Synthesis Journal
@synthesis1969.bsky.social
An international, peer-reviewed Thieme journal in #chemicalsynthesis, founded in 1969, publishing #reviews and #fullpapers.
🔗 https://www.thieme.de/synthesis/journal-information-55920.htm
🔗 https://www.thieme.de/synthesis/journal-information-55920.htm
#Sulfur is shaping the future of #DrugDiscovery! Wonchul Lee & co-workers review cutting-edge total syntheses of sulfur-rich natural products (2020–2024), from #thioethers to #thiazoles 🧪
👉 buff.ly/CybW19K
👉 buff.ly/CybW19K
November 28, 2025 at 8:00 AM
#Sulfur is shaping the future of #DrugDiscovery! Wonchul Lee & co-workers review cutting-edge total syntheses of sulfur-rich natural products (2020–2024), from #thioethers to #thiazoles 🧪
👉 buff.ly/CybW19K
👉 buff.ly/CybW19K
Yanhua Zhang & co-workers showcase a green, efficient electrochemical method to turn aryl alkynes + CO₂ into acrylic & propionic acids! Using an Al/Pt/Ag–AgBr setup in TBAB/MeCN, yields reach 72% and product selectivity is tunable over time⚡️
#electrochemistry
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#electrochemistry
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November 26, 2025 at 8:00 AM
Yanhua Zhang & co-workers showcase a green, efficient electrochemical method to turn aryl alkynes + CO₂ into acrylic & propionic acids! Using an Al/Pt/Ag–AgBr setup in TBAB/MeCN, yields reach 72% and product selectivity is tunable over time⚡️
#electrochemistry
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#electrochemistry
👉 buff.ly/sNCqP8K
Explore the dynamic world of #spiropyrans & #merocyanines ! Discover how electron-donating and -withdrawing groups shape photochromic behavior using UV/Vis, NMR & DFT insights by Ralf Wolfgang Giernoth & co-workers📊
#photochromism
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#photochromism
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November 24, 2025 at 8:01 AM
Explore the dynamic world of #spiropyrans & #merocyanines ! Discover how electron-donating and -withdrawing groups shape photochromic behavior using UV/Vis, NMR & DFT insights by Ralf Wolfgang Giernoth & co-workers📊
#photochromism
👉 buff.ly/65euLti
#photochromism
👉 buff.ly/65euLti
Transition metal-free #CrossCoupling 🚀 Alkyl fluorides + #Organolithiums react under mild heat with liquid-assisted stirring w/o expensive catalysts🔥 Tolerates 3° fluorides & diverse functional groups🧪 This breakthrough by Wolf & co-workers could reshape TM-free coupling chemistry
👉 buff.ly/tWFwGiw
👉 buff.ly/tWFwGiw
November 21, 2025 at 8:01 AM
Transition metal-free #CrossCoupling 🚀 Alkyl fluorides + #Organolithiums react under mild heat with liquid-assisted stirring w/o expensive catalysts🔥 Tolerates 3° fluorides & diverse functional groups🧪 This breakthrough by Wolf & co-workers could reshape TM-free coupling chemistry
👉 buff.ly/tWFwGiw
👉 buff.ly/tWFwGiw
From Si & Ge to Sn⚗️This review by Guillaume Lefèvre & co-workers explores #bis-alkenyl group XIV compounds – their formation from halide precursors, versatile functionalizations & roles in polymers, materials & fine chemicals🌟
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👉 buff.ly/pqrRST0
November 19, 2025 at 8:00 AM
From Si & Ge to Sn⚗️This review by Guillaume Lefèvre & co-workers explores #bis-alkenyl group XIV compounds – their formation from halide precursors, versatile functionalizations & roles in polymers, materials & fine chemicals🌟
👉 buff.ly/pqrRST0
👉 buff.ly/pqrRST0
Metal-free & radical💥A #xanthate -mediated cascade builds #spiroindolines via addition, spirocyclization & oxidation🌀 Broad scope (esters, nitriles, ketones, lactones) & up to 99% yield ⚗️Unlocking bioactive scaffolds by Luis D. Miranda & co-workers✨
👉 buff.ly/2pAJOcC
👉 buff.ly/2pAJOcC
November 17, 2025 at 8:01 AM
Metal-free & radical💥A #xanthate -mediated cascade builds #spiroindolines via addition, spirocyclization & oxidation🌀 Broad scope (esters, nitriles, ketones, lactones) & up to 99% yield ⚗️Unlocking bioactive scaffolds by Luis D. Miranda & co-workers✨
👉 buff.ly/2pAJOcC
👉 buff.ly/2pAJOcC
Yongseok Kwon & co-workers review a decade of enantioselective C–C bond formation via redox-active esters + #photoredox & CPA catalysis💡 From Minisci α-amino radicals to Friedel–Crafts acylimines, dual activation is opening new stereochemical frontiers⚡
