@tdeekens.bsky.social
Reposted
Die Mehrwertsteuer auf Frauenhygieneartikel wurde mit 1.1.2026 gestrichen. Und wie reagieren die Handelskonzerne darauf? Unterschiedlich. Zum Teil sind die Preise sogar gestiegen:
ooe.arbeiterkammer.at/service/pres...
ooe.arbeiterkammer.at/service/pres...
Trotz Steuersenkung: Preise teils gestiegen
AK-Preisbeobachtung zeigt: Entfall der Mehrwertsteuer auf Frauenhygieneartikel wird nicht von allen Händlern weitergegeben.
ooe.arbeiterkammer.at
January 23, 2026 at 9:08 AM
Die Mehrwertsteuer auf Frauenhygieneartikel wurde mit 1.1.2026 gestrichen. Und wie reagieren die Handelskonzerne darauf? Unterschiedlich. Zum Teil sind die Preise sogar gestiegen:
ooe.arbeiterkammer.at/service/pres...
ooe.arbeiterkammer.at/service/pres...
Reposted
💥 I did a drawing that breaks down Transformers in AI
Spent a good amount of time on this one, breaking down concepts in a way that someone new to the subject could come away with basic high-level understanding. I hope it's useful!
Spent a good amount of time on this one, breaking down concepts in a way that someone new to the subject could come away with basic high-level understanding. I hope it's useful!
January 20, 2026 at 2:02 PM
💥 I did a drawing that breaks down Transformers in AI
Spent a good amount of time on this one, breaking down concepts in a way that someone new to the subject could come away with basic high-level understanding. I hope it's useful!
Spent a good amount of time on this one, breaking down concepts in a way that someone new to the subject could come away with basic high-level understanding. I hope it's useful!
Reposted
Our industry loves to create problems in the name of innovation only to turn around and sell you a solution to the problem we just created.
January 21, 2026 at 9:45 PM
Our industry loves to create problems in the name of innovation only to turn around and sell you a solution to the problem we just created.
Reposted
Do you like a free tool? Send money.
Do you use a tool at work? Convince your employer to sponsor it. Stop marketing OSS as free stuff to your employer, and treat it as a cost for the company.
You only endanger the OSS project, if you don't give something in return.
Do you use a tool at work? Convince your employer to sponsor it. Stop marketing OSS as free stuff to your employer, and treat it as a cost for the company.
You only endanger the OSS project, if you don't give something in return.
January 18, 2026 at 9:33 AM
Do you like a free tool? Send money.
Do you use a tool at work? Convince your employer to sponsor it. Stop marketing OSS as free stuff to your employer, and treat it as a cost for the company.
You only endanger the OSS project, if you don't give something in return.
Do you use a tool at work? Convince your employer to sponsor it. Stop marketing OSS as free stuff to your employer, and treat it as a cost for the company.
You only endanger the OSS project, if you don't give something in return.
Reposted
Our new preprint on DUSP4 in cancer is out. In vivo ARTi studies show DUSP4 loss doesn’t cause tumor regression and triggers fast compensatory reactivation. These results challenge DUSP4 as a monotherapy target. Link to preprint: www.biorxiv.org/content/10.6...
DUSP4 knockdown in BRAF V600E mutant colorectal cancer induces cell cycle arrest and halts tumor growth
Oncogenic signaling in cancer cells is essential for proliferation, and its disruption, either through inhibition or overactivation, can provide therapeutic opportunities. Dual specificity phosphatase 4 (DUSP4), a negative regulator of the MAPK pathway that dephosphorylates ERK, has been proposed as a potential target; however, its therapeutic relevance has not been evaluated in vivo. In this study, we show that DUSP4 knock-down induces G1 cell cycle arrest and reduces proliferation in BRAFV600E-mutant and BRAF inhibitor-resistant colorectal cancer models, both in vitro and in vivo, and induces a rapid DUSP5-mediated adaptive response. While treatment achieved tumor stasis indicating disease control, it did not yield tumor regression, suggesting that DUSP4 may have limited efficacy as a monotherapy target in cancer. ### Competing Interest Statement All authors are full time employees at Boehringer Ingelheim RCV.
www.biorxiv.org
January 16, 2026 at 1:08 PM
Our new preprint on DUSP4 in cancer is out. In vivo ARTi studies show DUSP4 loss doesn’t cause tumor regression and triggers fast compensatory reactivation. These results challenge DUSP4 as a monotherapy target. Link to preprint: www.biorxiv.org/content/10.6...
