhD it would for sure be this one! So exciting!
🚨 Applications to the Crick PhD programme are now open!
We are pleased to be recruiting this year. 👇
www.crick.ac.uk/careers-stud...
We are pleased to be recruiting this year. 👇
www.crick.ac.uk/careers-stud...
Findlay Lab | Developing novel genome editing methods to test human genetic variants at scale
www.crick.ac.uk
October 1, 2025 at 12:48 PM
If I had to do a second PhD it would for sure be this one! So exciting!
Reposted by Charlotte Capitanchik
So cool they discovered the cause of autism on basically day they guessed they would. I’m also glad they are withholding this information for a few days to prep for a WrestleMania-style announcement. This is how science works.
September 22, 2025 at 6:46 PM
So cool they discovered the cause of autism on basically day they guessed they would. I’m also glad they are withholding this information for a few days to prep for a WrestleMania-style announcement. This is how science works.
Like & share our new promo vid for Flow.bio! Capturing just a little bit of that bioinformatics trauma 🫠 www.youtube.com/watch?v=MR-R...
Flow
Flow.bio
September 22, 2025 at 1:36 PM
Like & share our new promo vid for Flow.bio! Capturing just a little bit of that bioinformatics trauma 🫠 www.youtube.com/watch?v=MR-R...
Reposted by Charlotte Capitanchik
Acetaminophen/paracetamol use in pregnancy doesn't cause autism, no matter what RFK says this week. This is not an unsettled question. Evidence summarized here: sciencebasedmedicine.org/tylenol-and-...
Tylenol and Autism
Earlier this year, HHS secretary RFK Jr. predicted that, "By September, we will know what has caused the autism epidemic and we'll be able to eliminate those exposures." Scientists have been researc
sciencebasedmedicine.org
September 21, 2025 at 10:40 PM
Acetaminophen/paracetamol use in pregnancy doesn't cause autism, no matter what RFK says this week. This is not an unsettled question. Evidence summarized here: sciencebasedmedicine.org/tylenol-and-...
Reposted by Charlotte Capitanchik
Only single cell sequencing of the all these post docs will reveal why
September 19, 2025 at 8:54 AM
Only single cell sequencing of the all these post docs will reveal why
Congratulations to @bencekover.bsky.social for winning the best talk prize for schooling us all on best practises in mass scRNA-Seq data integration #Londonomics2025
September 2, 2025 at 10:07 PM
Congratulations to @bencekover.bsky.social for winning the best talk prize for schooling us all on best practises in mass scRNA-Seq data integration #Londonomics2025
Can’t thank our career mentors enough for the great discussions in our mentorship session @margaridamcm.bsky.social @kristinaulicna.bsky.social @gavinpaulkelly.bsky.social and Mara Tatari 💪#Londonomics2025
September 2, 2025 at 10:05 PM
Can’t thank our career mentors enough for the great discussions in our mentorship session @margaridamcm.bsky.social @kristinaulicna.bsky.social @gavinpaulkelly.bsky.social and Mara Tatari 💪#Londonomics2025
In the afternoon we had an excellent talk about AlphaMissense and AlphaGenome from @avsecz.bsky.social who generously allowed us to heckle him during the talk, answering all our questions!
September 2, 2025 at 7:02 PM
In the afternoon we had an excellent talk about AlphaMissense and AlphaGenome from @avsecz.bsky.social who generously allowed us to heckle him during the talk, answering all our questions!
In the morning we enjoyed 11 short talks from computational biology ECRs - I especially liked @saniyakhullar.bsky.social’s talk on incorporating prior PPI knowledge into gene regulatory network inference #londonomics2025
September 2, 2025 at 6:59 PM
In the morning we enjoyed 11 short talks from computational biology ECRs - I especially liked @saniyakhullar.bsky.social’s talk on incorporating prior PPI knowledge into gene regulatory network inference #londonomics2025
Had such a great time at #Londonomics2025 today - excellent talks and discussions - thank you to everyone who came along and shared their ideas with us.