👉 buff.ly/a1JV95z
👉 buff.ly/a1JV95z
November 14, 2025 at 8:01 AM
Yongseok Kwon & co-workers review a decade of enantioselective C–C bond formation via redox-active esters + #photoredox & CPA catalysis💡 From Minisci α-amino radicals to Friedel–Crafts acylimines, dual activation is opening new stereochemical frontiers⚡
👉 buff.ly/a1JV95z
👉 buff.ly/a1JV95z
Turning amides into amines & nitriles with light!💡Using Fe₂(CO)₉ under blue LED irradiation, Christophe Darcel & co-workers showcase a selective, mild #desulfurization via hydrosilylation, a sustainable twist on iron #catalysis
👉 buff.ly/UtXQrvR
👉 buff.ly/UtXQrvR
November 12, 2025 at 8:01 AM
Turning amides into amines & nitriles with light!💡Using Fe₂(CO)₉ under blue LED irradiation, Christophe Darcel & co-workers showcase a selective, mild #desulfurization via hydrosilylation, a sustainable twist on iron #catalysis
👉 buff.ly/UtXQrvR
👉 buff.ly/UtXQrvR
Explore the #gold standard in #catalysis! Dive into our review by Long Li & co-workers on gold-catalyzed asymmetric #alkyne transformations, from ligand engineering to central-to-axial conversions. Discover new paths in #chirality & sustainable synthesis✨
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👉 buff.ly/z0wMqw9
November 10, 2025 at 8:01 AM
Explore the #gold standard in #catalysis! Dive into our review by Long Li & co-workers on gold-catalyzed asymmetric #alkyne transformations, from ligand engineering to central-to-axial conversions. Discover new paths in #chirality & sustainable synthesis✨
👉 buff.ly/z0wMqw9
👉 buff.ly/z0wMqw9
#Organosodium reagents are emerging as greener, more reactive alternatives to lithium🧪 Benzyl sodium shows divergent reactivity with #pyridines, unlocking access to #dihydropyridines 🔍 New mechanistic insights revealed by Eva Hevia & co-workers @evaheviagroup.bsky.social
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👉 buff.ly/DThXVcG
November 7, 2025 at 8:01 AM
#Organosodium reagents are emerging as greener, more reactive alternatives to lithium🧪 Benzyl sodium shows divergent reactivity with #pyridines, unlocking access to #dihydropyridines 🔍 New mechanistic insights revealed by Eva Hevia & co-workers @evaheviagroup.bsky.social
👉 buff.ly/DThXVcG
👉 buff.ly/DThXVcG
🔎 Isocyanoalkenes, an underexplored class of #isocyanides , are unlocking new paths in heterocycle synthesis🌱From biosynthesis to reactivity (conjugate & radical additions), this review by Huan Tian & Fraser Fleming highlights their vast synthetic potential🧪
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👉 buff.ly/tJWJ5Z4
November 5, 2025 at 8:01 AM
🔎 Isocyanoalkenes, an underexplored class of #isocyanides , are unlocking new paths in heterocycle synthesis🌱From biosynthesis to reactivity (conjugate & radical additions), this review by Huan Tian & Fraser Fleming highlights their vast synthetic potential🧪
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👉 buff.ly/tJWJ5Z4
Discover how chiral Pd complexes enable enantioselective #SuzukiMiyaura reactions with chain-walking🚀 A new path to pharmaceutically relevant, enantiomerically enriched targets by James Morken & co-workers✨
#organoboron #catalysis
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#organoboron #catalysis
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November 3, 2025 at 8:01 AM
Discover how chiral Pd complexes enable enantioselective #SuzukiMiyaura reactions with chain-walking🚀 A new path to pharmaceutically relevant, enantiomerically enriched targets by James Morken & co-workers✨
#organoboron #catalysis
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#organoboron #catalysis
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#Morpholine amides take the spotlight🌟 Yohei Ogiwara reviews their unique reactivity & chemoselectivity in ketone, aldehyde & acylsilane synthesis🧪 Applications include natural product synthesis, Vilsmeier–Haack reactions & polymer recycling!
#OpenAccess 👉 buff.ly/34Wm4nT
#OpenAccess 👉 buff.ly/34Wm4nT
October 31, 2025 at 8:01 AM
#Morpholine amides take the spotlight🌟 Yohei Ogiwara reviews their unique reactivity & chemoselectivity in ketone, aldehyde & acylsilane synthesis🧪 Applications include natural product synthesis, Vilsmeier–Haack reactions & polymer recycling!