Reposted
I'm joining Cloudflare! Now let's focus on Astro v6 and ship those nice, new features! 🧑🚀🧡☁️
We are joining Cloudflare! astro.build/blog/joining...
The Astro Technology Company joins Cloudflare | Astro
The Astro Technology Company is joining Cloudflare! Astro remains open-source, MIT-licensed, and platform-agnostic. With Cloudflare's support, we're focusing 100% on building the best framework for…
astro.build
January 16, 2026 at 4:03 PM
I'm joining Cloudflare! Now let's focus on Astro v6 and ship those nice, new features! 🧑🚀🧡☁️
Reposted
It's vibe coding only if you don't know what you're doing. A software engineer using AI to speed up development isn't vibe coding. Someone who's never developed anything and doesn't know how AI generated code works is vibe coding.
January 14, 2026 at 3:36 AM
It's vibe coding only if you don't know what you're doing. A software engineer using AI to speed up development isn't vibe coding. Someone who's never developed anything and doesn't know how AI generated code works is vibe coding.
Reposted
Today, we published a security release for @nodejs.org that fixes a critical bug affecting virtually every production Node.js app.
If you use React Server Components, Next.js, or ANY APM tool (Datadog, New Relic, OpenTelemetry), your app could be vulnerable to DoS attacks.
👇
If you use React Server Components, Next.js, or ANY APM tool (Datadog, New Relic, OpenTelemetry), your app could be vulnerable to DoS attacks.
👇
January 13, 2026 at 6:50 PM
Today, we published a security release for @nodejs.org that fixes a critical bug affecting virtually every production Node.js app.
If you use React Server Components, Next.js, or ANY APM tool (Datadog, New Relic, OpenTelemetry), your app could be vulnerable to DoS attacks.
👇
If you use React Server Components, Next.js, or ANY APM tool (Datadog, New Relic, OpenTelemetry), your app could be vulnerable to DoS attacks.
👇
Reposted
back doing my first talk in eight years 🤘
January 9, 2026 at 3:29 PM
back doing my first talk in eight years 🤘
Reposted
The task, not the AI agent, is still the most important bit.
January 5, 2026 at 9:54 PM
The task, not the AI agent, is still the most important bit.
Reposted
When you’re doom posting about how everything is inevitable and no one can stop them, you’re doing their work for them. Stop that
January 3, 2026 at 7:52 PM
When you’re doom posting about how everything is inevitable and no one can stop them, you’re doing their work for them. Stop that
Reposted
❓"When can we expect this feature"
Please refrain from asking this question towards open source maintainers. You generally shouldn't "expect" anything. I don't often agree with DHH but his take on OSS being a gift, not something you're entitled to, is something I relate with.
Please refrain from asking this question towards open source maintainers. You generally shouldn't "expect" anything. I don't often agree with DHH but his take on OSS being a gift, not something you're entitled to, is something I relate with.
December 20, 2025 at 8:42 AM
❓"When can we expect this feature"
Please refrain from asking this question towards open source maintainers. You generally shouldn't "expect" anything. I don't often agree with DHH but his take on OSS being a gift, not something you're entitled to, is something I relate with.
Please refrain from asking this question towards open source maintainers. You generally shouldn't "expect" anything. I don't often agree with DHH but his take on OSS being a gift, not something you're entitled to, is something I relate with.
