Stephane Mouilleron
@stephcrystallab.bsky.social
Reposted by Stephane Mouilleron
This image was made in Blender to show how the protein spectrin fits into the pocket of an enzyme complex known as PP1/Phactr1 while undergoing dephosphorylation.
Dephosphorylation, and the reverse process phosphorylation, are key mechanisms in cell signalling pathways.
Dephosphorylation, and the reverse process phosphorylation, are key mechanisms in cell signalling pathways.
December 5, 2025 at 11:25 AM
This image was made in Blender to show how the protein spectrin fits into the pocket of an enzyme complex known as PP1/Phactr1 while undergoing dephosphorylation.
Dephosphorylation, and the reverse process phosphorylation, are key mechanisms in cell signalling pathways.
Dephosphorylation, and the reverse process phosphorylation, are key mechanisms in cell signalling pathways.
Reposted by Stephane Mouilleron
Postdoc positions open in my lab (Francis Crick Institute) to study
1. initiation of DNA replication.
2. chromatin replication/epigenetic inheritance.
Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists.
Deadline 3 August 2025.
crick.wd3.myworkdayjobs.com/External/job...
1. initiation of DNA replication.
2. chromatin replication/epigenetic inheritance.
Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists.
Deadline 3 August 2025.
crick.wd3.myworkdayjobs.com/External/job...
June 20, 2025 at 9:38 AM
Postdoc positions open in my lab (Francis Crick Institute) to study
1. initiation of DNA replication.
2. chromatin replication/epigenetic inheritance.
Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists.
Deadline 3 August 2025.
crick.wd3.myworkdayjobs.com/External/job...
1. initiation of DNA replication.
2. chromatin replication/epigenetic inheritance.
Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists.
Deadline 3 August 2025.
crick.wd3.myworkdayjobs.com/External/job...
Reposted by Stephane Mouilleron
We're hiring a postdoc!
Applications from any nationality welcome.
Projects around protein folding in cells, ribosomes, chaperones etc.
4 yr contract, fantastic research environment @crick.ac.uk
crick.wd3.myworkdayjobs.com/External/job...
Applications from any nationality welcome.
Projects around protein folding in cells, ribosomes, chaperones etc.
4 yr contract, fantastic research environment @crick.ac.uk
crick.wd3.myworkdayjobs.com/External/job...
Postdoctoral Fellow - Balchin Lab
Salary for this Role: From £43,210 with benefits, subject to skills and experience Job Title: Postdoctoral Fellow - Balchin Lab Reports to: David Balchin Closing Date: 28/Feb/2025 23.59 GMT Job Descri...
crick.wd3.myworkdayjobs.com
January 20, 2025 at 5:45 PM
We're hiring a postdoc!
Applications from any nationality welcome.
Projects around protein folding in cells, ribosomes, chaperones etc.
4 yr contract, fantastic research environment @crick.ac.uk
crick.wd3.myworkdayjobs.com/External/job...
Applications from any nationality welcome.
Projects around protein folding in cells, ribosomes, chaperones etc.
4 yr contract, fantastic research environment @crick.ac.uk
crick.wd3.myworkdayjobs.com/External/job...
December 28, 2024 at 9:10 AM
True !
I also noticed this, no more spaghettis around a globular domain (AF2) but predicted helices with very bad plddt score (AF3).
This is very confusing for someone who doesn't pay much attention to pLddT scoring!
I also noticed this, no more spaghettis around a globular domain (AF2) but predicted helices with very bad plddt score (AF3).
This is very confusing for someone who doesn't pay much attention to pLddT scoring!
AlphaFold3 still tends to overfit regions that AF2 multimer predicts to be disordered. Almost all disordered regions become helices in AF3.
December 16, 2024 at 7:26 AM
True !
I also noticed this, no more spaghettis around a globular domain (AF2) but predicted helices with very bad plddt score (AF3).
This is very confusing for someone who doesn't pay much attention to pLddT scoring!
I also noticed this, no more spaghettis around a globular domain (AF2) but predicted helices with very bad plddt score (AF3).
This is very confusing for someone who doesn't pay much attention to pLddT scoring!
I really enjoyed the AsCA 2024 meeting in Kuala Lumpur! A lot of great sciences and great people in a great city! @crick.ac.uk
December 14, 2024 at 5:56 PM
I really enjoyed the AsCA 2024 meeting in Kuala Lumpur! A lot of great sciences and great people in a great city! @crick.ac.uk
December 14, 2024 at 4:39 PM
December 14, 2024 at 4:32 PM
December 14, 2024 at 4:31 PM
December 14, 2024 at 4:17 PM
Reposted by Stephane Mouilleron
I couldn't find one so I made one. Scientists who blend starter pack! Follow all the coolest #b3d science renders! I don't know everyone (or really anyone) so self-nominate and I'll add you in! (Bonus points if you post a cool render) go.bsky.app/S253qJN
November 23, 2024 at 7:55 PM
I couldn't find one so I made one. Scientists who blend starter pack! Follow all the coolest #b3d science renders! I don't know everyone (or really anyone) so self-nominate and I'll add you in! (Bonus points if you post a cool render) go.bsky.app/S253qJN