September 2, 2025 at 6:55 PM
Had such a great time at #Londonomics2025 today - excellent talks and discussions - thank you to everyone who came along and shared their ideas with us.
Sounds like a wonderful position
🚨🚨🚨
Please RT!
We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets.
Deadline: 30/09/25👇
Please RT!
We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets.
Deadline: 30/09/25👇
www.upf.edu
September 1, 2025 at 11:09 AM
Sounds like a wonderful position
RUN, DON'T WALK to sign up for the londonomics symposium! we gotta order the sandwiches soon, so grab your ticket while you can! come hear about AlphaGenome & other great omics work, get career advice and hang out with us, it'll be so great i promise register.oxfordabstracts.com/event/75604?...
Oxford Abstracts Delegate Registration
register.oxfordabstracts.com
August 18, 2025 at 4:43 PM
RUN, DON'T WALK to sign up for the londonomics symposium! we gotta order the sandwiches soon, so grab your ticket while you can! come hear about AlphaGenome & other great omics work, get career advice and hang out with us, it'll be so great i promise register.oxfordabstracts.com/event/75604?...
Reposted by Charlotte Capitanchik
Not sure how many scientists here have tried Claude Code or similar command line coding assistants. I had a complicated family property tax problem that was best solved by a brute force Monte Carlo simulation approach, so I spent a few days coding up and analyzing a model with Claude Code.
August 12, 2025 at 12:47 PM
Not sure how many scientists here have tried Claude Code or similar command line coding assistants. I had a complicated family property tax problem that was best solved by a brute force Monte Carlo simulation approach, so I spent a few days coding up and analyzing a model with Claude Code.
Did GPT-5 make this graph?
August 7, 2025 at 5:08 PM
Did GPT-5 make this graph?
Excited for this! Please do come and present your work :D
Are you an Early Career Researcher in bioinformatics? Then this symposium is for you 💡
Join us for a day of talks, networking and career discussions. Present your work to get fresh new ideas and the chance to win prizes 💸
Featuring @avsecz.bsky.social of Google DeepMind as our keynote speaker⚡️
Join us for a day of talks, networking and career discussions. Present your work to get fresh new ideas and the chance to win prizes 💸
Featuring @avsecz.bsky.social of Google DeepMind as our keynote speaker⚡️
July 29, 2025 at 11:27 AM
Excited for this! Please do come and present your work :D
Reposted by Charlotte Capitanchik
This work is the result of a fantastic collaboration between my lab at the University of Michigan, Mitchell Guttman lab at Caltech, and Marko Jovanovic lab at Columbia University.
www.cell.com/cell/fulltex...
#Ribosomes #Science #CryoEM #RNA
www.cell.com/cell/fulltex...
#Ribosomes #Science #CryoEM #RNA
SPIDR enables multiplexed mapping of RNA-protein interactions and uncovers a mechanism for selective translational suppression upon cell stress
SPIDR, a massively multiplexed method that simultaneously maps dozens of RNA-binding
proteins to their RNA targets at single-nucleotide resolution, uncovers new RNA-protein
interactions and provides c...
www.cell.com
July 22, 2025 at 5:12 PM
This work is the result of a fantastic collaboration between my lab at the University of Michigan, Mitchell Guttman lab at Caltech, and Marko Jovanovic lab at Columbia University.
www.cell.com/cell/fulltex...
#Ribosomes #Science #CryoEM #RNA
www.cell.com/cell/fulltex...
#Ribosomes #Science #CryoEM #RNA
😂
this is the very technology orgs like the UN is adopting to "solve" gender inequity
Study finds A.I. LLMs advise women to ask for lower salaries than men. When prompted w/ a user profile of same education, experience & job role, differing only by gender, ChatGPT advised the female applicant to request $280K salary; Male applicant=$400K.
thenextweb.com/news/chatgpt...
thenextweb.com/news/chatgpt...
