Steve Reilly
@stevereilly.bsky.social
Assistant Professor of Genetics @ Yale.
Studying how variation in cis-regulatory-elements impacts evolution, complex traits, and more!
http://reilly-lab.com
Studying how variation in cis-regulatory-elements impacts evolution, complex traits, and more!
http://reilly-lab.com
Reposted by Steve Reilly
#ASHG2025 is underway and it's broken the record for the world's largest #genetics conference!
As a member of the program committee (@sgrayg.bsky.social), we'd like to thank everyone at @geneticssociety.bsky.social for making this possible. We can't wait to see what the next few days hold... 🧬🤝
As a member of the program committee (@sgrayg.bsky.social), we'd like to thank everyone at @geneticssociety.bsky.social for making this possible. We can't wait to see what the next few days hold... 🧬🤝
October 14, 2025 at 7:09 PM
#ASHG2025 is underway and it's broken the record for the world's largest #genetics conference!
As a member of the program committee (@sgrayg.bsky.social), we'd like to thank everyone at @geneticssociety.bsky.social for making this possible. We can't wait to see what the next few days hold... 🧬🤝
As a member of the program committee (@sgrayg.bsky.social), we'd like to thank everyone at @geneticssociety.bsky.social for making this possible. We can't wait to see what the next few days hold... 🧬🤝
Reposted by Steve Reilly
Yale has established a new PhD program in Human Genome Sciences and will be accepting applications this fall. We are also searching for an Associate Director of Student Services (a PhD-level position).
Learn more here:
medicine.yale.edu/bbs/tracks/h...
careers.yale.edu/us/en/job/YU...
Learn more here:
medicine.yale.edu/bbs/tracks/h...
careers.yale.edu/us/en/job/YU...
Human Genome Sciences
The overall goal of the Human Genome Sciences (HGS) track is to train the next generation of scientists in the areas of human genomics, genetics, and
medicine.yale.edu
August 13, 2025 at 3:18 PM
Yale has established a new PhD program in Human Genome Sciences and will be accepting applications this fall. We are also searching for an Associate Director of Student Services (a PhD-level position).
Learn more here:
medicine.yale.edu/bbs/tracks/h...
careers.yale.edu/us/en/job/YU...
Learn more here:
medicine.yale.edu/bbs/tracks/h...
careers.yale.edu/us/en/job/YU...
After spending tons of time rebutting our trainee's grant termination.. this response doesn't suggest a 'careful assessment'
There aren't mechanisms that support mid-PhD trainees, so theres nothing to apply to, even though it scored in the top % of all apps.
Not to mention the demotivation.
Ugh.
There aren't mechanisms that support mid-PhD trainees, so theres nothing to apply to, even though it scored in the top % of all apps.
Not to mention the demotivation.
Ugh.
June 10, 2025 at 4:01 PM
After spending tons of time rebutting our trainee's grant termination.. this response doesn't suggest a 'careful assessment'
There aren't mechanisms that support mid-PhD trainees, so theres nothing to apply to, even though it scored in the top % of all apps.
Not to mention the demotivation.
Ugh.
There aren't mechanisms that support mid-PhD trainees, so theres nothing to apply to, even though it scored in the top % of all apps.
Not to mention the demotivation.
Ugh.
Reposted by Steve Reilly
🧠 MPRA + AI to decipher rules of enhancer grammar.
I wrote some thoughts about the fantastic and inspiring work by Robert Frömel & colleagues from @larsplus.bsky.social lab at @crg.eu @upf.edu 👏👏👏
sciencemediacentre.es/en/design-dn...
I wrote some thoughts about the fantastic and inspiring work by Robert Frömel & colleagues from @larsplus.bsky.social lab at @crg.eu @upf.edu 👏👏👏
sciencemediacentre.es/en/design-dn...
Design DNA fragments that control genes in mammalian cells with AI
A team from the Centre for Genomic Regulation (CRG) and Pompeu Fabra University (UPF) in Barcelona has developed an artificial intelligence tool capable of designing regulatory sequences for genes that do not exist in nature. When introduced into cells, these enhancers can increase or decrease gene activity in a specific way depending on the type of cell targeted. According to the authors, ‘the potential applications are enormous. It's like writing software, but for biology.’ The results are published in the journal Cell.
sciencemediacentre.es
May 9, 2025 at 8:11 AM
🧠 MPRA + AI to decipher rules of enhancer grammar.
I wrote some thoughts about the fantastic and inspiring work by Robert Frömel & colleagues from @larsplus.bsky.social lab at @crg.eu @upf.edu 👏👏👏
sciencemediacentre.es/en/design-dn...
I wrote some thoughts about the fantastic and inspiring work by Robert Frömel & colleagues from @larsplus.bsky.social lab at @crg.eu @upf.edu 👏👏👏
sciencemediacentre.es/en/design-dn...
