Stephen Gordon
@steve-myco.bsky.social
Professor of Infection Biology, University College Dublin 🇮🇪
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Stephen Gordon
@steve-myco.bsky.social
· Sep 24
From Damien Farrell in the lab: 'SNiPgenie: a tool for microbial SNP site detection from whole-genome sequencing data'. doi.org/10.1099/acmi...
Reposted by Stephen Gordon
Really pleased to share the first paper to come out of the lab.
We found that hospital patients were frequently colonised with P. aeruginosa and that the same clone was shared between the gut and the lung.
The phylogenies indicate that the clones moved from lung->gut
www.nature.com/articles/s41...
We found that hospital patients were frequently colonised with P. aeruginosa and that the same clone was shared between the gut and the lung.
The phylogenies indicate that the clones moved from lung->gut
www.nature.com/articles/s41...
High frequency body site translocation of nosocomial Pseudomonas aeruginosa - Nature Communications
Here, the authors report within-host diversity and body site translocation dynamics in hospital samples of Pseudomonas aeruginosa and reveal that body site sharing was likely due to within-patient tra...
www.nature.com
November 25, 2025 at 10:40 AM
Really pleased to share the first paper to come out of the lab.
We found that hospital patients were frequently colonised with P. aeruginosa and that the same clone was shared between the gut and the lung.
The phylogenies indicate that the clones moved from lung->gut
www.nature.com/articles/s41...
We found that hospital patients were frequently colonised with P. aeruginosa and that the same clone was shared between the gut and the lung.
The phylogenies indicate that the clones moved from lung->gut
www.nature.com/articles/s41...
Reposted by Stephen Gordon
What are the associations between #AMR 💊 & #climatechange 🌦️?
In Nature Climate Change, we evaluate existing evidence & define a challenge-oriented research agenda to uncover best equitable practice for synergistic governance responses:
doi.org/10.1038/s415...
@cermes3.bsky.social
In Nature Climate Change, we evaluate existing evidence & define a challenge-oriented research agenda to uncover best equitable practice for synergistic governance responses:
doi.org/10.1038/s415...
@cermes3.bsky.social
A research agenda advancing climate change and antimicrobial resistance as interconnected issues - Nature Climate Change
Interactions between climate change and antimicrobial resistance across terrestrial, aquatic and health systems reveal shared drivers, synergies and trade-offs that shape health and environmental outc...
doi.org
November 24, 2025 at 10:22 AM
What are the associations between #AMR 💊 & #climatechange 🌦️?
In Nature Climate Change, we evaluate existing evidence & define a challenge-oriented research agenda to uncover best equitable practice for synergistic governance responses:
doi.org/10.1038/s415...
@cermes3.bsky.social
In Nature Climate Change, we evaluate existing evidence & define a challenge-oriented research agenda to uncover best equitable practice for synergistic governance responses:
doi.org/10.1038/s415...
@cermes3.bsky.social
Reposted by Stephen Gordon
On the last day of #WAAW 🔔 💊, some historians gave to me …
...a major review of the political-economic factors & concepts shaping #antimicrobial innovation since 1980 - and a call to diversify #antibiotic #R&D moving forward!
www.cambridge.org/core/journal...
For a summary, see the thread (1/9)
...a major review of the political-economic factors & concepts shaping #antimicrobial innovation since 1980 - and a call to diversify #antibiotic #R&D moving forward!
www.cambridge.org/core/journal...
For a summary, see the thread (1/9)
Historicising the “Empty Pipeline”: How Antibiotic Innovation Became a Market Failure (1980–2024) | Public Humanities | Cambridge Core
Historicising the “Empty Pipeline”: How Antibiotic Innovation Became a Market Failure (1980–2024) - Volume 1
www.cambridge.org
November 21, 2025 at 2:37 PM
On the last day of #WAAW 🔔 💊, some historians gave to me …
...a major review of the political-economic factors & concepts shaping #antimicrobial innovation since 1980 - and a call to diversify #antibiotic #R&D moving forward!
www.cambridge.org/core/journal...
For a summary, see the thread (1/9)
...a major review of the political-economic factors & concepts shaping #antimicrobial innovation since 1980 - and a call to diversify #antibiotic #R&D moving forward!
www.cambridge.org/core/journal...
For a summary, see the thread (1/9)
Reposted by Stephen Gordon
Shigellosis is the most common cause of invasive bloody diarrhoea in children younger than 5 years.
The prevention of infection with vaccination & sanitation strategies remains a crucial step in reducing worldwide morbidity & mortality.
Find out more ▶️ tinyurl.com/ard69t83
The prevention of infection with vaccination & sanitation strategies remains a crucial step in reducing worldwide morbidity & mortality.
