Mitchell Stark
@thestarklab.bsky.social
#Melanoma researcher motivated to find clues for early detection.
A/Professor and Principal Research Fellow - Skin Cancer Genomics and Biomarker Discovery Lab
A/Professor and Principal Research Fellow - Skin Cancer Genomics and Biomarker Discovery Lab
✨This may allow better risk stratification, targeted screening or therapeutic targeting and ablation of BRAF V600E-mutant melanomas to prevent tumour initiation.
October 31, 2025 at 1:08 AM
✨This may allow better risk stratification, targeted screening or therapeutic targeting and ablation of BRAF V600E-mutant melanomas to prevent tumour initiation.
✨Uncovering differences in the distribution of BRAF V600E-mutant melanocytes may allow us to identify at-risk skin areas before malignant transformation occurs.
October 31, 2025 at 1:08 AM
✨Uncovering differences in the distribution of BRAF V600E-mutant melanocytes may allow us to identify at-risk skin areas before malignant transformation occurs.
What does this mean??
✨ The widespread presence of BRAF V600E-mutant melanocytes across clinically normal skin, including naevus- and melanoma-adjacent, photodamaged, photoprotected and neonatal skin, shifts our understanding of melanoma initiation.
✨ The widespread presence of BRAF V600E-mutant melanocytes across clinically normal skin, including naevus- and melanoma-adjacent, photodamaged, photoprotected and neonatal skin, shifts our understanding of melanoma initiation.
October 31, 2025 at 1:08 AM
What does this mean??
✨ The widespread presence of BRAF V600E-mutant melanocytes across clinically normal skin, including naevus- and melanoma-adjacent, photodamaged, photoprotected and neonatal skin, shifts our understanding of melanoma initiation.
✨ The widespread presence of BRAF V600E-mutant melanocytes across clinically normal skin, including naevus- and melanoma-adjacent, photodamaged, photoprotected and neonatal skin, shifts our understanding of melanoma initiation.
Precancerous fields are commonly found in the skin of patients at high risk for melanoma and are up to 20-fold denser and 50% more frequent in tumour-adjacent skin.
October 31, 2025 at 1:08 AM
Precancerous fields are commonly found in the skin of patients at high risk for melanoma and are up to 20-fold denser and 50% more frequent in tumour-adjacent skin.
We examined BRAF V600E mutations in 97 histologically and clinically normal, nonlesional skin samples from an Australian cohort at high-risk of melanoma. We identified BRAF V600E-mutant melanocytes in skin surrounding naevi and primary melanomas, even years after tumour excision.
October 31, 2025 at 1:08 AM
We examined BRAF V600E mutations in 97 histologically and clinically normal, nonlesional skin samples from an Australian cohort at high-risk of melanoma. We identified BRAF V600E-mutant melanocytes in skin surrounding naevi and primary melanomas, even years after tumour excision.
Here's a snapshot of what we found:
🌟 The origins of cutaneous melanoma are often traced to visible precursor lesions (e.g. melanocytic naevi), but approximately two-thirds of melanomas arise from clinically healthy skin with no precursor lesion.
🌟 The origins of cutaneous melanoma are often traced to visible precursor lesions (e.g. melanocytic naevi), but approximately two-thirds of melanomas arise from clinically healthy skin with no precursor lesion.
October 31, 2025 at 1:08 AM
Here's a snapshot of what we found:
🌟 The origins of cutaneous melanoma are often traced to visible precursor lesions (e.g. melanocytic naevi), but approximately two-thirds of melanomas arise from clinically healthy skin with no precursor lesion.
🌟 The origins of cutaneous melanoma are often traced to visible precursor lesions (e.g. melanocytic naevi), but approximately two-thirds of melanomas arise from clinically healthy skin with no precursor lesion.