Reposted by Steve Reilly
As a follow-up to the Kaiser interview, here is my exchange with Dr. Bhattacharya starting Sunday evening...
1/n
1/n
May 6, 2025 at 12:33 PM
As a follow-up to the Kaiser interview, here is my exchange with Dr. Bhattacharya starting Sunday evening...
1/n
1/n
Reposted by Steve Reilly
Proud to share our lab’s first student preprint!🚀@j-c-butts.bsky.social, @alwaysrong.bsky.social, @sagergosai.bsky.social leveraged our MPRA models to predict variant effects, providing scores for the complete catalog of human variation. Grateful for another fun collab with @stevereilly.bsky.social.
Excited to share our MPAC preprint, a scalable ensemble of ML models for genome-wide non-coding variant effect prediction and our findings from 575M predictions across databases including @ukbiobank.bsky.social, GTEx, ClinVar, COSMIC, and @gnomad-project.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
| bioRxiv
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
https://www.biorxiv.org/content/10.1101/2025.04.16.648420v1\
April 29, 2025 at 9:11 PM
Proud to share our lab’s first student preprint!🚀@j-c-butts.bsky.social, @alwaysrong.bsky.social, @sagergosai.bsky.social leveraged our MPRA models to predict variant effects, providing scores for the complete catalog of human variation. Grateful for another fun collab with @stevereilly.bsky.social.
Incredibly frustrated today that we had a PhD trainee's NIH grant TERMINATED. He EARNED it by scoring in the top %.
Would love to hear from #murkowski @sendansullivan.bsky.social
@nickbegich.bsky.social think about a bright AK native son's prospects getting cut short due to DOGE lunacy.
Would love to hear from #murkowski @sendansullivan.bsky.social
@nickbegich.bsky.social think about a bright AK native son's prospects getting cut short due to DOGE lunacy.
a man holding a cup of coffee with the words it 's horrible written on his face
ALT: a man holding a cup of coffee with the words it 's horrible written on his face
media.tenor.com
April 25, 2025 at 2:31 PM
Incredibly frustrated today that we had a PhD trainee's NIH grant TERMINATED. He EARNED it by scoring in the top %.
Would love to hear from #murkowski @sendansullivan.bsky.social
@nickbegich.bsky.social think about a bright AK native son's prospects getting cut short due to DOGE lunacy.
Would love to hear from #murkowski @sendansullivan.bsky.social
@nickbegich.bsky.social think about a bright AK native son's prospects getting cut short due to DOGE lunacy.
Reposted by Steve Reilly
Thanks #MITS2025 for inviting me to speak about our deep learning-based search for variants under positive selection in the human genome; more to come! @pardissabeti.bsky.social @stevereilly.bsky.social
Arya Rao in the search for adaptive traits #MITS25
April 24, 2025 at 6:27 PM
Thanks #MITS2025 for inviting me to speak about our deep learning-based search for variants under positive selection in the human genome; more to come! @pardissabeti.bsky.social @stevereilly.bsky.social
Reposted by Steve Reilly
ACTION ITEM-----ACTION ITEM
Implementation of Schedule F
This is what a lot of us have been worried about.
This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs.
BUT THERE IS A COMMENT PERIOD...
1/n
Implementation of Schedule F
This is what a lot of us have been worried about.
This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs.
BUT THERE IS A COMMENT PERIOD...
1/n
the word alert is in a purple circle
ALT: the word alert is in a purple circle
media.tenor.com
April 23, 2025 at 6:03 PM
ACTION ITEM-----ACTION ITEM
Implementation of Schedule F
This is what a lot of us have been worried about.
This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs.
BUT THERE IS A COMMENT PERIOD...
1/n
Implementation of Schedule F
This is what a lot of us have been worried about.
This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs.
BUT THERE IS A COMMENT PERIOD...
1/n
Read through to see our new collaborative work predicting the effects of regulatory variation, for complex traits, rare disease, cancer, and evolution by making ML models of MPRA and scaling to the entire genome.
Excited to share our MPAC preprint, a scalable ensemble of ML models for genome-wide non-coding variant effect prediction and our findings from 575M predictions across databases including @ukbiobank.bsky.social, GTEx, ClinVar, COSMIC, and @gnomad-project.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
| bioRxiv
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
https://www.biorxiv.org/content/10.1101/2025.04.16.648420v1\
April 23, 2025 at 6:01 PM
Read through to see our new collaborative work predicting the effects of regulatory variation, for complex traits, rare disease, cancer, and evolution by making ML models of MPRA and scaling to the entire genome.
Hello Bluesky. The Reilly lab fully made the jump from twitter. Thought it was time to say hello, so: hello!
Excited to join a great community of scientists here!
Excited to join a great community of scientists here!
April 22, 2025 at 4:58 PM
Hello Bluesky. The Reilly lab fully made the jump from twitter. Thought it was time to say hello, so: hello!
Excited to join a great community of scientists here!
Excited to join a great community of scientists here!