Syed A Ahmad, MD
syedaahmad5.bsky.social
Syed A Ahmad, MD
@syedaahmad5.bsky.social
Director University of Cincinnati Cancer Center. Chief Division of Surgical Oncology. Cincinnati Ohio.
Adjuvant Chemotherapy After Resection of Localized Pancreatic Adenocarcinoma Following Preoperative FOLFIRINOX ⁦‪@JAMAOnc‬⁩ ⁦‪@MarcBesselink‬⁩

jamanetwork.com/journals/jam...
Adjuvant Chemotherapy After Resection of Pancreatic Adenocarcinoma Following Preoperative FOLFIRINOX
This cohort study investigates the association of adjuvant chemotherapy following resection of pancreatic adenocarcinoma after preoperative FOLFIRINOX in full or modified dosing with overall survival,...
jamanetwork.com
April 16, 2025 at 11:43 AM
The role of 18F-fluorodeoxyglucose positron emission tomography/computed tomography–derived parameters as prognostic factors in patients undergoing resection for pancreatic ductal adenocarcinoma ⁦‪@SurgJournal‬⁩

www.surgjournal.com/article/S003...
The role of 18F-fluorodeoxyglucose positron emission tomography/computed tomography–derived parameters as prognostic factors in patients undergoing resection for pancreatic ductal adenocarcinoma
The aim of this study is to investigate the role of maximum standardized uptake and tumor-to-liver ratio derived from preoperative 18F-fluorodeoxyglucose positron emission tomography/computed tomograp...
www.surgjournal.com
April 16, 2025 at 11:38 AM
Prognostic significance of the cachexia index for patients with perihilar cholangiocarcinoma ⁦‪@SurgJournal‬⁩

www.surgjournal.com/article/S003...
Prognostic significance of the cachexia index for patients with perihilar cholangiocarcinoma
The prognostic value of the preoperative cachexia index for patients with perihilar cholangiocarcinoma remains unclear.
www.surgjournal.com
April 16, 2025 at 11:34 AM
Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy (CRS-HIPEC) of Extraperitoneal Abdominal Disease, is it Appropriate? ⁦‪@AnnSurgOncol‬⁩

link.springer.com/article/10.1...
Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy (CRS-HIPEC) of Extraperitoneal Abdominal Disease, is it Appropriate? - Annals of Surgical Oncology
Introduction Cytoreductive surgery-hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) candidates often have extraperitoneal abdominal disease. Current expert peritoneal surface malignancy (PSM) gui...
link.springer.com
April 16, 2025 at 11:32 AM
Diagnostic Certainty in Characterizing Liver Lesions in Rectal Cancer: Abbreviated Liver MRI versus CT ⁦‪@AnnSurgOncol‬⁩

link.springer.com/article/10.1...
Diagnostic Certainty in Characterizing Liver Lesions in Rectal Cancer: Abbreviated Liver MRI versus CT - Annals of Surgical Oncology
Background Early diagnosis of metastases is crucial but routine staging with contrast-enhanced multidetector computed tomography (ceMDCT) is suboptimal. A total of 20% will have indeterminate or too s...
link.springer.com
April 16, 2025 at 11:31 AM
Significance of Tumor Microvasculature in the Tumor Microenvironment in Adenocarcinoma with EGFR Common Mutations ⁦‪@AnnSurgOncol‬⁩

link.springer.com/article/10.1...
Significance of Tumor Microvasculature in the Tumor Microenvironment in Adenocarcinoma with EGFR Common Mutations - Annals of Surgical Oncology
Background Tumor microvasculature is an important component of the tumor microenvironment (TME), and it has been reported that tumor microvasculature induces TME to become immunosuppressive via vascul...
link.springer.com
April 16, 2025 at 11:30 AM
Assessing Endoscopic Response in Locally Advanced Rectal Cancer Treated with Total Neoadjuvant Therapy: Development and Validation of a Highly Accurate Convolutional Neural Network ⁦‪@AnnSurgOncol‬⁩

link.springer.com/article/10.1...
Assessing Endoscopic Response in Locally Advanced Rectal Cancer Treated with Total Neoadjuvant Therapy: Development and Validation of a Highly Accurate Convolutional Neural Network - Annals of Surgica...
Background Rectal tumors display varying degrees of response to total neoadjuvant therapy (TNT). We evaluated the performance of a convolutional neural network (CNN) in interpreting endoscopic images ...
link.springer.com
April 16, 2025 at 11:29 AM
Technical Guidelines for Safe Mesojejunum Dissection During Pancreaticoduodenectomy: Unveiling Critical Techniques in a Complex Procedure ⁦‪@AnnSurgOncol‬⁩