Reposted
I've integrated Mistral AI models in my little coding agent harness pi and am happy to report that Devstral 2.0 is a good agentic model. Somewhere between Sonnet 4.0 and 4.5. It's also OSS and self-hostable.
Europe is back, baby!
Europe is back, baby!
December 10, 2025 at 9:21 PM
I've integrated Mistral AI models in my little coding agent harness pi and am happy to report that Devstral 2.0 is a good agentic model. Somewhere between Sonnet 4.0 and 4.5. It's also OSS and self-hostable.
Europe is back, baby!
Europe is back, baby!
Reposted
I pointed Amp with the oracle and Opus 4.5 at a vulnerable React and asked it to find the remote control execution issue without googling and it found it very little help. In fact, it found more than one way to exploit it. Really, really cool.
December 4, 2025 at 5:11 PM
I pointed Amp with the oracle and Opus 4.5 at a vulnerable React and asked it to find the remote control execution issue without googling and it found it very little help. In fact, it found more than one way to exploit it. Really, really cool.
Reposted
The year is 2013:
- password managers worked
- you could get most TV content from one or two streaming services
- you could paste links into chats and previews would actually unfurl correctly
- google results contained actual search results
- password managers worked
- you could get most TV content from one or two streaming services
- you could paste links into chats and previews would actually unfurl correctly
- google results contained actual search results
October 31, 2025 at 4:02 PM
The year is 2013:
- password managers worked
- you could get most TV content from one or two streaming services
- you could paste links into chats and previews would actually unfurl correctly
- google results contained actual search results
- password managers worked
- you could get most TV content from one or two streaming services
- you could paste links into chats and previews would actually unfurl correctly
- google results contained actual search results
Reposted
Chatbots — LLMs — do not know facts and are not designed to be able to accurately answer factual questions. They are designed to find and mimic patterns of words, probabilistically. When they’re “right” it’s because correct things are often written down, so those patterns are frequent. That’s all.
June 19, 2025 at 11:21 AM
Chatbots — LLMs — do not know facts and are not designed to be able to accurately answer factual questions. They are designed to find and mimic patterns of words, probabilistically. When they’re “right” it’s because correct things are often written down, so those patterns are frequent. That’s all.
Reposted
Having a blast re-designing all the React Aria examples this week. Flat design is so over – bring back depth! 😃
October 14, 2025 at 5:03 PM
Having a blast re-designing all the React Aria examples this week. Flat design is so over – bring back depth! 😃
Reposted
You want a psychologically safe culture? Don’t let people get away with making it unsafe. A high performing culture? Don’t let people get away with poor quality work. etc.
June 26, 2025 at 3:31 PM
You want a psychologically safe culture? Don’t let people get away with making it unsafe. A high performing culture? Don’t let people get away with poor quality work. etc.
Reposted
Yesterday, @opensourcepledge.com was on Nasdaq Tower in Times Square. I got to be there for it! Thank you to Nasdaq and congratulations to all of the featured companies who #paythemaintainers! 👏 What a great way to keep celebrating #maintainermonth! 💃
May 7, 2025 at 1:10 PM
Yesterday, @opensourcepledge.com was on Nasdaq Tower in Times Square. I got to be there for it! Thank you to Nasdaq and congratulations to all of the featured companies who #paythemaintainers! 👏 What a great way to keep celebrating #maintainermonth! 💃
Reposted
Reposted
Most of what we call "tech" is about getting the right information into a database and trying to prevent the wrong person from reading or updating it.
March 3, 2025 at 10:10 PM
Most of what we call "tech" is about getting the right information into a database and trying to prevent the wrong person from reading or updating it.
Reposted
Here is why I consider AI agents nothing more than software. I'm talking specifically about the pieces of software that do things in a pipeline to complete a task. Let's take booking a flight to Vancouver as an example task.
January 9, 2025 at 7:51 PM
Here is why I consider AI agents nothing more than software. I'm talking specifically about the pieces of software that do things in a pipeline to complete a task. Let's take booking a flight to Vancouver as an example task.
Reposted