Find out more ▶️ tinyurl.com/ard69t83
October 6, 2025 at 4:44 PM
Shigellosis is the most common cause of invasive bloody diarrhoea in children younger than 5 years.
The prevention of infection with vaccination & sanitation strategies remains a crucial step in reducing worldwide morbidity & mortality.
Find out more ▶️ tinyurl.com/ard69t83
The prevention of infection with vaccination & sanitation strategies remains a crucial step in reducing worldwide morbidity & mortality.
Find out more ▶️ tinyurl.com/ard69t83
Reposted by Stephen Gordon
Dear #microbiology and #immunology community- I took a break from social media after I deleted my Twitter account, but am back here. Please help me rebuild my community by following me and amplifying this message- I will follow you back. Thank you and I look forward to our many interactions!
October 5, 2025 at 4:10 PM
Dear #microbiology and #immunology community- I took a break from social media after I deleted my Twitter account, but am back here. Please help me rebuild my community by following me and amplifying this message- I will follow you back. Thank you and I look forward to our many interactions!
Reposted by Stephen Gordon
Harvest Time: The UCD Rosemount Orchard has rolled out a carpet of apples 🍎
October 1, 2025 at 4:25 PM
Harvest Time: The UCD Rosemount Orchard has rolled out a carpet of apples 🍎
Reposted by Stephen Gordon
Excited to share Wendy Le Mouëllic’s PhD work, now published in @pnas.org!
It reveals that M. tuberculosis depends on inorganic sulfate import to survive inside host cells—fueling essential processes such as redox balance and stress resistance.
Huge congrats to Wendy & colleagues!
shorturl.at/WbFQC
It reveals that M. tuberculosis depends on inorganic sulfate import to survive inside host cells—fueling essential processes such as redox balance and stress resistance.
Huge congrats to Wendy & colleagues!
shorturl.at/WbFQC
Inorganic sulfate is critical for Mycobacterium tuberculosis lung tissue colonization and redox balance | PNAS
Tuberculosis remains the deadliest infectious disease caused by a single pathogen,
highlighting the urgent need for novel therapies. A deeper under...
www.pnas.org
September 23, 2025 at 3:32 AM
Excited to share Wendy Le Mouëllic’s PhD work, now published in @pnas.org!
It reveals that M. tuberculosis depends on inorganic sulfate import to survive inside host cells—fueling essential processes such as redox balance and stress resistance.
Huge congrats to Wendy & colleagues!
shorturl.at/WbFQC
It reveals that M. tuberculosis depends on inorganic sulfate import to survive inside host cells—fueling essential processes such as redox balance and stress resistance.
Huge congrats to Wendy & colleagues!
shorturl.at/WbFQC
Reposted by Stephen Gordon
New study shows pyrazinamide kills TB by acidifying bacterial cytosol — not via PanD/CoA depletion. A long-standing debate settled, paving the way for smarter PZA-like drugs. #MicroSky
✍️ J. Laudouze, Y. Antonenko, @alexandregouzy.bsky.social, @pierresantucci.bsky.social & coll.
📖 shorturl.at/tuz6Q
✍️ J. Laudouze, Y. Antonenko, @alexandregouzy.bsky.social, @pierresantucci.bsky.social & coll.
📖 shorturl.at/tuz6Q
September 29, 2025 at 4:08 AM
New study shows pyrazinamide kills TB by acidifying bacterial cytosol — not via PanD/CoA depletion. A long-standing debate settled, paving the way for smarter PZA-like drugs. #MicroSky
✍️ J. Laudouze, Y. Antonenko, @alexandregouzy.bsky.social, @pierresantucci.bsky.social & coll.
📖 shorturl.at/tuz6Q
✍️ J. Laudouze, Y. Antonenko, @alexandregouzy.bsky.social, @pierresantucci.bsky.social & coll.
📖 shorturl.at/tuz6Q
Reposted by Stephen Gordon
Delighted to share our latest report in Microbiology Spectrum
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
Assembly of the Mycobacterium tuberculosis type VII ESX-1 secretion system in Mycobacterium smegmatis identifies a new transcriptional activator of esx-1 genes and a novel TB vaccine | Microbiology Sp...
In this study, we modified Mycobacterium smegmatis, which is often used as a surrogate model organism in mycobacterial research, to
produce and assemble a functional Mycobacterium tuberculosis (M. tb)...
journals.asm.org
September 12, 2025 at 8:26 PM
Delighted to share our latest report in Microbiology Spectrum
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
Reposted by Stephen Gordon
Watch @maxgg.bsky.social, Group Leader at the Crick, as he explains what happens to cells that are infected with tuberculosis and how his lab is studying our bodies’ response to this infection.
www.youtube.com/watch?v=VWCt...
www.youtube.com/watch?v=VWCt...
