Sujay Naik
@sujaynaik.bsky.social
PhD w/ Ella Preger-Ben Noon at Technion | Developmental genetics 🪰🧬
Reposted by Sujay Naik
🧬✨ New 2-part review on the evolution of regulatory DNA (enhancers & promoters)! What started as conversations between Gasper Tkačik @istaresearch.bsky.social and our group @embl.org grew into a broader synthesis.
Preprints here:
Part 1: arxiv.org/abs/2601.19681
Part 2: arxiv.org/abs/2601.21480
Preprints here:
Part 1: arxiv.org/abs/2601.19681
Part 2: arxiv.org/abs/2601.21480
Long-term evolution of regulatory DNA sequences. Part 1: Simulations on global, biophysically-realistic genotype-phenotype maps
Promoters and enhancers are cis-regulatory elements (CREs), DNA sequences that bind transcription factor (TF) proteins to up- or down-regulate target genes. Decades-long efforts yielded TF-DNA interac...
arxiv.org
January 30, 2026 at 10:00 AM
🧬✨ New 2-part review on the evolution of regulatory DNA (enhancers & promoters)! What started as conversations between Gasper Tkačik @istaresearch.bsky.social and our group @embl.org grew into a broader synthesis.
Preprints here:
Part 1: arxiv.org/abs/2601.19681
Part 2: arxiv.org/abs/2601.21480
Preprints here:
Part 1: arxiv.org/abs/2601.19681
Part 2: arxiv.org/abs/2601.21480
Reposted by Sujay Naik
Check out our new preprint on the evolution of enhancer loss. Turns out there are 50 ways to lose a function. We found four of them.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Distinct mechanisms decommission redundant enhancers to facilitate phenotypic evolution
The evolutionary loss of morphological traits is often driven by changes in gene regulation. Many developmental genes are controlled by multiple, redundant enhancers, raising the question of how robus...
www.biorxiv.org
October 28, 2025 at 8:06 PM
Check out our new preprint on the evolution of enhancer loss. Turns out there are 50 ways to lose a function. We found four of them.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...