#OpenAccess 👉 buff.ly/34Wm4nT
#OpenAccess 👉 buff.ly/34Wm4nT
William Erb & co-workers show how #hexafluoroisopropanol (HFIP) promotes pseudo-benzylic substitutions, enabling access to bulky diphosphine ligands & phosphonates🧪 Key tools for metal complexes & #phosphine synthesis🌟
#ferrocene
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#ferrocene
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October 29, 2025 at 8:02 AM
William Erb & co-workers show how #hexafluoroisopropanol (HFIP) promotes pseudo-benzylic substitutions, enabling access to bulky diphosphine ligands & phosphonates🧪 Key tools for metal complexes & #phosphine synthesis🌟
#ferrocene
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#ferrocene
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A fresh look at #gold & #platinum catalysis! ✨ Véronique Michelet @vmichelet06.bsky.social & co-workers review [2+2+2] Prins-type #cyclizations with alkynes/allenes, alkenes & carbonyls🔬 Covers intra/intermolecular strategies & enantioselective applications 🌟
👉 buff.ly/roTiTeW
👉 buff.ly/roTiTeW
October 27, 2025 at 8:02 AM
A fresh look at #gold & #platinum catalysis! ✨ Véronique Michelet @vmichelet06.bsky.social & co-workers review [2+2+2] Prins-type #cyclizations with alkynes/allenes, alkenes & carbonyls🔬 Covers intra/intermolecular strategies & enantioselective applications 🌟
👉 buff.ly/roTiTeW
👉 buff.ly/roTiTeW
Rapid access to 1,2- #diazepines from #pyridines via ylide formation under 370 nm light, as reported in the paper of Tomislav Rovis & coworkers🚀 Tuning the protecting group enables diverse substrates, offering a one-pot route to rare drug-like cores💊
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👉 buff.ly/UXBkq9a
October 24, 2025 at 7:02 AM
Rapid access to 1,2- #diazepines from #pyridines via ylide formation under 370 nm light, as reported in the paper of Tomislav Rovis & coworkers🚀 Tuning the protecting group enables diverse substrates, offering a one-pot route to rare drug-like cores💊
👉 buff.ly/UXBkq9a
👉 buff.ly/UXBkq9a
⚡Charge-enhanced H-bond & #Brønsted acid catalysis is redefining synthetic chemistry! Boosting rates & selectivity, these systems, like #amidinium & cationic phosphoric acids, bring enzyme-like efficiency, as highlighted in our review by Travis Dudding & co-workers🚀
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👉 buff.ly/yidWGLw
October 22, 2025 at 7:01 AM
⚡Charge-enhanced H-bond & #Brønsted acid catalysis is redefining synthetic chemistry! Boosting rates & selectivity, these systems, like #amidinium & cationic phosphoric acids, bring enzyme-like efficiency, as highlighted in our review by Travis Dudding & co-workers🚀
👉 buff.ly/yidWGLw
👉 buff.ly/yidWGLw
Ni-catalyzed selective monodefluorinative alkylcarbonylation of α-CF₃ styrenes with alkylzinc pivalates under 1 atm CO gas by Jie Li & co-workers🚀 Mild conditions and broad substrate scope make this method highly versatile⚡
#monodefluorination #nickel #catalysis
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#monodefluorination #nickel #catalysis
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October 20, 2025 at 7:01 AM
Ni-catalyzed selective monodefluorinative alkylcarbonylation of α-CF₃ styrenes with alkylzinc pivalates under 1 atm CO gas by Jie Li & co-workers🚀 Mild conditions and broad substrate scope make this method highly versatile⚡
#monodefluorination #nickel #catalysis
👉 buff.ly/3EtnXgO
#monodefluorination #nickel #catalysis
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Exploring #enyne metathesis in green solvents, supercritical fluids & under microwave tech🌱 From cross- to ring-closing pathways, #ruthenium catalysts & tandem strategies, discover it all in this review by Mao, Melot @rmelot.bsky.social & Michelet @vmichelet06.bsky.social 🚀
👉 buff.ly/XNGUsN9
👉 buff.ly/XNGUsN9
October 17, 2025 at 7:02 AM
Exploring #enyne metathesis in green solvents, supercritical fluids & under microwave tech🌱 From cross- to ring-closing pathways, #ruthenium catalysts & tandem strategies, discover it all in this review by Mao, Melot @rmelot.bsky.social & Michelet @vmichelet06.bsky.social 🚀
👉 buff.ly/XNGUsN9
👉 buff.ly/XNGUsN9