link.springer.com/article/10.1...
Technical Guidelines for Safe Mesojejunum Dissection During Pancreaticoduodenectomy: Unveiling Critical Techniques in a Complex Procedure - Annals of Surgical Oncology
Background Pancreaticoduodenectomy (PD) is a complex procedure involving the dissection of the superior mesenteric artery and vein. However, a safe and standardized technique for dissecting the jejuna...
link.springer.com
March 21, 2025 at 3:04 PM
Abuse potential and analgesic efficacy of intravenous hydromorphone bolus administration among hospitalized patients with cancer pain: A double‐blind, double dummy, randomized crossover trial ⁦‪@JournalCancer‬⁩

acsjournals.onlinelibrary.wiley.com/doi/10.1002/...
Abuse potential and analgesic efficacy of intravenous hydromorphone bolus administration among hospitalized patients with cancer pain: A double‐blind, double dummy, randomized crossover trial
Slow intravenous (iv) hydromorphone infusion resulted in similar abuse liability potential and pain improvement but less sedation than fast injection. These findings, taken together, suggest that the...
acsjournals.onlinelibrary.wiley.com
March 19, 2025 at 11:26 AM
Inter-rater variability for the American Society of Anesthesiologists classification in patients undergoing hepato-pancreato-biliary surgery (MILESTONE-2): international survey among surgeons and anaesthesiologists ⁦‪@BJSurgery‬⁩

academic.oup.com/bjsopen/arti...
Inter-rater variability for the American Society of Anesthesiologists classification in patients undergoing hepato-pancreato-biliary surgery (MILESTONE-2): international survey among surgeons and anae...
This is an international survey and case-vignette study including 1283 participants from 55 countries. Interrater variability regarding the ASA classificat
academic.oup.com
March 19, 2025 at 11:11 AM
Impact of pre-compression versus non-compression before parenchyma transection in left-sided pancreatic resection on the rate of clinically relevant pancreatic fistula: multicentre randomized clinical trial ⁦‪@BJSurgery‬⁩

academic.oup.com/bjs/article-...
Impact of pre-compression versus non-compression before parenchyma transection in left-sided pancreatic resection on the rate of clinically relevant pancreatic fistula: multicentre randomized clinical...
This RCT investigated whether parenchymal pre-compression was effective in reducing pancreatic fistula in distal pancreatectomy. The proportion of patients
academic.oup.com
March 19, 2025 at 11:07 AM
Intra- and Interpatient Drug Response Heterogeneity Exist in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Nongynecologic Cancers ⁦‪@AnnSurgOncol‬⁩

link.springer.com/article/10.1...
Intra- and Interpatient Drug Response Heterogeneity Exist in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Nongynecologic Cancers - Annals of Surgical Onc...
Background Select patients with peritoneal metastases are treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC). We assayed for intra- and interpatient drug resp...
link.springer.com
March 19, 2025 at 11:06 AM
Preoperative Frailty and Malnutrition in Surgical Oncology Patients Predicts Higher Postoperative Adverse Events and Worse Survival: Results of a Blinded, Prospective Trial ⁦‪@AnnSurgOncol‬⁩

link.springer.com/article/10.1...
Preoperative Frailty and Malnutrition in Surgical Oncology Patients Predicts Higher Postoperative Adverse Events and Worse Survival: Results of a Blinded, Prospective Trial - Annals of Surgical Oncolo...
Background Frailty, a multidimensional state leading to reduced physiologic reserve, is associated with worse postoperative outcomes. Despite the availability of various frailty tools, surgeons often ...
link.springer.com
March 19, 2025 at 11:04 AM
Time to Surgery Does Not Affect the Survival Outcome in Patients with Perihilar Cholangiocarcinoma ⁦‪@AnnSurgOncol‬⁩

link.springer.com/article/10.1...
Time to Surgery Does Not Affect the Survival Outcome in Patients with Perihilar Cholangiocarcinoma - Annals of Surgical Oncology
Background The impact of time to surgery (TTS) on survival in patients with perihilar cholangiocarcinoma (PHC) is uncertain. Methods Data from PHC patients scheduled for surgery between 2011 and 2020 ...
link.springer.com
March 19, 2025 at 11:03 AM
Ancestral Differences in Anticancer Treatment Efficacy and Their Underlying Genomic and Molecular Alterations ⁦‪@CD_AACR‬⁩