Researching the World’s Deadliest Infectious Disease – with Maximiliano Gutierrez
YouTube video by Francis Crick Institute
www.youtube.com
September 10, 2025 at 3:32 PM
Watch @maxgg.bsky.social, Group Leader at the Crick, as he explains what happens to cells that are infected with tuberculosis and how his lab is studying our bodies’ response to this infection.
www.youtube.com/watch?v=VWCt...
www.youtube.com/watch?v=VWCt...
From Damien Farrell in the lab: 'SNiPgenie: a tool for microbial SNP site detection from whole-genome sequencing data'. doi.org/10.1099/acmi...
September 24, 2025 at 12:22 PM
From Damien Farrell in the lab: 'SNiPgenie: a tool for microbial SNP site detection from whole-genome sequencing data'. doi.org/10.1099/acmi...
The UCD School of Veterinary Medicine is recruiting an Ad Astra Assistant Professor in Antimicrobial Resistance, focusing on immunological research relevant to the development of vaccines, diagnostics and host-directed therapies. More info in link below
www.ucd.ie/vetmed/about...
www.ucd.ie/vetmed/about...
Vacancies - UCD School of Veterinary Medicine
www.ucd.ie
February 15, 2025 at 6:34 PM
The UCD School of Veterinary Medicine is recruiting an Ad Astra Assistant Professor in Antimicrobial Resistance, focusing on immunological research relevant to the development of vaccines, diagnostics and host-directed therapies. More info in link below
www.ucd.ie/vetmed/about...
www.ucd.ie/vetmed/about...
Reposted by Stephen Gordon
Incredibly excited to share that our manuscript was just published in @nature.com ! What a way to start the new year! 🎉
https://buff.ly/4gyYCzx
We present phylowave, a framework that enables to learn the fitness dynamics of pathogens from phylogenies.
🧵 A thread... 1/n
#IDSky #IDModelling
https://buff.ly/4gyYCzx
We present phylowave, a framework that enables to learn the fitness dynamics of pathogens from phylogenies.
🧵 A thread... 1/n
#IDSky #IDModelling
Learning the fitness dynamics of pathogens from phylogenies - Nature
Phylowave, an innovative phylogenetic approach, can identify the main circulating pathogen lineages with increased fitness and the associated genetic changes, enabling the timely identification of…
buff.ly
January 2, 2025 at 8:03 AM
Incredibly excited to share that our manuscript was just published in @nature.com ! What a way to start the new year! 🎉
https://buff.ly/4gyYCzx
We present phylowave, a framework that enables to learn the fitness dynamics of pathogens from phylogenies.
🧵 A thread... 1/n
#IDSky #IDModelling
https://buff.ly/4gyYCzx
We present phylowave, a framework that enables to learn the fitness dynamics of pathogens from phylogenies.
🧵 A thread... 1/n
#IDSky #IDModelling
Reposted by Stephen Gordon
December 24, 2024 at 5:47 PM
Reposted by Stephen Gordon
💥 My 2024 Mile Marker: The inside scoop on how America lost control of the Bird Flu, opening the door for another pandemic.
"We're in a terrible situation" said @angierasmussen.bsky.social
🧵Here's how we got here & how to get out @kffhealthnews.bsky.social kffhealthnews.org/news/article...
"We're in a terrible situation" said @angierasmussen.bsky.social
🧵Here's how we got here & how to get out @kffhealthnews.bsky.social kffhealthnews.org/news/article...
How America Lost Control of the Bird Flu, Setting the Stage for Another Pandemic - KFF Health News
Exclusive reporting reveals how the United States lost track of a virus that could cause the next pandemic. Problems like the sluggish pace of federal action, a deference to industry, and neglect for ...
kffhealthnews.org
December 20, 2024 at 4:12 PM
💥 My 2024 Mile Marker: The inside scoop on how America lost control of the Bird Flu, opening the door for another pandemic.
"We're in a terrible situation" said @angierasmussen.bsky.social
🧵Here's how we got here & how to get out @kffhealthnews.bsky.social kffhealthnews.org/news/article...
"We're in a terrible situation" said @angierasmussen.bsky.social
🧵Here's how we got here & how to get out @kffhealthnews.bsky.social kffhealthnews.org/news/article...
Reposted by Stephen Gordon
Antibody reliability is a massive problem in research and many companies sell antibodies they know do not work. It is one of the main reasons of the reproducibility crisis. www.nature.com/articles/d41...
The antibodies don’t work! The race to rid labs of molecules that ruin experiments
Poorly performing antibodies have plagued biomedical sciences for decades. Several fresh initiatives hope to change this.
www.nature.com
December 14, 2024 at 5:53 PM
Antibody reliability is a massive problem in research and many companies sell antibodies they know do not work. It is one of the main reasons of the reproducibility crisis. www.nature.com/articles/d41...