July 21, 2025 at 11:16 AM
😂
Reposted by Charlotte Capitanchik
New ENCODE4 long-read RNA-seq transcripts track for hg38 and mm10. Triplets (e.g. [1,1,3]) indicate start site, exon combination, and stop site for each transcript. Enrichment scores show how these change across tissue and cell line samples.
Read more: genome.ucsc.edu/gold...
Read more: genome.ucsc.edu/gold...
July 16, 2025 at 6:27 PM
New ENCODE4 long-read RNA-seq transcripts track for hg38 and mm10. Triplets (e.g. [1,1,3]) indicate start site, exon combination, and stop site for each transcript. Enrichment scores show how these change across tissue and cell line samples.
Read more: genome.ucsc.edu/gold...
Read more: genome.ucsc.edu/gold...
Reposted by Charlotte Capitanchik
"It is not just that LLM’s fail to induce proper world models of chess. It’s that they never induce proper worlds of anything. Everything that they do is through mimicry, rather than abstracted cognition across proper world models."
garymarcus.substack.com/p/generative...
garymarcus.substack.com/p/generative...
Generative AI’s crippling and widespread failure to induce robust models of the world
LLM failures to reason, as documented in Apple’s Illusion of Thinking paper, are really only part of a much deeper problem
garymarcus.substack.com
June 30, 2025 at 8:26 AM
"It is not just that LLM’s fail to induce proper world models of chess. It’s that they never induce proper worlds of anything. Everything that they do is through mimicry, rather than abstracted cognition across proper world models."
garymarcus.substack.com/p/generative...
garymarcus.substack.com/p/generative...
Totally agree!! "How to make the next PDB" This is exactly what we've attempted to do for functional genomics with flow.bio www.biorxiv.org/content/10.1...
Michael Bronstein @mmbronstein.bsky.social at #AIxBio
June 23, 2025 at 4:36 PM
Totally agree!! "How to make the next PDB" This is exactly what we've attempted to do for functional genomics with flow.bio www.biorxiv.org/content/10.1...
incredible work by an incredible scientist (and friend)! very beautiful figures too www.cell.com/cell-systems...
The molecular landscape of cellular metal ion biology
Aulakh et al. systematically investigated how metal ion availability impacts yeast
biochemistry. Their metallomic, proteomic, and genetic screens reveal the widespread
metal concentration dependence o...
www.cell.com
June 13, 2025 at 7:21 PM
incredible work by an incredible scientist (and friend)! very beautiful figures too www.cell.com/cell-systems...
Reposted by Charlotte Capitanchik
"Women are PIs on 58% of the canceled grants, although they are PIs on only 34% of all active NSF grants.
Similarly, Blacks are PIs on 17% of the terminated grants, although they make only 4% of the total pool. Hispanic PIs and those with disabilities were twice as likely to lose a grant."
Similarly, Blacks are PIs on 17% of the terminated grants, although they make only 4% of the total pool. Hispanic PIs and those with disabilities were twice as likely to lose a grant."
Another scoop from Jeff Mervis (@policyhound.bsky.social): NSF's ~1400 grant terminations have disproportionately affected PIs from groups underrepresented in science: women, racial & ethnic minorities, & those with disabilities. 1/3
www.science.org/content/arti...
www.science.org/content/arti...
Trump officials take steps toward a radically different NSF
Efforts to shrink staff, budget, and focus have alarmed members of Congress
www.science.org
May 13, 2025 at 10:09 PM
"Women are PIs on 58% of the canceled grants, although they are PIs on only 34% of all active NSF grants.
Similarly, Blacks are PIs on 17% of the terminated grants, although they make only 4% of the total pool. Hispanic PIs and those with disabilities were twice as likely to lose a grant."
Similarly, Blacks are PIs on 17% of the terminated grants, although they make only 4% of the total pool. Hispanic PIs and those with disabilities were twice as likely to lose a grant."