Harnessing sunlight for C–C bond formation☀️ Dimethyl-aniline–alkyl halide charge transfer complexes enable reactions with #malonates , #malononitriles & 2-cyano-esters 🔬✨ DFT unveils the mechanism in this study by Alex Szpilman @amszpilman.bsky.social & co-workers
#photochemistry
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#photochemistry
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October 15, 2025 at 7:01 AM
Harnessing sunlight for C–C bond formation☀️ Dimethyl-aniline–alkyl halide charge transfer complexes enable reactions with #malonates , #malononitriles & 2-cyano-esters 🔬✨ DFT unveils the mechanism in this study by Alex Szpilman @amszpilman.bsky.social & co-workers
#photochemistry
👉 buff.ly/XNGUsN9
#photochemistry
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Join Thieme #Cheminar “Boron in Organic Synthesis”🔬 with our speakers Profs. Varinder Aggarwal (UK), Andrei Yudin (Canada) & Benjamin Stokes (USA), hosted by Prof. Thierry Ollevier and brought to you by @synopenjournal.bsky.social
📅October 16, 2025 ⏰3 PM (GMT+2)
👉 buff.ly/v41RiQI
📅October 16, 2025 ⏰3 PM (GMT+2)
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October 13, 2025 at 8:02 AM
Join Thieme #Cheminar “Boron in Organic Synthesis”🔬 with our speakers Profs. Varinder Aggarwal (UK), Andrei Yudin (Canada) & Benjamin Stokes (USA), hosted by Prof. Thierry Ollevier and brought to you by @synopenjournal.bsky.social
📅October 16, 2025 ⏰3 PM (GMT+2)
👉 buff.ly/v41RiQI
📅October 16, 2025 ⏰3 PM (GMT+2)
👉 buff.ly/v41RiQI
From Ziegler’s legacy to today’s 🚀 #Organoaluminum chemistry is evolving: hydro-/ #carbometallation, terminal #alumination & C–H activation open new paths! Dive into the review by Piccardi & Micouin @lmicouin.bsky.social ✨
👉 buff.ly/XNGUsN9
👉 buff.ly/XNGUsN9
October 13, 2025 at 7:02 AM
From Ziegler’s legacy to today’s 🚀 #Organoaluminum chemistry is evolving: hydro-/ #carbometallation, terminal #alumination & C–H activation open new paths! Dive into the review by Piccardi & Micouin @lmicouin.bsky.social ✨
👉 buff.ly/XNGUsN9
👉 buff.ly/XNGUsN9
🔬 Check out the 2025 #NobelPrize in Chemistry!
This year’s award goes to Susumu Kitagawa, Richard Robson, and Omar M. Yaghi for their pioneering work on metal–organic frameworks (#MOFs), highly porous materials that can capture CO₂, store gases, and even pull water from the air!
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This year’s award goes to Susumu Kitagawa, Richard Robson, and Omar M. Yaghi for their pioneering work on metal–organic frameworks (#MOFs), highly porous materials that can capture CO₂, store gases, and even pull water from the air!
👉 buff.ly/Tj6ROAv
October 10, 2025 at 7:02 PM
🔬 Check out the 2025 #NobelPrize in Chemistry!
This year’s award goes to Susumu Kitagawa, Richard Robson, and Omar M. Yaghi for their pioneering work on metal–organic frameworks (#MOFs), highly porous materials that can capture CO₂, store gases, and even pull water from the air!
👉 buff.ly/Tj6ROAv
This year’s award goes to Susumu Kitagawa, Richard Robson, and Omar M. Yaghi for their pioneering work on metal–organic frameworks (#MOFs), highly porous materials that can capture CO₂, store gases, and even pull water from the air!
👉 buff.ly/Tj6ROAv
Versatile 1,2-oxazin-4-ones pave the way to enantiopure amino #polyols 🧩 Reissig, Zimmer & co-workers show syn/anti selectivity in #Grignard & #enolate additions, δ-lactone & bicyclic polyol formation, plus Pd & SmI₂ reductions⚡
👉 buff.ly/uZan4s9
👉 buff.ly/uZan4s9
October 10, 2025 at 7:01 AM
Versatile 1,2-oxazin-4-ones pave the way to enantiopure amino #polyols 🧩 Reissig, Zimmer & co-workers show syn/anti selectivity in #Grignard & #enolate additions, δ-lactone & bicyclic polyol formation, plus Pd & SmI₂ reductions⚡
👉 buff.ly/uZan4s9
👉 buff.ly/uZan4s9
🚀 Explore cutting-edge strategies for turning propargyl alcohols into #allenes ✨ A short review by Amgoune & co-workers (ICBMS) highlights how transition-metal #photoredox catalysisdrive these advances through oxidative addition & photoinduced C–O cleavage⚡
👉 buff.ly/Sftvtf9
👉 buff.ly/Sftvtf9
October 8, 2025 at 7:02 AM
🚀 Explore cutting-edge strategies for turning propargyl alcohols into #allenes ✨ A short review by Amgoune & co-workers (ICBMS) highlights how transition-metal #photoredox catalysisdrive these advances through oxidative addition & photoinduced C–O cleavage⚡
👉 buff.ly/Sftvtf9
👉 buff.ly/Sftvtf9