Finally, we provide a suite of tools that allow users users to convert PDB into ProFlex, search for proteins with similar flexibility patterns in structural databases, and compare ProFlex-encoded protein sequences with each other.

We hope that our approach will facilitate new insights into protein function and make a better use of the expanding structural atlas.

Manuscript: doi.org/10.1038/s414...
ProFlex Suite: github.com/DamianJM/pro...

#protein #dynamics #phage

We analysed 15 major capsid protein sequences from Tevenvirinae phages using sequence, structutal and ProFlex comparisons and demonstrated that all tested approaches detect the underlying phylogenetic relationship and provide complementary information about the proteins.

Together with my very good friend and brilliant colleague Damian Magill we developed ProFlex, a protein “alphabet” that turns protein flexibility patterns into an easy-to-compare sequences.

This UKRI AI CDT SUSTAIN project and will be supervised by Dr Didier Devaurs and Dr Leighton Pritchard (Strathclyde), Dr Victoria Smyth (AFBI), and me.
You will learn a lot about #AI, machine learning, bioinformatics, microbiology, food production, animal health, and #phage!

Very interesting - but I can't seem to find the upper size limit of the payload that can be delivered this way in the paper

offers a world-leading research environment and abundant opportunities for personal and professional growth in a supportive and welcoming community. Further information about the scheme can be found on Queen's University website.
www.qub.ac.uk/Research/our...

#MCSA

Finally, our work underscores the importance of integrating genomic data with public health measures to better prepare for future pandemics.

#SARSCoV2 #Ireland #NorthernIreland #COVID19 #SARS

Our study:
🔬 Demonstrates the critical role of whole genome sequencing (WGS) in identifying introduction events
🌍 Explores the influence of population density, deprivation, and policy on transmission
📊 Provides aa scalable framework for tracking infectious diseases globally

Key findings:
🔷 England accounted for 57% of introductions
🔷 Introduction rates for variants were comparable, except Delta, which was higher in NI
🔷 Over 60% of introductions resulted in detection of only a single descendant