Reposted by Stephen Gordon
Happy to share our new study now out in Journal of Virology, showing that SARS-CoV-2 entry and fusion are independent of ACE2 localization to lipid rafts. Congrats again to William Bolland, and the @Virus_Immunity team!
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
November 22, 2024 at 8:53 AM
Happy to share our new study now out in Journal of Virology, showing that SARS-CoV-2 entry and fusion are independent of ACE2 localization to lipid rafts. Congrats again to William Bolland, and the @Virus_Immunity team!
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
Reposted by Stephen Gordon
Hope I'm the first to post this all time classic on this platform
November 19, 2024 at 4:51 AM
Hope I'm the first to post this all time classic on this platform
Reposted by Stephen Gordon
Morning frost, Kildare. #photography
November 19, 2024 at 6:32 AM
Morning frost, Kildare. #photography
Reposted by Stephen Gordon
'Gut microbiota clocks in stress'
Nice profile of our recent Cell Metabolism paper in Nature Reviews Microbiology by Agustina Taglialegna
www.nature.com/articles/s41...
Nice profile of our recent Cell Metabolism paper in Nature Reviews Microbiology by Agustina Taglialegna
www.nature.com/articles/s41...
Gut microbiota clocks in stress - Nature Reviews Microbiology
In this study, Tofani et al. demonstrate that the gut microbiota regulates stress responsiveness in mice via the circadian system.
www.nature.com
November 18, 2024 at 10:44 PM
'Gut microbiota clocks in stress'
Nice profile of our recent Cell Metabolism paper in Nature Reviews Microbiology by Agustina Taglialegna
www.nature.com/articles/s41...
Nice profile of our recent Cell Metabolism paper in Nature Reviews Microbiology by Agustina Taglialegna
www.nature.com/articles/s41...
Reposted by Stephen Gordon
The day after winning the prize, the British author discusses choosing to write a story set in space, climate change, and why she didn't set out to write a political novel.
www.newstatesman.com/culture/book...
www.newstatesman.com/culture/book...
Samantha Harvey: “Orbital isn’t the kind of book that normally wins the Booker”
The day after winning the prize, the British author discusses choosing to write a story set in space, climate change, and why she didn't set out to write a political novel.
www.newstatesman.com
November 13, 2024 at 5:57 PM
The day after winning the prize, the British author discusses choosing to write a story set in space, climate change, and why she didn't set out to write a political novel.
www.newstatesman.com/culture/book...
www.newstatesman.com/culture/book...
Reposted by Stephen Gordon
To celebrate the 125th anniversary of the University of Birmingham, we are recruiting 100 Anniversary Fellows and 25 Anniversary Chairs fellowsandchairs.birmingham.ac.uk
If you are interested to join our community of researchers in infection, inflammation and immunology, please DM me!
If you are interested to join our community of researchers in infection, inflammation and immunology, please DM me!
125th Anniversary Fellows and Chairs | University of Birmingham
This is 125 years of NobelPrize-winning research.This is your opportunity to become one of our 125th Anniversary Fellows and Chairs.
fellowsandchairs.birmingham.ac.uk
November 13, 2024 at 8:12 PM
To celebrate the 125th anniversary of the University of Birmingham, we are recruiting 100 Anniversary Fellows and 25 Anniversary Chairs fellowsandchairs.birmingham.ac.uk
If you are interested to join our community of researchers in infection, inflammation and immunology, please DM me!
If you are interested to join our community of researchers in infection, inflammation and immunology, please DM me!
Reposted by Stephen Gordon
Together with Abdallah and Qingtian we just published this pan-genome analysis for M. marinum. I think it is a nice catalog, but standing out for me was the variation in the cpnT gene and the fact that ESX-2 is present in the majority of the M. marinum strains, just not in the type strain M...
Comprehensive pan-genome analysis of Mycobacterium marinum: insights into genomic diversity, evolution, and pathogenicity - Scientific Reports
Scientific Reports - Comprehensive pan-genome analysis of Mycobacterium marinum: insights into genomic diversity, evolution, and pathogenicity
www.nature.com
November 13, 2024 at 12:59 PM
Together with Abdallah and Qingtian we just published this pan-genome analysis for M. marinum. I think it is a nice catalog, but standing out for me was the variation in the cpnT gene and the fact that ESX-2 is present in the majority of the M. marinum strains, just not in the type strain M...
Much of the Emerald Isle Is an Ecological Desert. He’s Trying to Change That. www.nytimes.com/2024/10/18/c...
October 19, 2024 at 9:34 AM
Much of the Emerald Isle Is an Ecological Desert. He’s Trying to Change That. www.nytimes.com/2024/10/18/c...