aacrjournals.org/cancerdiscov...
Ancestral Differences in Anticancer Treatment Efficacy and Their Underlying Genomic and Molecular Alterations
A systematic analysis of clinical trial data uncovers ancestral differences in clinical outcomes, providing insights to advance more precise treatments that are tailored to diverse populations.
aacrjournals.org
March 18, 2025 at 10:58 PM
Bismuth Corlette Classification of Hilar Cholangiocarcinoma.
March 2, 2025 at 3:45 PM
Ongoing replication stress tolerance and clonal T cell responses distinguish liver and lung recurrence and outcomes in pancreatic cancer ⁦‪@NatureCancer‬⁩

www.nature.com/articles/s43...
Ongoing replication stress tolerance and clonal T cell responses distinguish liver and lung recurrence and outcomes in pancreatic cancer - Nature Cancer
Sears and colleagues found that ongoing replication stress pathways and T cell clonal responses differentiate liver and lung recurrence and are associated with different clinical outcomes in the conte...
www.nature.com
March 2, 2025 at 12:43 PM
Nationwide Outcome after Pancreatoduodenectomy in Patients at Very High Risk (ISGPS-D) for Postoperative Pancreatic Fistula

journals.lww.com/annalsofsurg...
Nationwide Outcome after Pancreatoduodenectomy in Patients... : Annals of Surgery
is perceived so high that a recent randomized trial advocated prophylactic total pancreatectomy (TP) as alternative aiming to lower this risk. However, current outcomes of ISGPS-D PD remain unknown as...
journals.lww.com
March 2, 2025 at 12:30 PM
Metagenomic next-generation sequencing for the detection of bacterial translocation in the blood of patients following liver, biliary tract or pancreatic surgery ⁦‪@BJS

academic.oup.com/bjs/article/...
Metagenomic next-generation sequencing for the detection of bacterial translocation in the blood of patients following liver, biliary tract or pancreatic surgery
Dear Editor,
academic.oup.com
March 2, 2025 at 12:27 PM
Carbohydrate antigen 19-9 (CA19-9) response after induction FOLFIRINOX for locally advanced pancreatic cancer identifies patients who may benefit from surgical exploration: multicentre, observational cohort study @bjs

academic.oup.com/bjs/article/...
Carbohydrate antigen 19-9 (CA19-9) response after induction FOLFIRINOX for locally advanced pancreatic cancer identifies patients who may benefit from surgical exploration: multicentre, observational ...
In this international retrospective cohort study from the Trans-Atlantic Pancreatic Surgery Consortium, the independent prognostic factors for overall surv
academic.oup.com
March 2, 2025 at 12:25 PM
Improving Recurrence Prediction in Intrahepatic Cholangiocarcinoma: The Synergistic Impact of the FIB-4 Index and Tumor Burden Score on Post-hepatectomy Outcomes ⁦‪@AnnSurgOncol‬⁩

link.springer.com/article/10.1...
Improving Recurrence Prediction in Intrahepatic Cholangiocarcinoma: The Synergistic Impact of the FIB-4 Index and Tumor Burden Score on Post-hepatectomy Outcomes - Annals of Surgical Oncology
Background The prognostic role of the fibrosis-4 (FIB-4) index relative to intrahepatic cholangiocarcinoma (ICC) after hepatectomy remains unclear. This study sought to characterize the impact of the ...
link.springer.com
March 2, 2025 at 12:20 PM
Hierarchically Positioning Laparoscopic Microwave Ablation in the Therapeutic Span of Early Hepatocellular Carcinoma: A Real-Life Comparative Analysis ⁦‪@AnnSurgOncol‬⁩

link.springer.com/article/10.1...
Hierarchically Positioning Laparoscopic Microwave Ablation in the Therapeutic Span of Early Hepatocellular Carcinoma: A Real-Life Comparative Analysis - Annals of Surgical Oncology
Background Laparoscopic microwave ablation (LMWA) has yet to gain a specific place in treatment guidelines for early hepatocellular carcinoma (HCC). This study compared the outcomes of LMWA and trans-...
link.springer.com
March 2, 2025 at 12:19 PM
Targeting Patient-Derived Orthotopic Gastric Cancers with a Fluorescent Humanized Anti-CEA Antibody ⁦‪@AnnSurgOncol‬⁩

link.springer.com/article/10.1...
Targeting Patient-Derived Orthotopic Gastric Cancers with a Fluorescent Humanized Anti-CEA Antibody - Annals of Surgical Oncology
Background Gastric cancer poses a major diagnostic and therapeutic challenge as surgical resection provides the only opportunity for a cure. Specific labeling of gastric cancer could distinguish resec...
link.springer.com
March 2, 2025 at 12:18 PM